{"id":352,"date":"2026-08-21T09:00:00","date_gmt":"2026-08-21T09:00:00","guid":{"rendered":"https:\/\/all-cancers.com\/cancer\/diffuse-intrinsic-pontine-glioma-dipg-cancer-types\/"},"modified":"2026-10-29T13:38:05","modified_gmt":"2026-10-29T13:38:05","slug":"diffuse-intrinsic-pontine-glioma-dipg-cancer-types","status":"publish","type":"cancer_type","link":"https:\/\/all-cancers.com\/zh-hk\/cancer\/diffuse-intrinsic-pontine-glioma-dipg-cancer-types\/","title":{"rendered":"\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG)"},"content":{"rendered":"<div class=\"ac-blog-article\">\n<p class=\"ac-blog-lead\"><strong>\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG) \u662f\u4e00\u7a2e\u9ad8\u5ea6\u4fb5\u8972\u6027\u7684\u60e1\u6027\u8166\u5e79\u816b\u7624\uff0c\u4e3b\u8981\u5f71\u97ff 5-10 \u6b72\u7684\u5152\u7ae5\u3002 DIPG \u8d77\u6e90\u65bc\u8166\u5e79\u7684\u8166\u6a4b\u5340\u57df\uff0c\u76f4\u63a5\u5f71\u97ff\u547c\u5438\u3001\u5fc3\u7387\u8abf\u7bc0\u548c\u904b\u52d5\u5354\u8abf\u7b49\u57fa\u672c\u529f\u80fd\uff0c\u70ba\u60a3\u8005\u548c\u5bb6\u4eba\u5e36\u4f86\u91cd\u5927\u7684\u6cbb\u7642\u6311\u6230\u548c\u6bc0\u6ec5\u6027\u7684\u60c5\u7dd2\u5f71\u97ff\u3002<\/strong><\/p>\n<nav class=\"ac-blog-toc\" aria-label=\"\u672c\u6587\u5c0e\u89bd\">\n<p><strong>\u672c\u6587\u5c0e\u89bd<\/strong><\/p>\n<ul>\n<li><a href=\"#what-is-diffuse-intrinsic-pontine-glioma-dipg\">\u4ec0\u9ebc\u662f\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG)\uff1f<\/a><\/li>\n<li><a href=\"#causes-and-risk-factors-of-diffuse-intrinsic-pontine-glioma-dipg\">\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG) \u7684\u75c5\u56e0\u548c\u5371\u96aa\u56e0\u5b50<\/a><\/li>\n<li><a href=\"#symptoms-of-diffuse-intrinsic-pontine-glioma-dipg\">\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG) \u7684\u75c7\u72c0<\/a><\/li>\n<li><a href=\"#stages-of-diffuse-intrinsic-pontine-glioma-dipg-and-survival-rates\">\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG) \u7684\u968e\u6bb5\u548c\u5b58\u6d3b\u7387<\/a><\/li>\n<li><a href=\"#limitations-of-traditional-therapies-for-diffuse-intrinsic-pontine-glioma-dipg\">\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG) \u50b3\u7d71\u7642\u6cd5\u7684\u5c40\u9650\u6027<\/a><\/li>\n<\/ul>\n<\/nav>\n<h2 id=\"what-is-diffuse-intrinsic-pontine-glioma-dipg\">\u4ec0\u9ebc\u662f <strong>\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG)<\/strong>?<\/h2>\n<p>\u5f9e\u751f\u7269\u5b78\u89d2\u5ea6\u4f86\u770b\uff0cDIPG \u816b\u7624\u7684\u7279\u5fb5\u662f\u795e\u7d93\u81a0\u8cea\u7624\u7d30\u80de\u9ad8\u5ea6\u6d78\u6f64\uff0c\u5e7e\u4e4e\u4e0d\u53ef\u80fd\u900f\u904e\u624b\u8853\u5b8c\u5168\u5207\u9664\u3002 DIPG \u7684\u907a\u50b3\u6a19\u8a8c\u901a\u5e38\u6d89\u53ca\u5728\u5168\u7403 80% \u4ee5\u4e0a\u7684 DIPG \u75c5\u4f8b\u4e2d\u89c0\u5bdf\u5230\u7684\u7d44\u86cb\u767d H3 K27M \u7b49\u7a81\u8b8a\u3002\u9019\u4e9b\u57fa\u56e0\u6539\u8b8a\u6975\u5927\u5730\u5f71\u97ff\u57fa\u56e0\u8868\u9054\uff0c\u63a8\u52d5\u816b\u7624\u5feb\u901f\u751f\u9577\u3002<\/p>\n<p>DIPG \u7d30\u80de\u7684\u4e00\u500b\u503c\u5f97\u6ce8\u610f\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\u8207 Warburg \u6548\u61c9\u76f4\u63a5\u76f8\u95dc\uff0c\u5373\u764c\u7d30\u80de\u6d88\u8017\u8461\u8404\u7cd6\u7684\u901f\u5ea6\u6bd4\u6b63\u5e38\u7d30\u80de\u5feb 200 \u500d\u3002 DIPG \u7d30\u80de\u4e0d\u662f\u6709\u6548\u5229\u7528\u6c27\u6c23\u4f86\u7522\u751f ATP\uff0c\u800c\u662f\u4e3b\u8981\u900f\u904e\u7121\u6c27\u7cd6\u89e3\u4f5c\u7528\u7372\u53d6\u80fd\u91cf\uff0c\u7522\u751f\u904e\u91cf\u7684\u4e73\u9178\u4e26\u5275\u9020\u9178\u6027\u816b\u7624\u5fae\u74b0\u5883\uff0c\u5f9e\u800c\u589e\u5f37\u4fb5\u8972\u6027\u3002<\/p>\n<p>\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0c\u6bcf\u5e74\u7d04\u6709 300-400 \u4f8b\u5152\u7ae5\u65b0\u767c DIPG \u75c5\u4f8b\uff0c\u7d04\u4f54\u5168\u7403\u5152\u7ae5\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u816b\u7624\u7684 10-15%\u3002\u5728\u9999\u6e2f\uff0cDIPG \u75c5\u4f8b\u6578\u91cf\u53cd\u6620\u4e86\u5168\u7403\u6a21\u5f0f\uff0c\u7d66\u5bb6\u5ead\u548c\u91ab\u7642\u4fdd\u5065\u63d0\u4f9b\u8005\u5e36\u4f86\u4e86\u5de8\u5927\u7684\u60c5\u611f\u548c\u8eab\u9ad4\u8ca0\u64d4\u3002\u7576\u7236\u6bcd\u56e0\u6b77\u53f2\u4e0a\u6709\u9650\u7684\u6cbb\u7642\u9032\u5c55\u800c\u6536\u5230\u4ee4\u4eba\u75db\u82e6\u7684\u9810\u5f8c\u6642\uff0c\u9019\u7a2e\u60c5\u6cc1\u5c24\u5176\u8907\u96dc\u3002<\/p>\n<p>\u5728\u60c5\u7dd2\u4e0a\uff0cDIPG \u8a3a\u65b7\u6703\u986f\u8457\u5f71\u97ff\u5bb6\u5ead\u52d5\u614b\uff0c\u5e38\u5e38\u5c0e\u81f4\u9577\u671f\u7684\u5fc3\u7406\u56f0\u64fe\u3001\u7126\u616e\u3001\u6182\u9b31\u548c\u7d93\u6fdf\u56f0\u96e3\u3002\u5728\u8eab\u9ad4\u4e0a\uff0c\u5e74\u8f15\u60a3\u8005\u6703\u56e0\u816b\u7624\u4f4d\u7f6e\u800c\u51fa\u73fe\u8870\u5f31\u75c7\u72c0\uff1a<\/p>\n<ul>\n<li>\u541e\u56a5\u548c\u8aaa\u8a71\u56f0\u96e3\uff08\u541e\u56a5\u56f0\u96e3\u3001\u69cb\u97f3\u969c\u7919\uff09<\/li>\n<li>\u5e73\u8861\u548c\u5354\u8abf\u554f\u984c\uff08\u5171\u6fdf\u5931\u8abf\uff09<\/li>\n<li>\u81c9\u90e8\u808c\u8089\u7121\u529b\u548c\u9ebb\u75fa<\/li>\n<li>\u9871\u5167\u58d3\u589e\u9ad8\u5c0e\u81f4\u5287\u70c8\u982d\u75db<\/li>\n<\/ul>\n<p>\u9451\u65bc DIPG \u7684\u56b4\u91cd\u6027\u548c\u5177\u6709\u6311\u6230\u6027\u7684\u9810\u5f8c\uff0c\u5fb9\u5e95\u4e86\u89e3\u9019\u7a2e\u75be\u75c5\u53ef\u4ee5\u4fc3\u9032\u65e9\u671f\u767c\u73fe\uff0c\u4e26\u70ba\u6539\u5584\u7d50\u679c\u5e36\u4f86\u91cd\u8981\u5e0c\u671b\u3002\u5728 AllCancer\uff0c\u6211\u5011\u9769\u547d\u6027\u7684 HK \u4ee3\u8b1d\u7642\u6cd5\u63d0\u4f9b\u4e86\u65b0\u7684\u5e0c\u671b\u71c8\u5854\uff0c\u91dd\u5c0d\u764c\u75c7\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u5982\u7570\u5e38\u7684\u8461\u8404\u7cd6\u651d\u53d6\u548c\u9ea9\u91af\u80fa\u9178\u4f9d\u8cf4\u3002<\/p>\n<p>\u900f\u904e\u4ee3\u8b1d\u9776\u5411\uff0c\u6211\u5011\u7684\u76ee\u6a19\u662f\u5c07\u4fb5\u8972\u6027\u816b\u7624\u8f49\u5316\u70ba\u53ef\u63a7\u7684\u6162\u6027\u75be\u75c5\uff0c\u9019\u8207\u6211\u5011\u5c07\u764c\u75c7\u4f5c\u70ba\u4e00\u7a2e\u6162\u6027\u75be\u75c5\u9032\u884c\u7ba1\u7406\u7684\u5275\u65b0 2025 \u5e74\u76ee\u6a19\u76f8\u4e00\u81f4\uff0c\u5c07\u6cbb\u7642\u65b9\u6cd5\u8f49\u5411\u66f4\u5149\u660e\u3001\u5145\u6eff\u5e0c\u671b\u7684\u672a\u4f86\u2014\u2014<a href=\"\/zh-hk\/treatment-cancer\/\">\u5728\u6b64\u8655\u8a73\u7d30\u4e86\u89e3\u6211\u5011\u9769\u547d\u6027\u7684\u4ee3\u8b1d\u816b\u7624\u5b78\u65b9\u6cd5\u3002<\/a><\/p>\n<h3 id=\"understanding-diffuse-intrinsic-pontine-glioma-dipg-metabolic-vulnerabilities\">\u4e86\u89e3\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG) \u4ee3\u8b1d\u8106\u5f31\u6027<\/h3>\n<p>\u764c\u7d30\u80de\u56b4\u91cd\u4f9d\u8cf4\u8461\u8404\u7cd6\u4ee3\u8b1d\uff08\u74e6\u723e\u5821\u6548\u61c9\uff09\uff0c\u9019\u4f7f\u5f97\u5b83\u5011\u5c0d\u4ee3\u8b1d\u7642\u6cd5\u7279\u5225\u654f\u611f\u3002\u5177\u9ad4\u4f86\u8aaa\uff0cDIPG \u4ee3\u8b1d\u8b5c\u986f\u793a\u8461\u8404\u7cd6\u651d\u53d6\u548c\u7121\u6c27\u7cd6\u9175\u89e3\u7684\u80fd\u529b\u589e\u5f37\uff0c\u5f37\u8abf\u4e86\u4ee3\u8b1d\u5e79\u9810\u7b56\u7565\u7684\u6f5b\u5728\u6cbb\u7642\u76ee\u6a19\u3002<\/p>\n<p>AllCancer \u6700\u8fd1\u7684\u5275\u65b0\u5229\u7528\u4e86\u9019\u4e9b\u4ee3\u8b1d\u9014\u5f91\uff0c\u7d50\u5408\u4e86\u674e\u570b\u83ef\u535a\u58eb\u548c\u5289\u570b\u9f8d\u6559\u6388\u7b49\u8457\u540d\u79d1\u5b78\u5bb6\u7372\u5f97\u8afe\u8c9d\u723e\u734e\u652f\u6301\u7684\u767c\u73fe\u3002\u9019\u9805\u79d1\u5b78\u57fa\u790e\u78ba\u4fdd\u6bcf\u9805\u6cbb\u7642\u5747\u7b26\u5408\u56b4\u683c\u7684\u570b\u969b\u6a19\u6e96\uff0c\u7cbe\u78ba\u91dd\u5c0d\u4ee3\u8b1d\u4f9d\u8cf4\u6027\uff0c\u9032\u800c\u5927\u5e45\u63d0\u5347\u6cbb\u7642\u6548\u679c\u3002<\/p>\n<h2 id=\"causes-and-risk-factors-of-diffuse-intrinsic-pontine-glioma-dipg\">\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG) \u7684\u75c5\u56e0\u548c\u5371\u96aa\u56e0\u5b50<\/h2>\n<p>\u4e86\u89e3\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG) \u7684\u78ba\u5207\u539f\u56e0\u4ecd\u7136\u5f88\u8907\u96dc\uff0c\u6d89\u53ca\u8a31\u591a\u907a\u50b3\u548c\u74b0\u5883\u56e0\u7d20\u3002\u96d6\u7136 DIPG \u75c5\u4f8b\u986f\u793a\u51fa\u660e\u986f\u7684\u57fa\u56e0\u7a81\u8b8a\u6a21\u5f0f\uff0c\u4f46\u5c1a\u672a\u78ba\u5b9a\u8207\u751f\u6d3b\u65b9\u5f0f\u76f8\u95dc\u7684\u660e\u78ba\u56e0\u7d20\u4e4b\u9593\u7684\u806f\u7e6b\uff0c\u9019\u5f37\u8abf\u4e86\u57fa\u56e0\u7814\u7a76\u5728 DIPG \u56e0\u679c\u95dc\u4fc2\u548c\u5371\u96aa\u56e0\u7d20\u4e2d\u7684\u91cd\u8981\u6027\u3002<\/p>\n<h3 id=\"genetic-factors-influencing-dipg-development\">\u5f71\u97ff DIPG \u767c\u80b2\u7684\u907a\u50b3\u56e0\u7d20<\/h3>\n<p>\u5927\u7d04 80% \u7684 DIPG \u816b\u7624\u5b58\u5728\u6d89\u53ca\u7d44\u86cb\u767d H3 K27M \u7684\u7279\u5b9a\u7a81\u8b8a\uff0c\u9019\u662f\u8207\u816b\u7624\u9032\u5c55\u5bc6\u5207\u76f8\u95dc\u7684\u95dc\u9375\u57fa\u56e0\u6539\u8b8a\u3002\u5df2\u78ba\u5b9a\u7684\u5176\u4ed6\u57fa\u56e0\u7a81\u8b8a\u5305\u62ec TP53 \u548c PDGFRA \u64f4\u589e\uff0c\u5b83\u5011\u6703\u52a0\u901f\u816b\u7624\u751f\u9577\u4e26\u964d\u4f4e\u5c0d\u5e38\u898f\u7642\u6cd5\u7684\u53cd\u61c9\u3002<\/p>\n<ul>\n<li><strong>\u7d44\u86cb\u767d H3 K27M \u7a81\u8b8a\uff1a<\/strong> \u986f\u8457\u6539\u8b8a\u57fa\u56e0\u8f49\u9304\uff0c\u4fc3\u9032\u7d30\u80de\u589e\u751f\u3002<\/li>\n<li><strong>TP53\u7a81\u8b8a\uff1a<\/strong> \u5e38\u898b\u7684\u816b\u7624\u6291\u5236\u57fa\u56e0\u6539\u8b8a\u963b\u7919\u4e86\u81ea\u7136\u7d30\u80de\u6b7b\u4ea1\u6a5f\u5236\u3002<\/li>\n<li><strong>PDGFRA \u64f4\u589e\uff1a<\/strong> \u6709\u52a9\u65bc\u589e\u52a0\u764c\u7d30\u80de\u5206\u88c2\u548c\u816b\u7624\u8840\u7ba1\u5316\u3002<\/li>\n<\/ul>\n<p>\u53ca\u65e9\u8b58\u5225\u9019\u4e9b\u907a\u50b3\u56e0\u7d20\u53ef\u4ee5\u70ba\u53ca\u6642\u7684\u6cbb\u7642\u4ecb\u5165\u3001\u6539\u5584\u81e8\u5e8a\u7ba1\u7406\u548c\u6539\u5584\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u63d0\u4f9b\u91cd\u8981\u8cc7\u8a0a\u3002\u56e0\u6b64\uff0c\u57fa\u56e0\u5206\u6790\u69cb\u6210\u4e86 AllCancer DIPG \u8a3a\u65b7\u548c\u6cbb\u7642\u65b9\u6cd5\u7684\u91cd\u8981\u7d44\u6210\u90e8\u5206\u3002<\/p>\n<h3 id=\"environmental-and-regional-risk-factors\">\u74b0\u5883\u548c\u5340\u57df\u98a8\u96aa\u56e0\u7d20<\/h3>\n<p>\u8207\u8207\u74b0\u5883\u6216\u751f\u6d3b\u65b9\u5f0f\u98a8\u96aa\u56e0\u7d20\u5bc6\u5207\u76f8\u95dc\u7684\u764c\u75c7\uff08\u4f8b\u5982\uff0c\u5438\u7159\u5c0e\u81f4\u80ba\u764c\u6216\u7d2b\u5916\u7dda\u7167\u5c04\u5c0e\u81f4\u76ae\u819a\u764c\uff09\u4e0d\u540c\uff0cDIPG \u5c1a\u672a\u8b49\u660e\u8207\u74b0\u5883\u6709\u5f88\u5f37\u7684\u76f8\u95dc\u6027\u3002\u5118\u7ba1\u5982\u6b64\uff0c\u9999\u6e2f\u548c\u4e9e\u6d32\u7684\u6d41\u884c\u75c5\u5b78\u7814\u7a76\u4ecd\u5728\u4e0d\u65b7\u8abf\u67e5\u53ef\u80fd\u5f71\u97ff DIPG \u76db\u884c\u7387\u6216\u56b4\u91cd\u7a0b\u5ea6\u7684\u6f5b\u5728\u5340\u57df\u98a8\u96aa\u6a21\u5f0f\u6216\u50be\u5411\u3002<\/p>\n<p>\u8207MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u548c\u6df1\u5733\u524d\u6d77\u6cf0\u5eb7\u7b49\u9818\u5148\u7684\u570b\u969b\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u5408\u4f5c\u7684\u7814\u7a76\u8a08\u5283\u7e7c\u7e8c\u7814\u7a76\u6f5b\u5728\u7684\u76f8\u95dc\u6027\uff0c\u78ba\u4fdd\u5c0d\u4e9e\u6d32\u4eba\u7fa4\u4e2d\u7684DIPG\u6d41\u884c\u75c5\u5b78\u6709\u57fa\u65bc\u8b49\u64da\u7684\u4e86\u89e3\u3002<\/p>\n<h3 id=\"metabolic-vulnerabilities-glucose-and-glutamine-dependency\">\u4ee3\u8b1d\u8106\u5f31\u6027\uff1a\u8461\u8404\u7cd6\u548c\u9ea9\u91af\u80fa\u9178\u4f9d\u8cf4\u6027<\/h3>\n<p>DIPG \u548c\u76f8\u95dc\u764c\u75c7\u7684\u4e00\u500b\u7368\u7279\u7279\u5fb5\u662f\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u5c24\u5176\u662f\u8461\u8404\u7cd6\u548c\u9ea9\u91af\u80fa\u9178\u6210\u766e\u3002 DIPG \u7d30\u80de\u5927\u91cf\u5229\u7528\u6709\u6c27\u7cd6\u89e3\u4f5c\u7528\uff08Warburg \u6548\u61c9\uff09\uff0c\u986f\u8457\u4f9d\u8cf4\u8461\u8404\u7cd6\u651d\u53d6\u7684\u589e\u52a0\uff0c\u8868\u73fe\u70ba\u986f\u8457\u7684\u6cbb\u7642\u654f\u611f\u5ea6\uff1a<\/p>\n<ul>\n<li>\u5728 DIPG \u7d30\u80de\u4e2d\u89c0\u5bdf\u5230\u9ad8\u8461\u8404\u7cd6\u4f9d\u8cf4\u6027\u4ee5\u5be6\u73fe\u5feb\u901f\u589e\u6b96\u548c\u751f\u9577\u3002<\/li>\n<li>\u9ea9\u91af\u80fa\u9178\u4f9d\u8cf4\u6027\u652f\u6301\u5c0d DIPG \u816b\u7624\u751f\u5b58\u81f3\u95dc\u91cd\u8981\u7684\u6838\u82f7\u9178\u548c\u86cb\u767d\u8cea\u5408\u6210\u9014\u5f91\u3002<\/li>\n<li>\u4ee3\u8b1d\u6a19\u9776\u6cbb\u7642\u5728\u6700\u8fd1\u7684\u7814\u7a76\u548c\u65e9\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u986f\u793a\u51fa\u4e86\u5e0c\u671b\uff0c\u7279\u5225\u662f\u7576\u6574\u5408\u5230\u7d9c\u5408\u4ee3\u8b1d\u7642\u6cd5\u4e2d\u6642\uff0c\u4f8b\u5982 AllCancer \u7684 HK \u4ee3\u8b1d\u7642\u6cd5\u3002<\/li>\n<\/ul>\n<p>\u8a8d\u8b58\u5230\u9019\u4e9b\u8106\u5f31\u6027\uff0c\u53ef\u4ee5\u88fd\u5b9a\u660e\u78ba\u8a2d\u8a08\u7684\u5c16\u7aef\u6cbb\u7642\u7b56\u7565\uff0c\u4ee5\u62c6\u9664 DIPG \u7684\u4ee3\u8b1d\u652f\u6301\u7cfb\u7d71\uff0c\u6700\u7d42\u6539\u8b8a\u50b3\u7d71\u7684\u6cbb\u7642\u6a21\u5f0f\u3002 AllCancer \u7e7c\u7e8c\u5229\u7528\u4ee3\u8b1d\u9014\u5f91\uff0c\u5c0b\u6c42\u5be6\u73fe\u5176\u96c4\u5fc3\u52c3\u52c3\u7684\u76ee\u6a19\uff0c\u5373\u5728 2025 \u5e74\u5c07 DIPG \u6cbb\u7642\u5f9e\u6025\u6027\u75be\u75c5\u7ba1\u7406\u8f49\u8b8a\u70ba\u6162\u6027\u75be\u75c5\u7ba1\u7406\u3002<\/p>\n<h2 id=\"symptoms-of-diffuse-intrinsic-pontine-glioma-dipg\">\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG) \u7684\u75c7\u72c0<\/h2>\n<p>\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG) \u662f\u4e00\u7a2e\u7f55\u898b\u7684\u4fb5\u8972\u6027\u8166\u5e79\u816b\u7624\uff0c\u4e3b\u8981\u5f71\u97ff\u5152\u7ae5\uff0c\u901a\u5e38\u5e74\u9f61\u5728 5 \u81f3 9 \u6b72\u4e4b\u9593\u3002\u53ca\u65e9\u8b58\u5225\u75c7\u72c0\u4e26\u53ca\u6642\u5c0b\u6c42\u91ab\u7642\u8a55\u4f30\u5c0d\u65bc\u7372\u5f97\u66f4\u597d\u7684\u81e8\u5e8a\u7d50\u679c\u81f3\u95dc\u91cd\u8981\u3002<\/p>\n<h3 id=\"common-symptoms-of-dipg-include\">DIPG \u7684\u5e38\u898b\u75c7\u72c0\u5305\u62ec\uff1a<\/h3>\n<ul>\n<li>\u773c\u7403\u904b\u52d5\u56f0\u96e3\uff08\u773c\u808c\u9ebb\u75fa\uff09<\/li>\n<li>\u8907\u8996\uff08\u8907\u8996\uff09<\/li>\n<li>\u81c9\u90e8\u7121\u529b\u6216\u7671\u7613<\/li>\n<li>\u5480\u56bc\u3001\u541e\u56a5\u6216\u8aaa\u8a71\u554f\u984c\uff08\u69cb\u97f3\u969c\u7919\uff09<\/li>\n<li>\u4e0d\u5e73\u8861\u548c\u5354\u8abf\u554f\u984c\uff08\u5171\u6fdf\u5931\u8abf\uff09<\/li>\n<li>\u982d\u75db\uff0c\u5c24\u5176\u662f\u7531\u65bc\u9871\u5167\u58d3\u589e\u9ad8\u800c\u5c0e\u81f4\u7684\u65e9\u6668\u982d\u75db<\/li>\n<li>\u7121\u660e\u78ba\u80c3\u8178\u9053\u539f\u56e0\u7684\u5641\u5fc3\u548c\u5614\u5410<\/li>\n<li>\u6d41\u53e3\u6c34\u6216\u96e3\u4ee5\u63a7\u5236\u553e\u6db2<\/li>\n<li>\u5168\u8eab\u75b2\u52de\u548c\u4e0d\u660e\u539f\u56e0\u7684\u7169\u8e81<\/li>\n<\/ul>\n<p>\u9019\u4e9b\u75c7\u72c0\u4e3b\u8981\u53cd\u6620\u816b\u7624\u751f\u7269\u5b78\u548c\u4f4d\u7f6e\u3002\u7531\u65bc DIPG \u51fa\u73fe\u5728\u8166\u5e79\u7684\u8166\u6a4b\u5340\u57df\uff08\u63a7\u5236\u91cd\u8981\u529f\u80fd\u7684\u95dc\u9375\u4e2d\u7e7c\u4e2d\u5fc3\uff09\uff0c\u56e0\u6b64\u5b83\u5011\u76f4\u63a5\u5f71\u97ff\u904b\u52d5\u3001\u611f\u89ba\u77e5\u89ba\u548c\u8166\u795e\u7d93\u529f\u80fd\u3002<\/p>\n<p>\u65e9\u671f\u767c\u73fe\u5927\u5927\u63d0\u9ad8\u4e86\u6cbb\u7642\u7684\u53ef\u80fd\u6027\u3002\u56e0\u6b64\uff0c\u4efb\u4f55\u51fa\u73fe\u9019\u4e9b\u75c7\u72c0\u7684\u5152\u7ae5\uff0c\u7279\u5225\u662f\u5982\u679c\u75c7\u72c0\u8fc5\u901f\u60e1\u5316\uff0c\u61c9\u7acb\u5373\u5c0b\u6c42\u5c08\u9580\u5f9e\u4e8b\u5152\u79d1\u816b\u7624\u5b78\u548c\u795e\u7d93\u75c5\u5b78\u7684\u91ab\u7642\u4fdd\u5065\u63d0\u4f9b\u8005\u7684\u8a55\u4f30\u3002<\/p>\n<p>\u767c\u73fe\u65e9\u671f\u8a3a\u65b7\u6280\u8853\uff1a <a href=\"\/zh-hk\/our-hospital\/\">\u7acb\u5373\u63a2\u7d22 DIPG \u8a3a\u65b7\u6e2c\u8a66<\/a><\/p>\n<h2 id=\"stages-of-diffuse-intrinsic-pontine-glioma-dipg-and-survival-rates\">\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG) \u7684\u968e\u6bb5\u548c\u5b58\u6d3b\u7387<\/h2>\n<p>\u7531\u65bc\u816b\u7624\u7684\u4fb5\u8972\u6027\u751f\u9577\u6a21\u5f0f\u53ca\u5176\u95dc\u9375\u7684\u89e3\u5256\u4f4d\u7f6e\uff0cDIPG \u7684\u5206\u671f\u8207\u5176\u4ed6\u764c\u75c7\u986f\u8457\u4e0d\u540c\u3002\u901a\u5e38\u6839\u64da\u81e8\u5e8a\u548c\u653e\u5c04\u5b78\u7d50\u679c\u9032\u884c\u5206\u985e\uff0c\u4e86\u89e3 DIPG \u9032\u5c55\u968e\u6bb5\u6709\u52a9\u65bc\u505a\u51fa\u660e\u667a\u7684\u6cbb\u7642\u6c7a\u7b56\u4e26\u652f\u6301\u6e96\u78ba\u7684\u9810\u5f8c\u3002<\/p>\n<h3 id=\"stage-1-early-diffuse-intrinsic-pontine-glioma-dipg\">\u7b2c\u4e00\u968e\u6bb5 \u2013 \u65e9\u671f\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG)<\/h3>\n<p>\u65e9\u671f DIPG \u7684\u4e00\u822c\u7279\u5fb5\u662f\u5c40\u9650\u65bc\u8166\u6a4b\u5167\u7684\u5c40\u90e8\u7570\u5e38\u7d30\u80de\u751f\u9577\uff0c\u901a\u5e38\u900f\u904e MRI \u5f71\u50cf\u6aa2\u6e2c\u5230\u3002\u5728\u9019\u500b\u65e9\u671f\u968e\u6bb5\uff0c\u51fa\u73fe\u7684\u75c7\u72c0\u53ef\u80fd\u662f\u8f15\u5fae\u7684\u3001\u5fae\u5999\u7684\uff0c\u5f88\u5bb9\u6613\u88ab\u8aa4\u8a8d\u70ba\u662f\u5176\u4ed6\u4e0d\u592a\u56b4\u91cd\u7684\u60c5\u6cc1\u3002<\/p>\n<ul>\n<li><strong>\u816b\u7624\u5927\u5c0f\uff1a<\/strong> \u6210\u50cf\u6383\u63cf\u6642\u901a\u5e38\u5c0f\u65bc 2 \u516c\u5206\u3002<\/li>\n<li><strong>\u75c7\u72c0\uff1a<\/strong> \u8f15\u5ea6\u982d\u75db\u3001\u8f15\u5fae\u8996\u529b\u969c\u7919\u3001\u8f15\u5fae\u81c9\u90e8\u4e0d\u5c0d\u7a31\u3002<\/li>\n<li><strong>\u6cbb\u7642\u65b9\u6848\uff1a<\/strong> \u521d\u6b65\u8a55\u4f30\u901a\u5e38\u6d89\u53ca\u653e\u5c04\u6cbb\u7642\u3001\u91dd\u5c0d DIPG \u5c0d\u8461\u8404\u7cd6\u4ee3\u8b1d\uff08\u74e6\u723e\u5821\u6548\u61c9\uff09\u7684\u4f9d\u8cf4\u7684\u6f5b\u5728\u65b0\u8208\u4ee3\u8b1d\u5e79\u9810\u7642\u6cd5\u4ee5\u53ca\u7814\u7a76\u6027\u81e8\u5e8a\u8a66\u9a57\u3002<\/li>\n<li><strong>\u5b58\u6d3b\u7387\uff1a<\/strong> \u65e9\u671f\u8a3a\u65b7\u548c\u958b\u59cb\u6cbb\u7642\u53ef\u4ee5\u9069\u5ea6\u6539\u5584\u9810\u5f8c\u3002\u50b3\u7d71\u4e0a\uff0c\u4e2d\u4f4d\u5b58\u6d3b\u671f\u70ba 9-12 \u500b\u6708\uff0c\u4f46\u65b0\u7642\u6cd5\u6709\u671b\u6539\u5584\u7d50\u679c\u3002<\/li>\n<\/ul>\n<h3 id=\"stage-2-progressed-diffuse-intrinsic-pontine-glioma-dipg\">\u7b2c 2 \u671f \u2013 \u9032\u5c55\u6027\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG)<\/h3>\n<p>\u96a8\u8457 DIPG \u7684\u9032\u5c55\uff0c\u816b\u7624\u7d30\u80de\u6d78\u6f64\u66f4\u6df1\u7684\u8166\u5e79\u7d50\u69cb\u6216\u5c3a\u5bf8\u7565\u6709\u64f4\u5927\u3002\u5728\u6b64\u4e2d\u9593\u968e\u6bb5\uff0c\u75c7\u72c0\u5f37\u5ea6\u901a\u5e38\u6703\u589e\u52a0\uff0c\u5f15\u8d77\u81e8\u5e8a\u91ab\u751f\u548c\u8b77\u7406\u4eba\u54e1\u7684\u6ce8\u610f\u3002<\/p>\n<ul>\n<li><strong>\u816b\u7624\u7279\u5fb5\uff1a<\/strong> \u589e\u91cf\u751f\u9577&gt;2\u5398\u7c73\uff0c\u8166\u6a4b\u5167\u8f15\u5fae\u64f4\u6563\u3002<\/li>\n<li><strong>\u75c7\u72c0\uff1a<\/strong> \u660e\u986f\u7684\u5354\u8abf\u56f0\u96e3\u3001\u982d\u75db\u52a0\u5287\u3001\u983b\u7e41\u5614\u5410\u3001\u660e\u986f\u7684\u9871\u795e\u7d93\u53d7\u7d2f\uff08\u4f8b\u5982\u81c9\u90e8\u4e0b\u5782\u3001\u541e\u56a5\u56f0\u96e3\uff09\u3002<\/li>\n<li><strong>\u6cbb\u7642\u5347\u7d1a\uff1a<\/strong> \u7d50\u5408\u653e\u5c04\u6cbb\u7642\u3001\u652f\u6301\u6cbb\u7642\u548c\u91dd\u5c0d\u8461\u8404\u7cd6\u548c\u9ea9\u91af\u80fa\u9178\u4ee3\u8b1d\u7684\u65b0\u8208\u4ee3\u8b1d\u7642\u6cd5\u3002\u901a\u5e38\u9f13\u52f5\u53c3\u8207\u81e8\u5e8a\u8a66\u9a57\u3002<\/li>\n<li><strong>\u5b58\u6d3b\u7387\uff1a<\/strong> \u4e0d\u9032\u884c\u5e79\u9810\u7684\u4e2d\u4f4d\u5b58\u6d3b\u671f\u7d04\u70ba 6-9 \u500b\u6708\u3002\u53ca\u6642\u958b\u59cb\u6a19\u9776\u6cbb\u7642\u53ef\u80fd\u6703\u5c07\u5b58\u6d3b\u671f\u5ef6\u9577\u8fd1 12-18 \u500b\u6708\u3002<\/li>\n<\/ul>\n<h3 id=\"stage-3-advanced-diffuse-intrinsic-pontine-glioma-dipg\">\u968e\u6bb5 3 \u2013 \u665a\u671f\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG)<\/h3>\n<p>\u5728\u665a\u671f\u968e\u6bb5\uff0cDIPG \u6703\u6025\u5287\u589e\u6b96\u4e26\u64f4\u6563\u5230\u521d\u59cb\u908a\u754c\u4e4b\u5916\uff0c\u5bc6\u5207\u5f71\u97ff\u9130\u8fd1\u7684\u8166\u5e79\u5340\u57df\u548c\u8166\u795e\u7d93\u3002\u60a3\u8005\u7684\u751f\u6d3b\u54c1\u8cea\u986f\u8457\u60e1\u5316\uff0c\u9700\u8981\u5168\u9762\u7684\u5b89\u5be7\u7642\u8b77\u548c\u75c7\u72c0\u7ba1\u7406\u3002<\/p>\n<ul>\n<li><strong>\u75be\u75c5\u9032\u5c55\uff1a<\/strong> \u8166\u5e79\u7d50\u69cb\u7684\u5ee3\u6cdb\u6d78\u6f64\u3002<\/li>\n<li><strong>\u75c7\u72c0\uff1a<\/strong> \u56b4\u91cd\u7684\u795e\u7d93\u529f\u80fd\u7f3a\u640d\u3001\u6d3b\u52d5\u53d7\u9650\u3001\u56b4\u91cd\u7684\u8a00\u8a9e\u548c\u541e\u56a5\u969c\u7919\u3001\u65e5\u5e38\u751f\u6d3b\u54c1\u8cea\u986f\u8457\u4e0b\u964d\u3002<\/li>\n<li><strong>\u6cbb\u7642\u65b9\u6cd5\uff1a<\/strong> \u591a\u6a21\u5f0f\u7ba1\u7406\uff0c\u5305\u62ec\u5f37\u5316\u75c7\u72c0\u548c\u652f\u6301\u6cbb\u7642\u3001\u5148\u9032\u7684\u4ee3\u8b1d\u6cbb\u7642\u548c\u9078\u5b9a\u7684\u5be6\u9a57\u6027\u81e8\u5e8a\u5e79\u9810\u63aa\u65bd\u3002<\/li>\n<li><strong>\u5b58\u6d3b\u7387\uff1a<\/strong> \u5118\u7ba1\u53cd\u61c9\u6027\u4ee3\u8b1d\u7642\u6cd5\u548c\u81e8\u5e8a\u8a66\u9a57\u53ef\u4ee5\u63d0\u4f9b\u66f4\u9577\u671f\u7684\u75c7\u72c0\u7ba1\u7406\uff0c\u4f46\u8a3a\u65b7\u5f8c\u7b2c 3 \u968e\u6bb5\u7684\u4e2d\u4f4d\u5b58\u6d3b\u671f\u5f98\u5f8a\u5728 6-12 \u500b\u6708\u5de6\u53f3\u3002<\/li>\n<\/ul>\n<h3 id=\"stage-4-metastatic-diffuse-intrinsic-pontine-glioma-dipg\">\u968e\u6bb5 4 \u2013 \u8f49\u79fb\u6027\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG)<\/h3>\n<p>\u8f49\u79fb\u6027 DIPG \u4ee3\u8868\u6700\u56b4\u91cd\u4e14\u6700\u5177\u6311\u6230\u6027\u7684\u9810\u5f8c\u3002\u816b\u7624\u7d30\u80de\u5728\u8166\u810a\u9ad3\u6db2\u4e2d\u6709\u6548\u64f4\u6563\u5230\u9060\u8655\u7684\u5927\u8166\u5340\u57df\u6216\u810a\u9ad3\u6bb5\uff0c\u70ba\u6cbb\u7642\u5e36\u4f86\u4e86\u6df1\u523b\u7684\u8907\u96dc\u6027\u3002<\/p>\n<ul>\n<li><strong>\u816b\u7624\u64f4\u6563\uff1a<\/strong> \u53ef\u89c0\u5bdf\u5230\u810a\u690e\u8f49\u79fb\u6216\u64f4\u6563\u5230\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u7684\u591a\u500b\u5340\u57df\u3002<\/li>\n<li><strong>\u75c7\u72c0\uff1a<\/strong> \u795e\u7d93\u529f\u80fd\u56b4\u91cd\u53d7\u640d\u3001\u56b4\u91cd\u547c\u5438\u56f0\u96e3\u3001\u5287\u70c8\u75bc\u75db\u3001\u865b\u5f31\u7121\u529b\u548c\u5171\u6fdf\u5931\u8abf\uff0c\u9700\u91cd\u75c7\u76e3\u8b77\u3002<\/li>\n<li><strong>\u6cbb\u7642\u6311\u6230\uff1a<\/strong> \u591a\u5b78\u79d1\u63aa\u65bd\u5305\u62ec\u5148\u9032\u7684\u4ee3\u8b1d\u8abf\u7bc0\u7642\u6cd5\uff08Warburg \u548c\u8c37\u6c28\u9170\u80fa\u4f9d\u8cf4\u6027\u9776\u5411\uff09\u3001\u7a4d\u6975\u7684\u75c7\u72c0\u548c\u59d1\u606f\u6cbb\u7642\u4ee5\u53ca\u7cfb\u7d71\u7ba1\u7406\u7684\u7814\u7a76\u8a66\u9a57\u3002<\/li>\n<li><strong>\u5b58\u6d3b\u7387\uff1a<\/strong> \u8f49\u79fb\u968e\u6bb5\u7684\u9810\u5f8c\u672c\u8cea\u4e0a\u4ecd\u7136\u56b4\u5cfb\uff0c\u4e2d\u4f4d\u7e3d\u5b58\u6d3b\u671f\u901a\u5e38\u4f4e\u65bc 6 \u500b\u6708\u3002\u7136\u800c\uff0c\u7cbe\u78ba\u6a19\u9776\u7684\u4ee3\u8b1d\u6cbb\u7642\u6b63\u5728\u6df1\u5165\u7814\u7a76\u548c\u8a66\u9a57\uff0c\u4eba\u5011\u5c0d 2025 \u5e74\u5c07 DIPG \u8f49\u8b8a\u70ba\u66f4\u6162\u6027\u7684\u63a7\u5236\u75be\u75c5\u7684\u76ee\u6a19\u5bc4\u4e88\u539a\u671b\u3002<\/li>\n<\/ul>\n<p>\u4e86\u89e3\u5206\u671f\u6709\u52a9\u65bc\u5bb6\u5ead\u548c\u91ab\u7642\u4fdd\u5065\u63d0\u4f9b\u8005\u4e3b\u52d5\u63a5\u89f8 DIPG\uff0c\u5f9e\u800c\u505a\u51fa\u660e\u667a\u7684\u6cbb\u7642\u6c7a\u7b56\u3002\u4ee3\u8b1d\u816b\u7624\u5b78\u3001\u7cbe\u6e96\u653e\u5c04\u6cbb\u7642\u548c\u6709\u91dd\u5c0d\u6027\u7684\u60a3\u8005\u8b77\u7406\u65b9\u6848\u7684\u4e0d\u65b7\u9032\u6b65\u5e36\u4f86\u4e86\u65b0\u7684\u5e0c\u671b\uff0c\u5373\u4e00\u5ea6\u88ab\u8a8d\u70ba\u4e0d\u53ef\u907f\u514d\u81f4\u547d\u7684 DIPG \u53ef\u4ee5\u8b8a\u5f97\u53ef\u63a7\uff0c\u8207\u5c07\u4ee5\u524d\u81f4\u547d\u7684\u764c\u75c7\u8f49\u5316\u70ba\u6162\u6027\u75be\u75c5\u7684\u52aa\u529b\u76f8\u4e00\u81f4\u3002<\/p>\n<p>\u7acb\u5373\u63a2\u7d22\u6709\u6548\u7684 DIPG \u6cbb\u7642\u5275\u65b0\uff1a <a href=\"\/zh-hk\/treatment-cancer\/\">\u63a2\u7d22\u5148\u9032\u7684 DIPG \u7642\u6cd5\u3002<\/a><\/p>\n<h2 id=\"limitations-of-traditional-therapies-for-diffuse-intrinsic-pontine-glioma-dipg\">\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG) \u50b3\u7d71\u7642\u6cd5\u7684\u5c40\u9650\u6027<\/h2>\n<h3 id=\"understanding-the-challenges-of-conventional-dipg-therapies\">\u4e86\u89e3\u50b3\u7d71 DIPG \u7642\u6cd5\u7684\u6311\u6230<\/h3>\n<p>\u7528\u65bc\u6cbb\u7642\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624 (DIPG) \u7684\u50b3\u7d71\u65b9\u6cd5\uff08\u4e3b\u8981\u662f\u5316\u7642\u3001\u653e\u7642\u548c\u624b\u8853\u5e79\u9810\uff09\u7e7c\u7e8c\u5e36\u4f86\u91cd\u5927\u7684\u6cbb\u7642\u548c\u5b89\u5168\u6311\u6230\u3002\u5118\u7ba1\u6709\u8c50\u5bcc\u7684\u81e8\u5e8a\u7d93\u9a57\uff0c\u73fe\u6709\u7684\u6cbb\u7642\u65b9\u6cd5\u901a\u5e38\u5b58\u5728\u76f8\u7576\u5927\u7684\u5c40\u9650\u6027\uff0c\u5305\u62ec\u56b4\u91cd\u7684\u6bd2\u6027\u3001\u6709\u9650\u7684\u7642\u6548\u4ee5\u53ca\u5c0d\u60a3\u8005\u751f\u6d3b\u54c1\u8cea\u7684\u8ca0\u9762\u5f71\u97ff\u3002<\/p>\n<h3 id=\"chemotherapy-s-high-toxicity-and-limited-effectiveness\">\u5316\u7642\u7684\u9ad8\u6bd2\u6027\u548c\u6709\u9650\u7684\u6548\u679c<\/h3>\n<p>\u5316\u7642\u4ecd\u7136\u662f DIPG \u5ee3\u6cdb\u7684\u5e38\u898f\u6cbb\u7642\u65b9\u6cd5\u3002\u7136\u800c\uff0c\u5b83\u7684\u4f7f\u7528\u6703\u5e36\u4f86\u56b4\u91cd\u7684\u526f\u4f5c\u7528\uff0c\u56b4\u91cd\u640d\u5bb3\u60a3\u8005\u7684\u5065\u5eb7\u548c\u8212\u9069\u5ea6\u3002\u7814\u7a76\u8868\u660e\uff0c\u9ad8\u9054 78% \u63a5\u53d7\u50b3\u7d71\u5316\u7642\u85e5\u7269\u7684\u60a3\u8005\u6703\u51fa\u73fe\u660e\u986f\u7684\u9aa8\u9ad3\u6291\u5236\uff0c\u5c0e\u81f4\u4ee5\u4e0b\u4f75\u767c\u75c7\uff1a<\/p>\n<ul>\n<li>\u767d\u8840\u7403\u8a08\u6578\u6e1b\u5c11\u5c0e\u81f4\u611f\u67d3\u98a8\u96aa\u589e\u52a0<\/li>\n<li>\u56b4\u91cd\u8ca7\u8840\u5c0e\u81f4\u6975\u5ea6\u75b2\u52de<\/li>\n<li>\u8840\u5c0f\u677f\u7f3a\u4e4f\u5c0e\u81f4\u7600\u50b7\u548c\u51fa\u8840\u7684\u98a8\u96aa\u589e\u52a0<\/li>\n<\/ul>\n<p>\u6b64\u5916\uff0c\u8fd1 23% \u7684\u63a5\u53d7\u6cbb\u7642\u7684\u60a3\u8005\u51fa\u73fe\u5fc3\u81df\u6bd2\u6027\uff0c\u9019\u6975\u5927\u5730\u9650\u5236\u4e86\u85e5\u7269\u7684\u7d66\u85e5\u548c\u6cbb\u7642\u6301\u7e8c\u6642\u9593\u3002\u5728\u665a\u671f\u6216\u8f49\u79fb\u6027 DIPG \u75c5\u4f8b\u4e2d\uff0c\u5316\u7642\u6548\u679c\u6025\u5287\u4e0b\u964d\uff0c\u7814\u7a76\u8a18\u9304\u5ba2\u89c0\u7de9\u89e3\u7387\u4f4e\u65bc 21%\uff0c\u986f\u793a\u8feb\u5207\u9700\u8981\u5275\u65b0\u4e14\u6bd2\u6027\u8f03\u5c0f\u7684\u6cbb\u7642\u65b9\u6cd5\u4f86\u6cbb\u7642 DIPG\u3002<\/p>\n<p>\u5728\u9999\u6e2f\u548c\u6574\u500b\u4e9e\u6d32\uff0c\u50b3\u7d71\u5316\u7642\u4ecd\u7136\u5f88\u5e38\u898b\uff0c\u4f46\u7531\u65bc\u91ab\u7642\u8cc7\u6e90\u9650\u5236\u548c\u5340\u57df\u91ab\u7642\u57fa\u790e\u8a2d\u65bd\u56fa\u6709\u7684\u60a3\u8005\u7ba1\u7406\u9650\u5236\uff0c\u6bd2\u6027\u8ca0\u64d4\u8b8a\u5f97\u8d8a\u4f86\u8d8a\u5177\u6709\u6311\u6230\u6027\u3002<\/p>\n<h3 id=\"radiotherapy-associated-serious-side-effects-in-dipg-treatments\">DIPG \u6cbb\u7642\u4e2d\u653e\u5c04\u6cbb\u7642\u76f8\u95dc\u7684\u56b4\u91cd\u526f\u4f5c\u7528<\/h3>\n<p>\u7531\u65bc DIPG \u6700\u521d\u5177\u6709\u7e2e\u5c0f\u816b\u7624\u7684\u529f\u6548\uff0c\u56e0\u6b64\u7d93\u5e38\u5c0d DIPG \u9032\u884c\u653e\u5c04\u6cbb\u7642\u3002\u5118\u7ba1\u5982\u6b64\uff0c\u8f3b\u5c04\u526f\u4f5c\u7528\u56b4\u91cd\u5f71\u97ff\u60a3\u8005\u7684\u8eab\u9ad4\u5065\u5eb7\u548c\u65e5\u5e38\u751f\u6d3b\u6d3b\u52d5\u3002\u7d93\u5e38\u89c0\u5bdf\u5230\u7684\u5e38\u898b\u8f3b\u5c04\u5f15\u8d77\u7684\u554f\u984c\u5305\u62ec\uff1a<\/p>\n<ul>\n<li>\u5c40\u90e8\u7d44\u7e54\u640d\u50b7\uff0c\u53ef\u80fd\u5c0e\u81f4\u795e\u7d93\u529f\u80fd\u7f3a\u640d<\/li>\n<li>\u75b2\u52de\u548c\u5168\u8eab\u865b\u5f31\uff0c\u5f71\u97ff\u751f\u6d3b\u54c1\u8cea<\/li>\n<li>\u5641\u5fc3\u548c\u53ad\u98df\uff0c\u52a0\u5287\u60a3\u8005\u71df\u990a\u72c0\u6cc1\u554f\u984c<\/li>\n<li>\u7e7c\u767c\u6027\u60e1\u6027\u816b\u7624\u7684\u98a8\u96aa\u589e\u52a0\u2014\u6839\u64da\u300a\u7f8e\u570b\u91ab\u5b78\u6703\u96dc\u8a8c\u816b\u7624\u5b78\u300b\uff082023 \u5e74\uff09\u6700\u8fd1\u767c\u8868\u7684\u7814\u7a76\u5831\u544a\u7a31\uff0c\u7e7c\u767c\u6027\u60e1\u6027\u816b\u7624\u7684\u98a8\u96aa\u589e\u52a0\u4e86 300%<\/li>\n<\/ul>\n<p>\u9019\u4e9b\u653e\u5c04\u76f8\u95dc\u4f75\u767c\u75c7\u7684\u6301\u7e8c\u5b58\u5728\u548c\u56b4\u91cd\u7a0b\u5ea6\u9032\u4e00\u6b65\u51f8\u986f\u4e86\u653e\u5c04\u6cbb\u7642\u4f5c\u70ba\u7d9c\u5408 DIPG \u6cbb\u7642\u7684\u9650\u5236\u3002\u9451\u65bc DIPG \u5728\u8166\u5e79\u5167\u7684\u95dc\u9375\u4f4d\u7f6e\uff0c\u8f3b\u5c04\u7684\u6709\u5bb3\u5f71\u97ff\u53ef\u80fd\u6703\u56b4\u91cd\u640d\u5bb3\u795e\u7d93\u529f\u80fd\uff0c\u56b4\u91cd\u9650\u5236\u60a3\u8005\u7684\u9577\u671f\u8a8d\u77e5\u548c\u8eab\u9ad4\u80fd\u529b\u3002<\/p>\n<h3 id=\"surgical-risks-and-limitations-in-diffuse-intrinsic-pontine-glioma\">\u7030\u6f2b\u6027\u5167\u6e90\u6027\u8166\u6a4b\u81a0\u8cea\u7624\u7684\u624b\u8853\u98a8\u96aa\u548c\u5c40\u9650\u6027<\/h3>\n<p>\u7531\u65bc DIPG \u7684\u7030\u6f2b\u6027\u751f\u9577\u6a21\u5f0f\u548c\u8106\u5f31\u7684\u8166\u5e79\u4f4d\u7f6e\uff0c\u624b\u8853\u4ecb\u5165\u5177\u6709\u76f8\u7576\u5927\u7684\u98a8\u96aa\u548c\u9650\u5236\u3002<\/p>\n<ul>\n<li>\u624b\u8853\u5f8c\u56b4\u91cd\u611f\u67d3\u7684\u98a8\u96aa\u5f88\u9ad8<\/li>\n<li>\u624b\u8853\u671f\u9593\u548c\u8853\u5f8c\u7684\u795e\u7d93\u640d\u50b7\u98a8\u96aa\uff0c\u53ef\u80fd\u5f71\u97ff\u91cd\u8981\u7684\u8166\u5e79\u529f\u80fd<\/li>\n<li>\u7531\u65bc\u624b\u8853\u5340\u57df\u8106\u5f31\uff0c\u9650\u5236\u4e86\u816b\u7624\u7d44\u7e54\u7684\u5b8c\u5168\u63d0\u53d6\uff0c\u56e0\u6b64\u767c\u75c5\u7387\u5f88\u9ad8<\/li>\n<\/ul>\n<p>\u56e0\u6b64\uff0cDIPG \u7684\u624b\u8853\u4e3b\u8981\u9650\u65bc\u6d3b\u6aa2\u7a0b\u5e8f\uff0c\u6e1b\u5c11\u4e86\u6f5b\u5728\u7684\u6cbb\u7642\u76ca\u8655\uff0c\u4e26\u5f37\u8abf\u4e86\u5c08\u70ba DIPG \u75c5\u7406\u5b78\u8a2d\u8a08\u7684\u4fb5\u5165\u6027\u8f03\u5c0f\u3001\u66f4\u6709\u6548\u7684\u7642\u6cd5\u7684\u52d5\u529b\u3002<\/p>\n<h3 id=\"metabolic-resistance-mechanisms-hampering-conventional-dipg-treatments\">\u963b\u7919\u50b3\u7d71 DIPG \u6cbb\u7642\u7684\u4ee3\u8b1d\u62b5\u6297\u6a5f\u5236<\/h3>\n<p>\u50b3\u7d71\u6cbb\u7642\u7684\u4e00\u500b\u95dc\u9375\u9650\u5236\u4f86\u81ea\u65bc DIPG \u7d30\u80de\u672c\u8eab\u7684\u62b5\u6297\u4ee3\u8b1d\u7279\u6027\u3002 DIPG \u5177\u6709\u986f\u8457\u7684\u4ee3\u8b1d\u53ef\u5851\u6027\uff0c\u5c24\u5176\u662f Warburg \u6548\u61c9\uff0c\u5373\u764c\u7d30\u80de\u6d88\u8017\u8461\u8404\u7cd6\u7684\u901f\u5ea6\u6bd4\u6b63\u5e38\u7d30\u80de\u5feb\u8fd1 200 \u500d\uff0c\u4e26\u4e14\u751f\u9577\u5c0d\u8c37\u6c28\u9170\u80fa\u7684\u4f9d\u8cf4\u7a0b\u5ea6\u66f4\u9ad8\u3002<\/p>\n<p>\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0c\u8207\u5065\u5eb7\u7d44\u7e54\u76f8\u6bd4\uff0cDIPG \u7d30\u80de\u7684 DNA \u4fee\u5fa9\u9176\u6d3b\u6027\u589e\u52a0\u4e86\u8fd1 400%\u3002\u9019\u4e9b\u904e\u5ea6\u6d3b\u8e8d\u7684\u4fee\u5fa9\u6a5f\u5236\u5927\u5927\u964d\u4f4e\u4e86\u50b3\u7d71\u5316\u7642\u548c\u653e\u7642\u7684\u6709\u6548\u6027\u3002\u56e0\u6b64\uff0cDIPG \u7d30\u80de\u80fd\u8fc5\u901f\u5f9e\u653e\u5c04\u7dda\u8a98\u5c0e\u548c\u5316\u7642\u76f8\u95dc\u7684 DNA \u640d\u50b7\u4e2d\u6062\u5fa9\uff0c\u56b4\u91cd\u9650\u5236\u6cbb\u7642\u6548\u679c\u4e26\u589e\u52a0\u764c\u75c7\u5fa9\u767c\u98a8\u96aa\u3002<\/p>\n<h3 id=\"psychosocial-and-quality-of-life-challenges-related-to-traditional-dipg-therapy\">\u8207\u50b3\u7d71 DIPG \u7642\u6cd5\u76f8\u95dc\u7684\u5fc3\u7406\u793e\u6703\u548c\u751f\u6d3b\u54c1\u8cea\u6311\u6230<\/h3>\n<p>\u9664\u4e86\u91ab\u7642\u4f75\u767c\u75c7\u4e4b\u5916\uff0c\u50b3\u7d71\u7684\u6cbb\u7642\u65b9\u6cd5\u4e5f\u986f\u8457\u5f71\u97ff\u60a3\u8005\u548c\u7167\u8b77\u8005\u7684\u5fc3\u7406\u548c\u60c5\u7dd2\u5065\u5eb7\u3002\u50b3\u7d71\u7642\u6cd5\u901a\u5e38\u6703\u5c0e\u81f4\uff1a<\/p>\n<ul>\n<li>\u6162\u6027\u75b2\u52de\u6703\u524a\u5f31\u60a3\u8005\u7684\u60c5\u7dd2\u548c\u793e\u4ea4\u4e92\u52d5<\/li>\n<li>\u6301\u7e8c\u5641\u5fc3\u56b4\u91cd\u5f71\u97ff\u60a3\u8005\u7684\u71df\u990a\u651d\u53d6\u8207\u751f\u6d3b\u54c1\u8cea<\/li>\n<li>\u7531\u65bc\u6cbb\u7642\u5f37\u5ea6\u548c\u6301\u7e8c\u7684\u5065\u5eb7\u4e0d\u78ba\u5b9a\u6027\u800c\u9020\u6210\u9ad8\u5ea6\u60c5\u7dd2\u548c\u7cbe\u795e\u56f0\u64fe<\/li>\n<\/ul>\n<p>\u5728\u5305\u62ec\u9999\u6e2f\u5728\u5167\u7684\u4e9e\u6d32\u793e\u5340\uff0c\u6587\u5316\u5dee\u7570\u548c\u793e\u6703\u6065\u8fb1\u9032\u4e00\u6b65\u589e\u52a0\u4e86\u8907\u96dc\u6027\uff0c\u53ef\u80fd\u6703\u589e\u52a0\u5b64\u7acb\u611f\uff0c\u4e26\u5728\u9577\u671f\u6cbb\u7642\u671f\u9593\u52a0\u5287\u5bb6\u5ead\u7684\u60c5\u611f\u8ca0\u64d4\u3002<\/p>\n<h3 id=\"challenges-specific-to-hong-kong-and-asia-in-treating-dipg\">\u9999\u6e2f\u548c\u4e9e\u6d32\u5728\u6cbb\u7642 DIPG \u65b9\u9762\u9762\u81e8\u7684\u7279\u6b8a\u6311\u6230<\/h3>\n<p>\u5728\u9999\u6e2f\u548c\u5176\u4ed6\u4e9e\u6d32\u5730\u5340\uff0c\u7531\u65bc\u5177\u9ad4\u60c5\u6cc1\u7684\u6311\u6230\uff0cDIPG \u5316\u5408\u7269\u7684\u6cbb\u7642\u53d7\u5230\u9650\u5236\uff1a<\/p>\n<ul>\n<li>\u80fd\u5920\u7ba1\u7406\u9ad8\u7d1a DIPG \u75c5\u4f8b\u7684\u5c08\u9580\u5152\u79d1\u816b\u7624\u79d1\u55ae\u4f4d\u7684\u4f7f\u7528\u6a5f\u6703\u6709\u9650<\/li>\n<li>\u7528\u65bc\u7ba1\u7406\u8207\u5316\u7642\u548c\u653e\u7642\u76f8\u95dc\u7684\u56b4\u91cd\u526f\u4f5c\u7528\u7684\u652f\u6301\u6027\u8b77\u7406\u8a2d\u65bd\u4e0d\u8db3<\/li>\n<li>\u60a3\u8005\u548c\u7167\u8b77\u8005\u5c0d\u5168\u7403\u6700\u8fd1\u51fa\u73fe\u7684\u65b0\u578b\u4ee3\u8b1d\u548c\u6a19\u9776\u7642\u6cd5\u7684\u8a8d\u8b58\u8f03\u5c11<\/li>\n<\/ul>\n<p>\u9019\u4e9b\u7279\u5b9a\u5730\u5340\u7684\u5dee\u8ddd\u51f8\u986f\u4e86\u8feb\u5207\u9700\u8981\u52a0\u5f37\u6559\u80b2\u8209\u63aa\u3001\u8cc7\u6e90\u5206\u914d\u3001\u5168\u7403\u816b\u7624\u5b78\u5c08\u5bb6\u4e4b\u9593\u52a0\u5f37\u5408\u4f5c\uff0c\u4ee5\u53ca\u5728 DIPG \u7ba1\u7406\u4e2d\u63a1\u7528\u6700\u65b0\u7684\u7814\u7a76\u652f\u6301\u7684\u764c\u75c7\u7b56\u7565\u3002<\/p>\n<h3 id=\"a-critical-need-for-better-dipg-therapies\">\u8feb\u5207\u9700\u8981\u66f4\u597d\u7684 DIPG \u7642\u6cd5\uff1a<\/h3>\n<p>\u6beb\u7121\u7591\u554f\uff0c\u50b3\u7d71\u7684 DIPG \u6cbb\u7642\u65b9\u6cd5\u63d0\u4f9b\u7684\u81e8\u5e8a\u76ca\u8655\u6709\u9650\uff0c\u540c\u6642\u4e5f\u5b58\u5728\u5de8\u5927\u7684\u98a8\u96aa\u3002\u96a8\u8457\u6211\u5011\u5728\u674e\u570b\u83ef\u535a\u58eb\u7b49\u5168\u7403\u77e5\u540d\u7814\u7a76\u4eba\u54e1\u4ee5\u53ca\u827e\u5229\u68ee\u548c\u585e\u9580\u624e\u7b49\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u7684\u652f\u6301\u4e0b\u5728\u4ee3\u8b1d\u816b\u7624\u5b78\u65b9\u9762\u53d6\u5f97\u9032\u5c55\uff0c\u63a2\u7d22\u898f\u907f\u50b3\u7d71\u5c40\u9650\u6027\u7684\u6a19\u9776\u6cbb\u7642\u8b8a\u5f97\u81f3\u95dc\u91cd\u8981\u3002\u5fc5\u9808\u5229\u7528\u4ee3\u8b1d\u7642\u6cd5\u3001\u514d\u75ab\u7642\u6cd5\u548c\u6a19\u9776\u5206\u5b50\u65b9\u6cd5\u7684\u6700\u65b0\u5275\u65b0\u4f86\u91cd\u65b0\u5b9a\u7fa9 DIPG \u8b77\u7406\u6a19\u6e96\u4e26\u5168\u9762\u6539\u5584\u9810\u5f8c\u548c\u60a3\u8005\u751f\u6d3b\u54c1\u8cea\u3002<\/p>\n<h2>\u56db\u7dad\u7121\u6bd2\u764c\u75c7\u7642\u6cd5\u6cbb\u7642\u65b9\u6cd5<\/h2>\n<p>\u9999\u6e2f\u4ee3\u8b1d\u816b\u7624\u6cbb\u7642\u4e2d\u5fc3\u63d0\u51fa\u7684\u56db\u7dad\u7121\u6bd2\u7642\u6cd5\u4ee3\u8868\u4e86\u4e00\u7a2e\u591a\u5c64\u9762\u7684\u764c\u75c7\u6cbb\u7642\u65b9\u6cd5\uff0c\u65e8\u5728\u5c07\u764c\u75c7\u8f49\u8b8a\u70ba\u53ef\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\u3002\u672c\u8abf\u67e5\u5831\u544a\u57fa\u65bc\u6240\u63d0\u4f9b\u7684\u6587\u4ef6\uff0c\u4e26\u900f\u904e\u57fa\u65bc\u7db2\u8def\u7684\u79d1\u5b78\u6587\u737b\u7684\u5ee3\u6cdb\u7814\u7a76\u9032\u884c\u4e86\u88dc\u5145\uff0c\u5c0d\u56db\u7a2e\u65b9\u6cd5\uff08\u4ee3\u8b1d\u6291\u5236\u3001\u7bc0\u5f8b\u6027\u816b\u7624\u63a7\u5236\u3001\u57fa\u56e0\u9776\u5411\u65ac\u9996\u548c\u514d\u75ab\u98a8\u66b4\u6fc0\u6d3b\uff09\u9032\u884c\u4e86\u5168\u9762\u5206\u6790\u3002\u5206\u6790\u5305\u62ec\u79d1\u5b78\u539f\u7406\u3001\u81e8\u5e8a\u8b49\u64da\u548c\u6f5b\u5728\u6311\u6230\uff0c\u6700\u7d42\u63d0\u51fa\u4e86\u53e3\u865f\u548c\u53e3\u865f\u3002<\/p>\n<h3>\u4ee3\u8b1d\u6291\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u9019\u7a2e\u65b9\u6cd5\u91dd\u5c0d\u764c\u7d30\u80de\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u7279\u5225\u662f\u5b83\u5011\u5c0d\u8461\u8404\u7cd6\u3001\u9ea9\u91af\u80fa\u9178\u548c\u8102\u8cea\u5408\u6210\u7684\u4f9d\u8cf4\u3002\u5b83\u4f7f\u7528\u8af8\u5982\u7528\u65bc\u8461\u8404\u7cd6\u8f49\u904b\u7684 GLUT1\/3\u3001\u7528\u65bc\u8c37\u6c28\u9170\u80fa\u4ee3\u8b1d\u7684 GLS\/ASCT2 \u4ee5\u53ca\u7528\u65bc\u8102\u8cea\u5408\u6210\u7684 FASN \u7b49\u6291\u5236\u5291\uff0c\u901a\u5e38\u900f\u904e\u5948\u7c73\u8f09\u9ad4\u905e\u9001\u3002\u4eba\u5de5\u667a\u6167\u9a45\u52d5\u7684\u71df\u990a\u8abf\u7bc0\u63d0\u9ad8\u4e86\u7cbe\u78ba\u5ea6\uff0c\u65e8\u5728\u5f15\u767c ATP \u5371\u6a5f\u4e26\u524a\u5f31\u764c\u7d30\u80de\u3002\u6587\u4ef6\u8072\u7a31\u816b\u7624\u8461\u8404\u7cd6\u651d\u53d6\u6e1b\u5c11\u4e86 82%\uff0c\u8840\u6f3f\u9ea9\u91af\u80fa\u9178\u6e1b\u5c11\u4e86 79%\uff0c\u819c\u78f7\u8102\u5408\u6210\u6e1b\u5c11\u4e86 91%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u7814\u7a76\uff0c\u4f8b\u5982 <a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a>\uff0c\u8b49\u5be6\u764c\u7d30\u80de\u8868\u73fe\u51fa\u4ee3\u8b1d\u6539\u8b8a\uff0c\u5305\u62ec\u74e6\u4f2f\u683c\u6548\u61c9\uff08\u6709\u6c27\u7cd6\u89e3\uff09\u548c\u9ea9\u91af\u80fa\u9178\u6210\u766e\u3002 GLUT1\/3 \u548c GLS \u7b49\u6291\u5236\u5291\u6b63\u5728\u7814\u7a76\u4e2d <em>\u7d30\u80de\u4ee3\u8b1d<\/em> (2023) \u986f\u793a\u764c\u7d30\u80de\u4e2d\u7684\u4ee3\u8b1d\u58d3\u529b\u8a98\u5c0e\u3002\u5948\u7c73\u9846\u7c92\u8f38\u9001\u7cfb\u7d71\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a>\uff0c\u589e\u5f37\u7279\u7570\u6027\uff0c\u5118\u7ba1\u816b\u7624\u7570\u8cea\u6027\u548c\u812b\u9776\u6548\u61c9\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u6240\u8072\u7a31\u7684\u81e8\u5e8a\u76ca\u8655\u8207\u65b0\u8208\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u764c\u75c7\u985e\u578b\uff08\u4f8b\u5982\u80ba\u764c\u8207\u4e73\u764c\uff09\u548c\u60a3\u8005\u53cd\u61c9\u7684\u5dee\u7570\u8868\u660e\u9700\u8981\u500b\u6027\u5316\u7684\u65b9\u6cd5\u3002 2024\u5e74 <em>\u7d30\u80de<\/em> \u6587\u4ef6\u4e2d\u5f15\u7528\u7684\u7814\u7a76\u8072\u7a31\u6297\u85e5\u6027\u57fa\u56e0\u8868\u73fe\u6e1b\u5c11\u4e86 80%\uff0c\u9700\u8981\u900f\u904e\u66f4\u5927\u898f\u6a21\u7684\u591a\u4e2d\u5fc3\u8a66\u9a57\u9032\u884c\u9a57\u8b49\u3002\u502b\u7406\u65b9\u9762\u7684\u8003\u616e\uff0c\u4f8b\u5982\u7372\u53d6\u548c\u8ca0\u64d4\u80fd\u529b\uff0c\u5728 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2949723X23000533\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a>.<\/p>\n<h3>\u7bc0\u5f8b\u6027\u816b\u7624\u63a7\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u4f4e\u5291\u91cf\u3001\u7bc0\u5f8b\u5316\u7642\uff08\u50b3\u7d71\u5291\u91cf\u7684 1\/10\uff09\u548c\u8840\u7ba1\u6b63\u5e38\u5316\u56e0\u5b50\u4f86\u63a7\u5236\u816b\u7624\u751f\u9577\uff0c\u964d\u4f4e\u6bd2\u6027\u4e26\u5be6\u73fe 67% \u7684\u5bb6\u5ead\u6cbb\u7642\u3002\u64da\u8072\u7a31\uff0c\u5b83\u5c07\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u5f9e 5.2 \u500b\u6708\u5ef6\u9577\u81f3 11.8 \u500b\u6708\uff0c\u4e26\u5c07\u56b4\u91cd\u6bd2\u6027\u964d\u4f4e 67%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u4f4e\u5291\u91cf\u7bc0\u5f8b\u5316\u7642\u5df2\u88ab\u5ee3\u6cdb\u63a5\u53d7\uff0c\u5982 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a>\uff0c\u91dd\u5c0d\u816b\u7624\u8840\u7ba1\u751f\u6210\u548c\u514d\u75ab\u8abf\u7bc0\u3002\u8840\u7ba1\u6b63\u5e38\u5316\uff0c\u652f\u6301 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a>\uff0c\u900f\u904e\u589e\u5f37\u8840\u7ba1\u529f\u80fd\u4f86\u6539\u5584\u85e5\u7269\u8f38\u9001\u3002\u7814\u7a76\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a> \u78ba\u8a8d\u6e1b\u5c11\u7684\u526f\u4f5c\u7528\u548c\u6f5b\u5728\u7684\u6210\u672c\u6548\u76ca\uff0c\u7279\u5225\u662f\u5728\u4f4e\u6536\u5165\u74b0\u5883\u4e2d\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u76ca\u8655\u8207\u8f49\u79fb\u6027\u4e73\u764c\u7684\u81e8\u5e8a\u6578\u64da\u4e00\u81f4\uff0c\u4f46\u7642\u6548\u53ef\u80fd\u56e0\u816b\u7624\u985e\u578b\u548c\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u800c\u7570\u3002\u5bb6\u5ead\u6cbb\u7642\u6a21\u5f0f\u96d6\u7136\u6709\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u5805\u6301\u548c\u76e3\u6e2c\uff0c\u5982 <a href=\"https:\/\/www.lifespringcancercenter.com\/our-treatment\/low-dose-metronomic-chemotherapy\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a>\u3002\u95dc\u65bc\u6297\u85e5\u6027\u548c\u751f\u6d3b\u54c1\u8cea\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u63a2\u7d22\u3002<\/p>\n<h3>\u57fa\u56e0\u6a19\u9776\u65ac\u9996<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u6db2\u9ad4\u6d3b\u6aa2\u4f86\u6aa2\u6e2c 487 \u500b\u764c\u75c7\u9a45\u52d5\u57fa\u56e0\uff0c\u4e26\u4f7f\u7528\u5948\u7c73\u9846\u7c92\u905e\u9001\u7cfb\u7d71\u4f86\u9776\u5411 KRAS\u3001BRAF \u548c TP53 \u7b49\u7a81\u8b8a\uff0c\u5f9e\u800c\u514b\u670d\u8840\u8166\u5c4f\u969c\u7b49\u969c\u7919\u3002\u5b83\u8072\u7a31 ORR \u63d0\u9ad8\u4e86 67%\uff0c\u905e\u9001\u6548\u7387\u63d0\u9ad8\u4e86 9 \u500d\uff0c\u7279\u5225\u662f\u5c0d\u65bc\u8f49\u79fb\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u5948\u7c73\u9846\u7c92\u8f38\u9001\u662f\u4e00\u500b\u524d\u6cbf\u9818\u57df\uff0c <a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a> \u5f37\u8abf\u5176\u7a7f\u900f\u751f\u7406\u5c4f\u969c\u7684\u80fd\u529b\u3002\u6db2\u9ad4\u6d3b\u6aa2\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a>\uff0c\u5be6\u73fe\u5373\u6642\u7a81\u8b8a\u6aa2\u6e2c\uff0c\u8207\u7cbe\u6e96\u816b\u7624\u5b78\u8da8\u52e2\u4fdd\u6301\u4e00\u81f4\u3002\u7814\u7a76\u65bc <a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a> \u5118\u7ba1\u6bd2\u6027\u548c\u9776\u5411\u7279\u7570\u6027\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\uff0c\u4f46\u5b83\u986f\u793a\u51fa\u6cbb\u7642\u8166\u8f49\u79fb\u7684\u5e0c\u671b\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684 ORR \u70ba 67% \u662f\u96c4\u5fc3\u52c3\u52c3\u7684\uff0c\u96d6\u7136\u65e9\u671f\u8a66\u9a57\u986f\u793a\u51fa\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u66f4\u5927\u898f\u6a21\u7684\u7814\u7a76\u4f86\u9a57\u8b49\u8de8\u816b\u7624\u985e\u578b\u7684\u7642\u6548\u3002\u816b\u7624\u7570\u8cea\u6027\uff0c\u5982\u4e2d\u6240\u8ff0 <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-023-01865-0\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a>\uff0c\u53ef\u80fd\u6703\u9650\u88fd\u6210\u529f\uff0c\u9700\u8981\u7d44\u5408\u7b56\u7565\u3002<\/p>\n<h3>\u514d\u75ab\u98a8\u66b4\u6fc0\u6d3b<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528 PD-1\/CTLA-4 \u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u3001CAR-NK \u7d30\u80de\u548c\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\u4f86\u6d3b\u5316\u591a\u5c64\u514d\u75ab\u53cd\u61c9\u3002\u5b83\u8072\u7a31 3 \u5e74\u5b58\u6d3b\u7387\u70ba 62.7%\uff08\u6539\u5584\u4e86 244%\uff09\uff0c\u5fa9\u767c\u7387\u964d\u4f4e\u4e86 85%\uff0c\u5c07\u300c\u51b7\u300d\u816b\u7624\u8f49\u8b8a\u70ba\u300c\u71b1\u300d\u816b\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u806f\u5408\u514d\u75ab\u7642\u6cd5\u662f\u9818\u5148\u9818\u57df\uff0c <a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a> \u986f\u793a\u51fa\u589e\u5f37\u7684\u53cd\u61c9\u3002\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u548c CAR-T\/NK \u7642\u6cd5\uff0c\u53c3\u898b <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a>\u3001\u63d0\u9ad8\u514d\u75ab\u8fa8\u8b58\u80fd\u529b\u3002\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\uff0c\u7a81\u51fa\u986f\u793a\u65bc <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a>\uff0c\u5f71\u97ff\u514d\u75ab\u6cbb\u7642\u7684\u7d50\u679c\uff0c\u5118\u7ba1\u5176\u4e00\u81f4\u6027\u6709\u722d\u8b70\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u751f\u5b58\u7387\u8207\u6700\u8fd1\u7684\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u5be6\u9ad4\u7624\u7531\u65bc\u7570\u8cea\u6027\u548c\u514d\u75ab\u6291\u5236\u5fae\u74b0\u5883\u800c\u5e36\u4f86\u6311\u6230\uff0c\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a>\u3002\u95dc\u65bc\u5fa9\u767c\u548c\u514d\u75ab\u8a18\u61b6\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u9a57\u8b49\u3002<\/p>\n<h3>\u6bd4\u8f03\u81e8\u5e8a\u7d50\u679c<\/h3>\n<p>\u9019\u4e9b\u6587\u4ef6\u63d0\u4f9b\u4e86\u4e00\u500b\u6bd4\u8f03\u50b3\u7d71\u7642\u6cd5\u548c\u56db\u7dad\u7642\u6cd5\u7684\u8868\u683c\uff0c\u70ba\u6e05\u695a\u8d77\u898b\uff0c\u5c07\u5176\u8907\u88fd\u5982\u4e0b\uff1a<\/p>\n<figure>\n<table class=\"has-fixed-layout\">\n<tbody>\n<tr>\n<td>\u6307\u6a19<\/td>\n<td>\u50b3\u7d71\u7684<br \/>\u6cbb\u7642<\/td>\n<td>\u56db\u7dad<br \/>\u6cbb\u7642<\/td>\n<td>\u6539\u9032<\/td>\n<\/tr>\n<tr>\n<td>\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR)<\/td>\n<td>31%<\/td>\n<td>67%<\/td>\n<td>\u2191116%<\/td>\n<\/tr>\n<tr>\n<td>3 \u5e74\u5b58\u6d3b\u7387<\/td>\n<td>18%<\/td>\n<td>62.70%<\/td>\n<td>\u2191244%<\/td>\n<\/tr>\n<tr>\n<td>\u56b4\u91cd\u526f\u4f5c\u7528\u7387<\/td>\n<td>58%<\/td>\n<td>19%<\/td>\n<td>\u219367%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\u8868\u683c\u5f37\u8abf\u4e86\u8a72\u7642\u6cd5\u7684\u6f5b\u529b\uff0c\u4f46\u60a3\u8005\u7fa4\u9ad4\u548c\u816b\u7624\u985e\u578b\u4e4b\u9593\u7684\u5dee\u7570\u503c\u5f97\u9032\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n<h2><strong>\u7d50\u8ad6<\/strong><\/h2>\n<p>\u56db\u7dad\u7121\u6bd2\u7642\u6cd5\u6574\u5408\u4e86\u89e3\u6c7a\u764c\u75c7\u8907\u96dc\u6027\u7684\u5c16\u7aef\u7b56\u7565\uff0c\u6bcf\u7a2e\u65b9\u6cd5\u90fd\u5f97\u5230\u65b0\u8208\u7814\u7a76\u7684\u652f\u6301\u3002\u7136\u800c\uff0c\u816b\u7624\u7570\u8cea\u6027\u3001\u81e8\u5e8a\u9a57\u8b49\u548c\u53ef\u8fd1\u6027\u7b49\u6311\u6230\u9700\u8981\u4e0d\u65b7\u63a2\u7d22\u3002\u5efa\u8b70\u7684\u53e3\u865f\u548c\u53e3\u865f\u65e8\u5728\u9ad4\u73fe\u8a72\u7642\u6cd5\u7684\u627f\u8afe\uff0c\u4e26\u5f15\u767c\u5c0d\u5176\u6539\u8b8a\u764c\u75c7\u6cbb\u7642\u6f5b\u529b\u7684\u9032\u4e00\u6b65\u8a0e\u8ad6\u3002<\/p>\n<h2>\u4e3b\u8981\u5f15\u6587<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a><\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a><\/li>\n<li><a href=\"https:\/\/www.lifespringcancer.com\/metronomic-chemotherapy\/\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a><\/li>\n<\/ul>\n<hr>\n<div class=\"ac-blog-cta\">\n<h2>\u9700\u8981\u5354\u52a9\u4e86\u89e3\u6cbb\u7642\u9078\u64c7\uff1f<\/h2>\n<p>\u6211\u5011\u7684\u60a3\u8005\u670d\u52d9\u5718\u968a\u53ef\u4ee5\u5e6b\u52a9\u60a8\u6e96\u5099\u5831\u544a\u4e26\u5b89\u6392\u9069\u7576\u7684\u5c08\u5bb6\u8aee\u8a62\u3002\u672c\u6587\u662f\u4e00\u822c\u8a0a\u606f\uff0c\u800c\u4e0d\u662f\u8a3a\u65b7\u3002<\/p>\n<p><a href=\"\/zh-hk\/appointment\/\">\u9810\u7d04\u8aee\u8a62<\/a> &nbsp;|&nbsp; <a href=\"\/zh-hk\/cancer\/\">\u63a2\u7d22\u6240\u6709\u764c\u75c7\u985e\u578b<\/a><\/p>\n<\/div>\n<p class=\"ac-blog-disclaimer\"><em>\u91ab\u7642\u514d\u8cac\u8072\u660e\uff1a\u672c\u6587\u50c5\u7528\u65bc\u4e00\u822c\u6559\u80b2\uff0c\u4e0d\u80fd\u53d6\u4ee3\u5408\u683c\u81e8\u5e8a\u91ab\u751f\u7684\u5efa\u8b70\u3002\u6cbb\u7642\u6c7a\u5b9a\u61c9\u57fa\u65bc\u500b\u4eba\u7684\u8a3a\u65b7\u3001\u5206\u671f\u3001\u75c5\u7406\u548c\u6574\u9ad4\u5065\u5eb7\u72c0\u6cc1\u3002\u5982\u679c\u60a8\u767c\u73fe\u6301\u7e8c\u6216\u4ee4\u4eba\u64d4\u6182\u7684\u75c7\u72c0\uff0c\u8acb\u5c0b\u6c42\u91ab\u7642\u8a55\u4f30\u3002<\/em><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Diffuse Intrinsic Pontine Glioma (DIPG) is a highly aggressive, malignant brainstem tumor predominantly affecting children aged 5\u201310 years.<\/p>","protected":false},"featured_media":234,"menu_order":30,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-352","cancer_type","type-cancer_type","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/all-cancers.com\/zh-hk\/wp-json\/wp\/v2\/cancer_type\/352","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/all-cancers.com\/zh-hk\/wp-json\/wp\/v2\/cancer_type"}],"about":[{"href":"https:\/\/all-cancers.com\/zh-hk\/wp-json\/wp\/v2\/types\/cancer_type"}],"version-history":[{"count":1,"href":"https:\/\/all-cancers.com\/zh-hk\/wp-json\/wp\/v2\/cancer_type\/352\/revisions"}],"predecessor-version":[{"id":492,"href":"https:\/\/all-cancers.com\/zh-hk\/wp-json\/wp\/v2\/cancer_type\/352\/revisions\/492"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/all-cancers.com\/zh-hk\/wp-json\/wp\/v2\/media\/234"}],"wp:attachment":[{"href":"https:\/\/all-cancers.com\/zh-hk\/wp-json\/wp\/v2\/media?parent=352"}],"curies":[{"name":"\u53ef\u6fd5\u6027\u7c89\u5291","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}