{"id":368,"date":"2026-07-20T09:00:00","date_gmt":"2026-07-20T09:00:00","guid":{"rendered":"https:\/\/all-cancers.com\/cancer\/multiple-myeloma-plasma-cell-myeloma-cancer\/"},"modified":"2026-10-29T13:38:06","modified_gmt":"2026-10-29T13:38:06","slug":"multiple-myeloma-plasma-cell-myeloma-cancer","status":"publish","type":"cancer_type","link":"https:\/\/all-cancers.com\/zh-hk\/cancer\/multiple-myeloma-plasma-cell-myeloma-cancer\/","title":{"rendered":"\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09"},"content":{"rendered":"<div class=\"ac-blog-article\">\n<p class=\"ac-blog-lead\"><strong>\u8981\u4e86\u89e3\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09\u9996\u5148\u8981\u8a8d\u8b58\u5176\u7368\u7279\u7684\u751f\u7269\u5b78\u6027\u8cea\u3002\u9019\u7a2e\u764c\u75c7\u8d77\u6e90\u65bc\u6f3f\u7d30\u80de\uff0d\u8ca0\u8cac\u7522\u751f\u6297\u611f\u67d3\u6297\u9ad4\u7684\u767d\u8840\u7403\u3002\u5728\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09\u4e2d\uff0c\u764c\u6027\u6f3f\u7d30\u80de\u5728\u9aa8\u9ad3\u4e2d\u904e\u5ea6\u7a4d\u805a\uff0c\u5e79\u64fe\u5065\u5eb7\u7684\u8840\u7403\u751f\u6210\u4e26\u9020\u6210\u8a31\u591a\u5065\u5eb7\u5a01\u8105\u3002<\/strong><\/p>\n<nav class=\"ac-blog-toc\" aria-label=\"\u672c\u6587\u5c0e\u89bd\">\n<p><strong>\u672c\u6587\u5c0e\u89bd<\/strong><\/p>\n<ul>\n<li><a href=\"#what-is-multiple-myeloma-plasma-cell-myeloma\">\u4ec0\u9ebc\u662f\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09\uff1f<\/a><\/li>\n<li><a href=\"#causes-and-risk-factors-of-multiple-myeloma-plasma-cell-myeloma\">\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09\u7684\u75c5\u56e0\u548c\u5371\u96aa\u56e0\u5b50<\/a><\/li>\n<li><a href=\"#symptoms-of-multiple-myeloma-plasma-cell-myeloma\">\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09\u7684\u75c7\u72c0<\/a><\/li>\n<li><a href=\"#stages-of-multiple-myeloma-plasma-cell-myeloma-and-survival-rates\">\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09\u7684\u5206\u671f\u548c\u5b58\u6d3b\u7387<\/a><\/li>\n<li><a href=\"#limitations-of-traditional-therapies-for-multiple-myeloma-plasma-cell-myeloma\">\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09\u50b3\u7d71\u7642\u6cd5\u7684\u5c40\u9650\u6027<\/a><\/li>\n<\/ul>\n<\/nav>\n<h2 id=\"what-is-multiple-myeloma-plasma-cell-myeloma\">\u4ec0\u9ebc\u662f <strong>\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09<\/strong>?<\/h2>\n<p>\u9019\u4e9b\u60e1\u6027\u7d30\u80de\u8868\u73fe\u51fa\u7368\u7279\u7684\u4ee3\u8b1d\u6a21\u5f0f\uff0c\u7a31\u70ba\u74e6\u723e\u5821\u6548\u61c9\uff0c\u5176\u4e2d\u764c\u7d30\u80de\u6d88\u8017\u8461\u8404\u7cd6\u7684\u901f\u5ea6\u5927\u7d04\u662f\u6b63\u5e38\u7d30\u80de\u7684 200 \u500d\u3002\u5c0d\u8461\u8404\u7cd6\u7684\u5982\u6b64\u5f37\u70c8\u7684\u9700\u6c42\u4f7f\u5f97\u816b\u7624\u7d30\u80de\u80fd\u5920\u7e41\u6b96\u548c\u751f\u5b58\uff0c\u5f9e\u800c\u8fc5\u901f\u8017\u76e1\u5065\u5eb7\u7d30\u80de\u529f\u80fd\u6240\u5fc5\u9700\u7684\u71df\u990a\u7269\u8cea\u3002<\/p>\n<h3 id=\"global-and-regional-prevalence\">\u5168\u7403\u548c\u5340\u57df\u76db\u884c\u7387<\/h3>\n<p>\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09\u662f\u5168\u7403\u7b2c\u4e8c\u5e38\u898b\u7684\u8840\u6db2\u60e1\u6027\u816b\u7624\uff0c\u7d04\u4f54\u5168\u7403\u6240\u6709\u764c\u75c7\u75c5\u4f8b\u7684 1.2%\uff0c\u6839\u64da\u4e16\u754c\u885b\u751f\u7d44\u7e54 2024 \u5e74\u7684\u6578\u64da\uff0c\u6bcf\u5e74\u5f71\u97ff\u7d04 18 \u842c\u4eba\u3002\u5176\u76db\u884c\u7387\u96a8\u8457\u5e74\u9f61\u7684\u589e\u9577\u800c\u589e\u52a0\uff0c\u4e3b\u8981\u5f71\u97ff 65 \u6b72\u4ee5\u4e0a\u7684\u6210\u5e74\u4eba\uff0c\u5c24\u5176\u662f\u7537\u6027\u3002\u5728\u9999\u6e2f\uff0c\u5b83\u4f4d\u5c45\u5341\u5927\u8840\u6db2\u764c\u75c7\u4e4b\u5217\uff0c\u6bcf\u5e74\u7d04\u6709400\u4f8b\u65b0\u767c\u75c5\u4f8b\u3002<\/p>\n<ul>\n<li>\u5168\u7403\u6bcf\u5e74\u767c\u751f\u7387\uff1a~180,000\uff08\u4e16\u754c\u885b\u751f\u7d44\u7e54\uff0c2024 \u5e74\uff09<\/li>\n<li>\u4e3b\u8981\u5e74\u9f61\u5c64\uff1a65\u6b72\u4ee5\u4e0a<\/li>\n<li>\u6027\u5225\u5206\u4f48\uff1a\u7537\u6027\u7565\u9ad8<\/li>\n<li>\u9999\u6e2f\u6bcf\u5e74\u65b0\u589e\u78ba\u8a3a\u7d04 400 \u4f8b<\/li>\n<\/ul>\n<h3 id=\"impact-on-quality-of-life\">\u5c0d\u751f\u6d3b\u54c1\u8cea\u7684\u5f71\u97ff<\/h3>\n<p>\u5f9e\u8eab\u9ad4\u548c\u60c5\u7dd2\u4e0a\u4f86\u8aaa\uff0c\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u90fd\u6703\u4f7f\u4eba\u6975\u5ea6\u865b\u5f31\u3002\u5e38\u898b\u75c7\u72c0\u5305\u62ec\u9aa8\u75db\uff08\u5c24\u5176\u662f\u810a\u690e\u548c\u808b\u9aa8\uff09\u3001\u904e\u5ea6\u75b2\u52de\u3001\u8ca7\u8840\u3001\u514d\u75ab\u529b\u4e0b\u964d\u5c0e\u81f4\u983b\u7e41\u611f\u67d3\u3001\u814e\u529f\u80fd\u640d\u50b7\u548c\u75c5\u7406\u6027\u9aa8\u6298\u3002<\/p>\n<ul>\n<li>\u9aa8\u75db\u548c\u9aa8\u6298\u5f71\u97ff\u6d3b\u52d5\u80fd\u529b<\/li>\n<li>\u6162\u6027\u75b2\u52de\u548c\u65e5\u5e38\u6d3b\u52d5\u8010\u53d7\u529b\u964d\u4f4e<\/li>\n<li>\u514d\u75ab\u6291\u5236\u5c0e\u81f4\u53cd\u8986\u611f\u67d3<\/li>\n<li>\u814e\u529f\u80fd\u969c\u7919\u56b4\u91cd\u6642\u5c0e\u81f4\u900f\u6790\u4f9d\u8cf4<\/li>\n<\/ul>\n<p>\u5728\u60c5\u611f\u4e0a\uff0c\u9019\u500b\u8a3a\u65b7\u5e36\u4f86\u4e86\u5de8\u5927\u7684\u5fc3\u7406\u56f0\u64fe\uff0c\u5305\u62ec\u7126\u616e\u548c\u6182\u9b31\u3002\u65e9\u671f\u4ecb\u5165\u548c\u5275\u65b0\u6cbb\u7642\u7b56\u7565\u53ef\u986f\u8457\u6539\u5584\u751f\u6d3b\u54c1\u8cea\u548c\u5b58\u6d3b\u7d50\u679c\u3002<\/p>\n<p>\u4e86\u89e3\u6709\u95dc\u764c\u75c7\u751f\u7269\u5b78\u548c\u8a3a\u65b7\u7684\u66f4\u591a\u4fe1\u606f <a href=\"\/zh-hk\/treatment-cancer\/\">\u764c\u75c7\u751f\u7269\u5b78<\/a> \u548c <a href=\"\/zh-hk\/our-hospital\/\">\u8a3a\u65b7<\/a> \u9801\u3002<\/p>\n<h2 id=\"causes-and-risk-factors-of-multiple-myeloma-plasma-cell-myeloma\">\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09\u7684\u75c5\u56e0\u548c\u5371\u96aa\u56e0\u5b50<\/h2>\n<p>\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09\u7684\u78ba\u5207\u75c5\u56e0\u4ecd\u7136\u90e8\u5206\u96e3\u4ee5\u6349\u6478\uff0c\u4f46\u7814\u7a76\u78ba\u5b9a\u4e86\u986f\u8457\u589e\u52a0\u6613\u611f\u6027\u7684\u95dc\u9375\u907a\u50b3\u3001\u74b0\u5883\u548c\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\u3002<\/p>\n<h3 id=\"genetic-predisposition\">\u907a\u50b3\u50be\u5411<\/h3>\n<p>\u67d3\u8272\u9ad4\u7f3a\u5931\u3001\u6613\u4f4d\u548c\u7279\u5b9a\u7a81\u8b8a\uff08\u4f8b\u5982 TP53 \u6216 MYC \u57fa\u56e0\u7a81\u8b8a\uff09\u7b49\u907a\u50b3\u7570\u5e38\u53ef\u80fd\u4f7f\u500b\u9ad4\u6613\u60a3\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u3002\u8207\u4e00\u822c\u4eba\u7fa4\u76f8\u6bd4\uff0c\u53d7\u5f71\u97ff\u60a3\u8005\u7684\u5bb6\u5ead\u6210\u54e1\u7684\u98a8\u96aa\u589e\u52a0\u7d04 2-3 \u500d\u3002<\/p>\n<ul>\n<li>\u67d3\u8272\u9ad4\u7570\u5e38\uff08\u4f8b\u5982 13q \u7f3a\u5931\u300117p \u7f3a\u5931\uff09<\/li>\n<li>TP53\u3001MYC \u548c\u5176\u4ed6\u57fa\u56e0\u5c64\u7d1a\u7a81\u8b8a<\/li>\n<li>\u5bb6\u65cf\u53f2\u589e\u52a0\u6613\u611f\u6027<\/li>\n<\/ul>\n<h3 id=\"environmental-and-occupational-factors\">\u74b0\u5883\u548c\u8077\u696d\u56e0\u7d20<\/h3>\n<p>\u66b4\u9732\u65bc\u8f3b\u5c04\u3001\u82ef\u7b49\u5316\u5b78\u7269\u8cea\u3001\u6bba\u87f2\u5291\u548c\u91cd\u5de5\u696d\u6c61\u67d3\u5df2\u8b49\u660e\u8207\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7684\u98a8\u96aa\u589e\u52a0\u6709\u95dc\u3002\u7279\u5b9a\u8077\u696d\u7fa4\u9ad4\uff0c\u5305\u62ec\u8fb2\u696d\u5de5\u4eba\u548c\u5316\u5b78\u5de5\u696d\u54e1\u5de5\uff0c\u767c\u75c5\u7387\u8f03\u9ad8\u3002<\/p>\n<ul>\n<li>\u8f3b\u5c04\u66dd\u9732<\/li>\n<li>\u82ef\u548c\u5316\u5b78\u6bd2\u7d20\u66b4\u9732<\/li>\n<li>\u8fb2\u696d\u8fb2\u85e5\u63a5\u89f8<\/li>\n<\/ul>\n<h3 id=\"lifestyle-risk-factors\">\u751f\u6d3b\u65b9\u5f0f\u98a8\u96aa\u56e0\u7d20<\/h3>\n<p>\u80a5\u80d6\uff0c\u7279\u5225\u662f\u8179\u90e8\u80a5\u80d6\uff0c\u53ef\u80fd\u6703\u589e\u52a0\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\u7684\u98a8\u96aa\u3002\u591a\u9918\u7684\u8102\u80aa\u7d44\u7e54\u6703\u5206\u6ccc\u767c\u708e\u7d30\u80de\u56e0\u5b50\uff0c\u5275\u9020\u4fc3\u816b\u7624\u5fae\u74b0\u5883\u3002\u5438\u83f8\u7fd2\u6163\u96d6\u7136\u4e0d\u662f\u76f4\u63a5\u539f\u56e0\uff0c\u4f46\u6703\u524a\u5f31\u6574\u9ad4\u514d\u75ab\u53cd\u61c9\uff0c\u52a0\u5287\u4eba\u5011\u7f79\u60a3\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7b49\u56b4\u91cd\u75be\u75c5\u7684\u98a8\u96aa\u3002<\/p>\n<ul>\n<li>\u80a5\u80d6\u548c\u6162\u6027\u708e\u75c7<\/li>\n<li>\u9577\u671f\u5438\u83f8\u5c0e\u81f4\u514d\u75ab\u529f\u80fd\u4e0b\u964d<\/li>\n<li>\u4e0d\u5065\u5eb7\u7684\u98f2\u98df\u7f3a\u4e4f\u7d30\u80de\u5065\u5eb7\u6240\u5fc5\u9700\u7684\u6297\u6c27\u5316\u5291<\/li>\n<\/ul>\n<h3 id=\"metabolic-vulnerabilities-of-cancer-cells\">\u764c\u7d30\u80de\u7684\u4ee3\u8b1d\u8106\u5f31\u6027<\/h3>\n<p>\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u764c\u7d30\u80de\u8868\u73fe\u51fa\u7368\u7279\u7684\u4ee3\u8b1d\u4f9d\u8cf4\u6027\uff0c\u7279\u5225\u662f\u5c0d\u8461\u8404\u7cd6\uff08\u74e6\u723e\u5821\u6548\u61c9\uff09\u548c\u9ea9\u91af\u80fa\u9178\u4ee3\u8b1d\u7684\u4f9d\u8cf4\u6027\u589e\u52a0\u3002\u5927\u7d04 50% \u7684\u764c\u7d30\u80de\u56b4\u91cd\u4f9d\u8cf4\u9ea9\u91af\u80fa\u9178\u6d88\u8017\u4f86\u5408\u6210\u6838\u82f7\u9178\uff0c\u9019\u662f\u5feb\u901f\u589e\u6b96\u6240\u5fc5\u9700\u7684\u3002\u9019\u7a2e\u4ee3\u8b1d\u5f31\u9ede\u5728\u4ee3\u8b1d\u816b\u7624\u5b78\u7814\u7a76\u7684\u6df1\u5165\u7814\u7a76\u4e2d\u63d0\u4f9b\u4e86\u5275\u65b0\u7684\u6cbb\u7642\u6a19\u9776\u3002<\/p>\n<ul>\n<li>\u9ad8\u7cd6\u89e3\u6d3b\u6027\uff08\u74e6\u723e\u5821\u6548\u61c9\uff09<\/li>\n<li>\u6838\u82f7\u9178\u5408\u6210\u4f9d\u8cf4\u9ea9\u91af\u80fa\u9178\uff0850% \u764c\u7d30\u80de\uff09<\/li>\n<li>HK\u4ee3\u8b1d\u7642\u6cd5\u7b49\u5275\u65b0\u7642\u6cd5\u7684\u6f5b\u5728\u76ee\u6a19<\/li>\n<\/ul>\n<p>\u5728\u9999\u6e2f\u548c\u6574\u500b\u4e9e\u6d32\uff0c\u809d\u708e\u75c5\u6bd2\u60a3\u75c5\u7387\u8f03\u9ad8\u7b49\u7368\u7279\u56e0\u7d20\u9593\u63a5\u5c0e\u81f4\u6574\u9ad4\u514d\u75ab\u529f\u80fd\u969c\u7919\uff0c\u5f9e\u800c\u986f\u8457\u5f71\u97ff\u5340\u57df\u764c\u75c7\u683c\u5c40\u3002<\/p>\n<h3 id=\"encouraging-early-screening-and-prevention\">\u9f13\u52f5\u65e9\u671f\u7be9\u6aa2\u548c\u9810\u9632<\/h3>\n<p>\u900f\u904e\u5b9a\u671f\u7be9\u6aa2\u9032\u884c\u65e9\u671f\u767c\u73fe\u548c\u4e86\u89e3\u500b\u4eba\u5371\u96aa\u56e0\u5b50\u662f\u9810\u9632\u548c\u53ca\u6642\u958b\u59cb\u6cbb\u7642\u7684\u91cd\u8981\u63aa\u65bd\u3002\u4e0d\u53ef\u5426\u8a8d\u7684\u662f\uff0c\u610f\u8b58\u548c\u884c\u52d5\u53ef\u4ee5\u6539\u5584\u9810\u5f8c\u4e26\u63d0\u9ad8\u6cbb\u7642\u5f8c\u7684\u751f\u6d3b\u54c1\u8cea\u3002<\/p>\n<ul>\n<li>\u5e38\u898f\u8840\u6db2\u6aa2\u67e5\u548c\u5e74\u5ea6\u5065\u5eb7\u6aa2\u67e5<\/li>\n<li>\u5c0d\u75c7\u72c0\u6307\u6a19\u7684\u8a8d\u8b58<\/li>\n<li>\u5c0d\u9ad8\u98a8\u96aa\u5bb6\u5ead\u6210\u54e1\u9032\u884c\u65e9\u671f\u57fa\u56e0\u7be9\u6aa2<\/li>\n<\/ul>\n<p>\u63a2\u7d22\u6211\u5011\u7ba1\u7406\u548c\u514b\u670d\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7684\u7d9c\u5408\u7642\u6cd5\u3002 <a href=\"\/zh-hk\/treatment-cancer\/\">\u4e86\u89e3 4D \u7642\u6cd5\u5982\u4f55\u6539\u8b8a\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09\u6cbb\u7642<\/a>.<\/p>\n<h2 id=\"symptoms-of-multiple-myeloma-plasma-cell-myeloma\">\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09\u7684\u75c7\u72c0<\/h2>\n<p>\u8a8d\u8b58 <strong>\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09<\/strong> \u65e9\u671f\u75c7\u72c0\u5c0d\u65bc\u6539\u5584\u6cbb\u7642\u7d50\u679c\u548c\u6574\u9ad4\u9810\u5f8c\u81f3\u95dc\u91cd\u8981\u3002\u53ef\u4ee5\u7406\u89e3\u7684\u662f\uff0c\u6839\u64da\u75be\u75c5\u7684\u9032\u5c55\u968e\u6bb5\uff0c\u75c7\u72c0\u53ef\u80fd\u6703\u5927\u4e0d\u76f8\u540c\u3002\u4ee5\u4e0b\u662f\u9019\u7a2e\u60e1\u6027\u816b\u7624\u7684\u5e38\u898b\u548c\u7368\u7279\u8868\u73fe\u7684\u5168\u9762\u7d30\u5206\uff1a<\/p>\n<h3 id=\"common-initial-symptoms-early-signs-of-multiple-myeloma\">\u5e38\u898b\u7684\u521d\u59cb\u75c7\u72c0\uff08\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7684\u65e9\u671f\u75c7\u72c0\uff09<\/h3>\n<ul>\n<li>\u4e0d\u660e\u539f\u56e0\u7684\u75b2\u52de\u548c\u6301\u7e8c\u7684\u865b\u5f31<\/li>\n<li>\u9aa8\u75db\uff0c\u901a\u5e38\u767c\u751f\u5728\u810a\u690e\u6216\u808b\u9aa8\uff0c\u904b\u52d5\u6642\u6703\u52a0\u5287<\/li>\n<li>\u9aa8\u9ad3\u6d78\u6f64\u5f15\u8d77\u8ca7\u8840\uff0c\u5c0e\u81f4\u76ae\u819a\u84bc\u767d\u3001\u982d\u6688<\/li>\n<li>\u514d\u75ab\u529f\u80fd\u53d7\u640d\u5c0e\u81f4\u983b\u7e41\u611f\u67d3<\/li>\n<li>\u4e0d\u660e\u539f\u56e0\u7684\u9ad4\u91cd\u6e1b\u8f15\u548c\u98df\u617e\u4e0b\u964d<\/li>\n<\/ul>\n<h3 id=\"symptoms-related-to-advanced-stages-of-multiple-myeloma\">\u8207\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u665a\u671f\u76f8\u95dc\u7684\u75c7\u72c0<\/h3>\n<ul>\n<li>\u7531\u764c\u75c7\u76f8\u95dc\u9aa8\u8cea\u758f\u9b06\u75c7\u5f15\u8d77\u7684\u7121\u91cd\u5927\u5275\u50b7\u7684\u9aa8\u6298<\/li>\n<li>\u904e\u5ea6\u53e3\u6e34\u548c\u983b\u5c3f\uff0c\u8868\u793a\u9ad8\u9223\u8840\u75c7\uff08\u9ad8\u8840\u9223\uff09<\/li>\n<li>\u814e\u529f\u80fd\u969c\u7919\u5c0e\u81f4\u817f\u90e8\u6216\u8173\u8e1d\u816b\u8139<\/li>\n<li>\u816b\u7624\u58d3\u8feb\u810a\u9ad3\u5c0e\u81f4\u7684\u795e\u7d93\u7cfb\u7d71\u75c7\u72c0\uff0c\u5305\u62ec\u56db\u80a2\u9ebb\u6728\u6216\u7121\u529b<\/li>\n<li>\u8840\u6e05\u86cb\u767d\u6c34\u5e73\u5347\u9ad8\u5f15\u8d77\u7684\u56b4\u91cd\u9ad8\u9ecf\u5ea6\u75c7\u5019\u7fa4\u5c0e\u81f4\u8996\u89ba\u969c\u7919\u3001\u610f\u8b58\u6a21\u7cca\u6216\u982d\u75db<\/li>\n<\/ul>\n<p>\u9019\u4e9b\u75c7\u72c0\u53cd\u6620\u4e86\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7684\u751f\u7269\u6d3b\u6027\u548c\u8907\u96dc\u6027\uff0c\u7279\u5225\u662f\u7531\u65bc\u9aa8\u9ad3\u4e2d\u6f3f\u7d30\u80de\u589e\u6b96\u3001\u7570\u5e38\u86cb\u767d\u8cea\u904e\u5ea6\u5206\u6ccc\u4ee5\u53ca\u9ad8\u9223\u8840\u75c7\u7b49\u4ee3\u8b1d\u7d0a\u4e82\u6240\u81f4\u3002\u89c0\u5bdf\u75c7\u72c0\u5f8c\u53ca\u6642\u5c31\u91ab\u53ef\u986f\u8457\u63d0\u9ad8\u8a3a\u65b7\u6e96\u78ba\u6027\u548c\u5b58\u6d3b\u524d\u666f\u3002<\/p>\n<h2 id=\"stages-of-multiple-myeloma-plasma-cell-myeloma-and-survival-rates\">\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09\u7684\u5206\u671f\u548c\u5b58\u6d3b\u7387<\/h2>\n<p>\u6e96\u78ba\u7684\u5206\u671f <strong>\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09<\/strong> \u5c0d\u65bc\u78ba\u5b9a\u60a3\u8005\u7684\u6cbb\u7642\u7b56\u7565\u3001\u9810\u5f8c\u548c\u5b58\u6d3b\u9810\u671f\u81f3\u95dc\u91cd\u8981\u3002\u5e38\u7528\u7684\u5206\u671f\u7cfb\u7d71\u662f\u4fee\u8a02\u7248\u570b\u969b\u5206\u671f\u7cfb\u7d71\uff08R-ISS\uff09\uff0c\u5176\u4e2d\u7d50\u5408\u4e86\u8840\u6e05\u53c3\u6578\u548c\u907a\u50b3\u5716\u8b5c\u3002\u4ee5\u4e0b\u662f\u8207\u9999\u6e2f\u548c\u4e9e\u6d32\u60a3\u8005\u7279\u5225\u76f8\u95dc\u7684\u6cbb\u7642\u9078\u64c7\u548c\u751f\u5b58\u9810\u671f\u76f8\u95dc\u7684\u63cf\u8ff0\uff0c\u91cd\u9ede\u4ecb\u7d39\u4e86\u5340\u57df\u89c0\u5bdf\u7d50\u679c\u3002<\/p>\n<h3 id=\"stage-1-early-stage-multiple-myeloma\">\u7b2c\u4e00\u968e\u6bb5 \u2013 \u65e9\u671f\u591a\u767c\u6027\u9aa8\u9ad3\u7624<\/h3>\n<p>\u5728\u7b2c\u4e00\u968e\u6bb5\uff0c\u60a3\u8005\u901a\u5e38\u8868\u73fe\u51fa\u8f03\u5c11\u7684\u81e8\u5e8a\u5f71\u97ff\u548c\u8f03\u5c0f\u7684\u751f\u7269\u7834\u58de\uff1a<\/p>\n<ul>\n<li>\u9aa8\u9ad3\u5167\u6f3f\u7d30\u80de\u589e\u751f\u76f8\u5c0d\u8f03\u4f4e\uff08&lt;20%\uff09<\/li>\n<li>\u7121\u660e\u986f\u9aa8\u75c5\u8b8a\u4e14\u75c7\u72c0\u8f15\u5fae<\/li>\n<li>\u6b63\u5e38\u7684\u9223\u6c34\u5e73\u548c\u814e\u529f\u80fd<\/li>\n<li>\u8ca7\u8840\u6216\u8f15\u5ea6\u8ca7\u8840<\/li>\n<\/ul>\n<p>\u6cbb\u7642\u901a\u5e38\u5305\u62ec\uff1a<\/p>\n<ul>\n<li>\u5982\u679c\u7121\u75c7\u72c0\uff0c\u5247\u6700\u521d\u63a1\u53d6\u89c0\u5bdf\u7b56\u7565\u6216\u300c\u89c0\u5bdf\u7b49\u5f85\u300d\uff08\u5192\u7159\u6027\u9aa8\u9ad3\u7624\uff09<\/li>\n<li>\u5316\u7642\u65b9\u6848\uff08\u4f8b\u5982 VRd \u65b9\u6848\uff1a\u787c\u66ff\u4f50\u7c73\u3001\u4f86\u90a3\u5ea6\u80fa\u3001\u5730\u585e\u7c73\u677e\uff09<\/li>\n<li>\u9069\u5408\u5019\u9078\u4eba\u7684\u6f5b\u5728\u5e79\u7d30\u80de\u79fb\u690d<\/li>\n<\/ul>\n<p>\u5b58\u6d3b\u7387\uff1a\u6839\u64da\u9999\u6e2f\u764c\u75c7\u767b\u8a18\u86552024\u5e74\u7684\u6700\u65b0\u7d71\u8a08\u6578\u64da\uff0c1\u671f\u60a3\u8005\u901a\u5e38\u9810\u5f8c\u826f\u597d\uff0c5\u5e74\u5b58\u6d3b\u7387\u8d85\u904e80%\u3002<\/p>\n<h3 id=\"stage-2-intermediate-multiple-myeloma\">\u7b2c 2 \u671f \u2013 \u4e2d\u5ea6\u591a\u767c\u6027\u9aa8\u9ad3\u7624<\/h3>\n<p>\u7b2c\u4e8c\u968e\u6bb5\u6a19\u8a8c\u8457\u4e2d\u9593\u9032\u5c55\uff0c\u6700\u5148\u9032\u7684\u8a3a\u65b7\u986f\u793a\uff1a<\/p>\n<ul>\n<li>\u9aa8\u9ad3\u5207\u7247\u6aa2\u67e5\u4e2d\u6f3f\u7d30\u80de\u8ca0\u8377\u589e\u52a0\uff0820-50%\uff09<\/li>\n<li>\u900f\u904e\u5f71\u50cf\u5b78\uff08PET\u3001MRI\uff09\u767c\u73fe\u5b58\u5728\u591a\u500b\u8f15\u5fae\u9aa8\u9abc\u75c5\u8b8a<\/li>\n<li>\u4e2d\u5ea6\u8ca7\u8840\uff0c\u814e\u529f\u80fd\u7d30\u5fae\u8b8a\u5316<\/li>\n<li>\u7121\u56b4\u91cd\u9ad8\u8840\u9223\u75c7<\/li>\n<\/ul>\n<p>\u7b2c\u4e8c\u968e\u6bb5\u6cbb\u7642\u901a\u5e38\u6d89\u53ca\u5f37\u5316\u6cbb\u7642\uff0c\u5305\u62ec\uff1a<\/p>\n<ul>\n<li>\u5408\u4f75\u5316\u7642\u548c\u6a19\u9776\u6cbb\u7642\uff08\u4f8b\u5982 IMiD\uff1a\u4f86\u90a3\u5ea6\u80fa\uff09<\/li>\n<li>\u9ad8\u5291\u91cf\u5316\u7642\u5f8c\u9032\u884c\u81ea\u9ad4\u5e79\u7d30\u80de\u79fb\u690d\uff0c\u88ab\u8a8d\u70ba\u662f\u9999\u6e2f\u548c\u4e9e\u6d32\u5730\u5340\u7b26\u5408\u689d\u4ef6\u7684\u60a3\u8005\u7684\u6a19\u6e96\u8b77\u7406<\/li>\n<li>\u5148\u9032\u7642\u6cd5\uff0c\u5305\u62ec\u6297 CD38 \u55ae\u682a\u6297\u9ad4\uff08\u4f8b\u5982 Daratumumab\uff09\uff0c\u53ef\u986f\u8457\u63d0\u9ad8\u6cbb\u7642\u6548\u679c<\/li>\n<\/ul>\n<p>\u5b58\u6d3b\u7387\uff1a\u6191\u85c9\u5148\u9032\u7684\u6cbb\u7642\u65b9\u6cd5\u548c\u65e9\u671f\u767c\u73fe\uff0c\u9999\u6e2f 2 \u671f\u60a3\u8005\u7684 5 \u5e74\u5b58\u6d3b\u7387\u5728 65% \u81f3 75% \u4e4b\u9593\u3002<\/p>\n<h3 id=\"stage-3-advanced-multiple-myeloma\">\u7b2c\u4e09\u968e\u6bb5 \u2013 \u665a\u671f\u591a\u767c\u6027\u9aa8\u9ad3\u7624<\/h3>\n<p>\u6b64\u968e\u6bb5\u7531\u660e\u986f\u7684\u81e8\u5e8a\u8868\u73fe\u548c\u91cd\u8981\u7684\u5be6\u9a57\u5ba4\u6aa2\u67e5\u7d50\u679c\u4f86\u63cf\u8ff0\uff1a<\/p>\n<ul>\n<li>\u9aa8\u9ad3\u4e2d\u5ee3\u6cdb\u7684\u6f3f\u7d30\u80de\u6d78\u6f64\uff08&gt;50%\uff09<\/li>\n<li>\u591a\u767c\u6027\u7834\u58de\u6027\u9aa8\u75c5\u8b8a\u3001\u75c5\u7406\u6027\u9aa8\u6298<\/li>\n<li>\u660e\u986f\u8ca7\u8840\u3001\u8840\u6e05\u9223\u6fc3\u5ea6\u5347\u9ad8\u3001\u660e\u986f\u814e\u529f\u80fd\u640d\u5bb3<\/li>\n<li>\u8840\u6e05\u03b22\u5fae\u7403\u86cb\u767d\u660e\u986f\u5347\u9ad8<\/li>\n<\/ul>\n<p>\u6cbb\u7642\u5305\u62ec\u7a4d\u6975\u7642\u6cd5\uff1a<\/p>\n<ul>\n<li>\u591a\u7dda\u5316\u7642\u548c\u514d\u75ab\u6cbb\u7642<\/li>\n<li>\u91dd\u5c0d\u75bc\u75db\u6027\u75c5\u7076\u6216\u810a\u9ad3\u53d7\u58d3\u7684\u6a19\u9776\u653e\u5c04\u6cbb\u7642<\/li>\n<li>\u7d9c\u5408\u652f\u6301\u6027\u8b77\u7406\uff08\u7528\u65bc\u9aa8\u9abc\u4fdd\u8b77\u7684\u96d9\u78f7\u9178\u9e7d\uff09<\/li>\n<li>\u65e8\u5728\u5229\u7528\u7279\u5b9a\u8106\u5f31\u6027\u7684\u65b0\u578b\u4ee3\u8b1d\u7642\u6cd5\uff0c\u4f8b\u5982\u9ea9\u91af\u80fa\u9178\u4f9d\u8cf4\u6027\u9014\u5f91\u548c\u74e6\u723e\u5821\u6548\u61c9\u7ba1\u7406<\/li>\n<\/ul>\n<p>\u5b58\u6d3b\u7387\uff1a\u4e9e\u592a\u816b\u7624\u5b78\u6703\u7684\u5340\u57df\u6578\u64da\u8868\u660e\uff0c\u63a1\u7528\u9818\u5148\u816b\u7624\u4e2d\u5fc3\u63d0\u4f9b\u7684\u7d9c\u5408\u548c\u500b\u4eba\u5316\u7b56\u7565\u6cbb\u7642\u7684\u665a\u671f\u75c5\u4f8b\u5728\u8a3a\u65b7\u5f8c 5 \u5e74\u7684\u5b58\u6d3b\u7387\u7d04\u70ba 45%-55%\u3002<\/p>\n<h3 id=\"stage-4-metastatic-end-stage-multiple-myeloma\">\u7b2c\u56db\u968e\u6bb5 \u2013 \u8f49\u79fb\u6027\/\u672b\u671f\u591a\u767c\u6027\u9aa8\u9ad3\u7624<\/h3>\n<p>\u5118\u7ba1\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u6c92\u6709\u5178\u578b\u7684\u201c\u7b2c 4 \u671f\u201d\uff0c\u4f46\u8a72\u8853\u8a9e\u8c61\u5fb5\u6027\u5730\u9069\u7528\u65bc\u672b\u671f\u6216\u96e3\u6cbb\u6027\u75be\u75c5\uff1a<\/p>\n<ul>\n<li>\u5ee3\u6cdb\u7684\u9aa8\u9ad3\u6d78\u6f64\uff0c\u53ef\u80fd\u6709\u9ad3\u5916\u64f4\u6563<\/li>\n<li>\u56b4\u91cd\u75c7\u72c0\u6027\u9ad8\u8840\u9223\u3001\u56b4\u91cd\u9aa8\u640d\u50b7\u3001\u56b4\u91cd\u814e\u8870\u7aed<\/li>\n<li>\u660e\u986f\u7684\u5168\u8eab\u75c7\u72c0\u8ca0\u64d4\u5c0e\u81f4\u5371\u53ca\u751f\u547d\u7684\u4f75\u767c\u75c7<\/li>\n<\/ul>\n<p>\u6cbb\u7642\u65b9\u6848\u5305\u62ec\uff1a<\/p>\n<ul>\n<li>\u65e8\u5728\u63a7\u5236\u6162\u6027\u75c5\u7684\u7cbe\u6e96\u91ab\u5b78\u7642\u6cd5<\/li>\n<li>\u91dd\u5c0d\u96e3\u6cbb\u6027\u75be\u75c5\u7684\u5275\u65b0\u7642\u6cd5\uff0c\u4f8b\u5982 CAR-T \u7d30\u80de\u7642\u6cd5<\/li>\n<li>\u5f37\u5316\u652f\u6301\u8b77\u7406\uff0c\u5305\u62ec\u75bc\u75db\u63a7\u5236\u3001\u8840\u6db2\u5b78\u8aee\u8a62\u548c\u814e\u81df\u79d1\u652f\u6301<\/li>\n<\/ul>\n<p>\u5b58\u6d3b\u7387\uff1a\u5118\u7ba1\u9810\u5f8c\u5177\u6709\u6311\u6230\u6027\uff0cMD\u5b89\u5fb7\u68ee\u7b49\u8457\u540d\u6a5f\u69cb\u7684\u5021\u8b70\u4ee5\u53ca\u8207\u6df1\u5733\u524d\u6d77\u6cf0\u5eb7\u7684\u5408\u4f5c\u6240\u63a8\u51fa\u7684\u65b0\u82084D\u7642\u6cd5\u8d8a\u4f86\u8d8a\u52aa\u529b\u5730\u5c07\u7d42\u672b\u671f\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u8f49\u5316\u70ba\u53ef\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\uff0c\u89c0\u5bdf\u5230\u6700\u8fd1\u4e09\u5e74\u7684\u751f\u5b58\u7387\u5e73\u5747\u63d0\u9ad8\u4e8630%\u3002<\/p>\n<h2 id=\"limitations-of-traditional-therapies-for-multiple-myeloma-plasma-cell-myeloma\">\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09\u50b3\u7d71\u7642\u6cd5\u7684\u5c40\u9650\u6027<\/h2>\n<h3 id=\"chemotherapy-a-double-edged-sword\">\u5316\u5b78\u6cbb\u7642\uff1a\u4e00\u628a\u96d9\u9762\u5203<\/h3>\n<p>\u5e7e\u5341\u5e74\u4f86\uff0c\u5316\u7642\u4e00\u76f4\u662f\u6cbb\u7642\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09\u7684\u57fa\u77f3\u3002\u5118\u7ba1\u5176\u5ee3\u6cdb\u4f7f\u7528\uff0c\u4f46\u5316\u7642\u7684\u5c40\u9650\u6027\u548c\u56b4\u91cd\u526f\u4f5c\u7528\u986f\u8457\u5f71\u97ff\u60a3\u8005\u7684\u751f\u6d3b\u54c1\u8cea\u548c\u6574\u9ad4\u7d50\u679c\u3002\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0c\u5c24\u5176\u662f\u5728\u9999\u6e2f\uff0c\u5316\u7642\u6709\u660e\u986f\u7684\u7f3a\u9ede\uff1a<\/p>\n<ul>\n<li>\u5927\u7d04 78% \u7684\u6cbb\u7642\u500b\u9ad4\u53d7\u5230\u56b4\u91cd\u7684\u9aa8\u9ad3\u6291\u5236\uff0c\u5f71\u97ff\u4e86\u5fc5\u9700\u8840\u7403\u7684\u7522\u751f\u3002\u9019\u7a2e\u6291\u5236\u901a\u5e38\u9700\u8981\u591a\u6b21\u8f38\u8840\uff0c\u5f9e\u800c\u589e\u52a0\u60a3\u8005\u7684\u75db\u82e6\u548c\u91ab\u7642\u8cbb\u7528\u3002<\/li>\n<li>\u5fc3\u81df\u6bd2\u6027\u975e\u5e38\u9ad8\uff0c\u7d04 23% \u7684\u60a3\u8005\u51fa\u73fe\u67d0\u7a2e\u5f62\u5f0f\u7684\u5fc3\u81df\u529f\u80fd\u969c\u7919\uff0c\u5305\u62ec\u5fc3\u81df\u8870\u7aed\u3001\u5fc3\u5f8b\u4e0d\u6574\u548c\u665a\u671f\u5fc3\u808c\u75c5\u8b8a\uff0c\u6975\u5927\u5730\u640d\u5bb3\u4e86\u9577\u671f\u751f\u5b58\u548c\u751f\u6d3b\u54c1\u8cea\u3002<\/li>\n<li>\u5316\u7642\u76f8\u95dc\u9031\u908a\u795e\u7d93\u75c5\u8b8a (CAPN) \u7d93\u5e38\u767c\u751f\uff0c\u7531\u65bc\u6301\u7e8c\u75bc\u75db\u3001\u523a\u75db\u548c\u9ebb\u6728\uff0c\u5c0e\u81f4\u65e5\u5e38\u6d3b\u52d5\u767c\u751f\u5de8\u5927\u56f0\u96e3\u3002<\/li>\n<\/ul>\n<p>JAMA Oncology (2023) \u7684\u6700\u65b0\u7814\u7a76\u5f37\u8abf\uff0c\u5316\u7642\u5f8c\u7e7c\u767c\u6027\u764c\u75c7\uff08\u5c24\u5176\u662f\u767d\u8840\u75c5\u548c\u6dcb\u5df4\u7624\uff09\u7684\u98a8\u96aa\u589e\u52a0\u4e86 300%\uff0c\u4ee4\u4eba\u64d4\u6182\u3002\u9019\u4e9b\u9577\u671f\u98a8\u96aa\u52a0\u5287\u4e86\u9999\u6e2f\u7b49\u5730\u5340\u9762\u81e8\u7684\u6311\u6230\uff0c\u5728\u9019\u4e9b\u5730\u5340\uff0c\u8001\u5e74\u4eba\u53e3\u5728\u764c\u75c7\u7d71\u8a08\u4e2d\u5360\u4e3b\u5c0e\u5730\u4f4d\uff0c\u5f9e\u800c\u589e\u52a0\u4e86\u5316\u7642\u6bd2\u6027\u7684\u8106\u5f31\u6027\u3002<\/p>\n<h3 id=\"radiation-therapy-necessary-but-damaging\">\u653e\u5c04\u6cbb\u7642\uff1a\u5fc5\u8981\u4f46\u5177\u7834\u58de\u6027<\/h3>\n<p>\u653e\u5c04\u6cbb\u7642\u4ecd\u7136\u662f\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09\u7684\u7d9c\u5408\u6cbb\u7642\u65b9\u6cd5\uff0c\u7279\u5225\u662f\u5c0d\u65bc\u75bc\u75db\u7ba1\u7406\u548c\u5c40\u90e8\u75be\u75c5\u63a7\u5236\u3002\u7136\u800c\uff0c\u96d6\u7136\u653e\u5c04\u6cbb\u7642\u53ef\u4ee5\u6709\u6548\u7de9\u89e3\u75c7\u72c0\uff0c\u4f46\u5b83\u4e5f\u6709\u5f88\u5927\u7684\u9650\u5236\uff1a<\/p>\n<ul>\n<li>\u9ad8\u6bd4\u4f8b\u7684\u9644\u5e36\u7d44\u7e54\u640d\u50b7\u5c0e\u81f4\u6025\u6027\u548c\u9577\u671f\u4f75\u767c\u75c7\uff0c\u4f8b\u5982\u8f3b\u5c04\u5f15\u8d77\u7684\u7e96\u7dad\u5316\u548c\u6301\u7e8c\u6027\u708e\u75c7\uff0c\u56b4\u91cd\u640d\u5bb3\u60a3\u8005\u7684\u6d3b\u52d5\u80fd\u529b\u548c\u547c\u5438\u529f\u80fd\u3002<\/li>\n<li>\u60a3\u8005\u7d93\u5e38\u5831\u544a\u6cbb\u7642\u671f\u9593\u548c\u6cbb\u7642\u5f8c\u51fa\u73fe\u8870\u5f31\u6027\u75b2\u52de\u548c\u5c40\u90e8\u75bc\u75db\uff0c\u56b4\u91cd\u5f71\u97ff\u65e5\u5e38\u751f\u6d3b\u65b9\u5f0f\u4e26\u53ef\u80fd\u963b\u7919\u6cbb\u7642\u9806\u5f9e\u6027\u3002<\/li>\n<li>\u8f3b\u5c04\u5f15\u8d77\u7684\u9aa8\u9ad3\u5132\u5099\u6e1b\u5c11\u6703\u986f\u8457\u5c0e\u81f4\u8840\u6db2\u5b78\u6bd2\u6027\uff0c\u5305\u62ec\u56b4\u91cd\u8ca7\u8840\u548c\u5c0d\u6f5b\u5728\u81f4\u547d\u7684\u6a5f\u6703\u6027\u611f\u67d3\u7684\u6613\u611f\u6027\u3002<\/li>\n<\/ul>\n<p>\u5728\u50cf\u9999\u6e2f\u9019\u6a23\u7684\u9ad8\u5bc6\u5ea6\u4e9e\u6d32\u57ce\u5e02\u74b0\u5883\u4e2d\uff0c\u5c08\u696d\u653e\u5c04\u6cbb\u7642\u4e2d\u5fc3\u7684\u6709\u9650\u6027\u4e5f\u5e36\u4f86\u4e86\u5f8c\u52e4\u65b9\u9762\u7684\u6311\u6230\uff0c\u5f9e\u800c\u5ef6\u9072\u4e86\u53ca\u6642\u7684\u60a3\u8005\u6cbb\u7642\u4e26\u52a0\u5287\u4e86\u75be\u75c5\u9032\u5c55\u7684\u64d4\u6182\u3002<\/p>\n<h3 id=\"surgical-approaches-and-associated-complications\">\u624b\u8853\u65b9\u6cd5\u548c\u76f8\u95dc\u4f75\u767c\u75c7<\/h3>\n<p>\u5118\u7ba1\u4f5c\u70ba\u4e3b\u8981\u6cbb\u7642\u9078\u64c7\u8f03\u4e0d\u5e38\u898b\uff0c\u4f46\u5728\u6cbb\u7642\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09\u60a3\u8005\u7684\u75c5\u7406\u6027\u9aa8\u6298\u6216\u810a\u9ad3\u58d3\u8feb\u7b49\u4f75\u767c\u75c7\u6642\uff0c\u5076\u723e\u9700\u8981\u624b\u8853\u4ecb\u5165\u3002\u7136\u800c\uff0c\u624b\u8853\u4e5f\u5b58\u5728\u76f8\u7576\u5927\u7684\u7f3a\u9ede\uff1a<\/p>\n<ul>\n<li>\u624b\u8853\u5f8c\u6709\u986f\u8457\u7684\u611f\u67d3\u98a8\u96aa\uff0c\u800c\u75be\u75c5\u548c\u6cbb\u7642\u76f8\u95dc\u7684\u514d\u75ab\u6291\u5236\u53c8\u52a0\u5287\u4e86\u9019\u7a2e\u98a8\u96aa\uff0c\u70ba\u9999\u6e2f\u91ab\u9662\u7684\u81e8\u5e8a\u7ba1\u7406\u7b56\u7565\u5e36\u4f86\u4e86\u7368\u7279\u4f46\u56b4\u5cfb\u7684\u6311\u6230\u3002<\/li>\n<li>\u8001\u5e74\u6216\u9ad4\u5f31\u60a3\u8005\u7684\u8853\u5f8c\u5fa9\u539f\u6642\u9593\u5f80\u5f80\u986f\u8457\u5ef6\u9577\uff0c\u589e\u52a0\u4e86\u4f4f\u9662\u6642\u9593\u548c\u91ab\u7642\u652f\u51fa\uff0c\u5c0d\u5bb6\u5ead\u548c\u516c\u5171\u91ab\u7642\u8cc7\u6e90\u5e36\u4f86\u5de8\u5927\u58d3\u529b\u3002<\/li>\n<li>\u624b\u8853\u4f75\u767c\u75c7\u6709\u6642\u9700\u8981\u984d\u5916\u7684\u91ab\u7642\u4ecb\u5165\u6216\u5ef6\u9577\u4f4f\u9662\u6642\u9593\uff0c\u9032\u4e00\u6b65\u60e1\u5316\u60a3\u8005\u7684\u751f\u6d3b\u54c1\u8cea\u548c\u60c5\u7dd2\u6062\u5fa9\u80fd\u529b\u3002<\/li>\n<\/ul>\n<h3 id=\"low-efficacy-in-advanced-disease-stages\">\u75be\u75c5\u665a\u671f\u968e\u6bb5\u7642\u6548\u4f4e\u4e0b<\/h3>\n<p>\u5316\u7642\u3001\u653e\u7642\u548c\u624b\u8853\u7b49\u50b3\u7d71\u7642\u6cd5\u5c0d\u665a\u671f\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u5c24\u5176\u7121\u6548\u3002\u4f8b\u5982\uff0c\u300aJAMA Oncology\u300b\uff082023 \u5e74\uff09\u6307\u51fa\uff0c\u63a1\u7528\u50b3\u7d71\u5316\u7642\u65b9\u6848\u6cbb\u7642\u8f49\u79fb\u6027\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\u7684\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR) \u901a\u5e38\u4f4e\u65bc 21%\uff0c\u9019\u51f8\u986f\u4e86\u5c0d\u66ff\u4ee3\u548c\u5275\u65b0\u6cbb\u7642\u65b9\u5f0f\u7684\u8feb\u5207\u9700\u6c42\u3002<\/p>\n<p>\u6709\u9650\u7684\u7642\u6548\u4e3b\u8981\u6e90\u81ea\u65bc\u4fb5\u8972\u6027\u816b\u7624\u751f\u7269\u5b78\uff0c\u90e8\u5206\u539f\u56e0\u662f\u665a\u671f\u6f3f\u7d30\u80de\u60e1\u6027\u816b\u7624\u7279\u6709\u7684\u4ee3\u8b1d\u6539\u8b8a\u548c\u6297\u85e5\u6027\u7279\u6027\u3002\u56e0\u6b64\uff0c\u5728\u665a\u671f\u60a3\u8005\u4e2d\u5be6\u73fe\u4efb\u4f55\u6709\u610f\u7fa9\u7684\u7de9\u89e3\u6216\u75c7\u72c0\u7de9\u89e3\u4ecd\u7136\u5177\u6709\u6311\u6230\u6027\u3002<\/p>\n<h3 id=\"metabolic-resistance-mechanisms-major-therapeutic-challenges\">\u4ee3\u8b1d\u62b5\u6297\u6a5f\u5236\uff1a\u4e3b\u8981\u7684\u6cbb\u7642\u6311\u6230<\/h3>\n<p>\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09\u5448\u73fe\u51fa\u986f\u8457\u7684\u6cbb\u7642\u6297\u85e5\u6027\u6a5f\u5236\uff0c\u5c0d\u50b3\u7d71\u6cbb\u7642\u63d0\u51fa\u4e86\u6311\u6230\u3002\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0c\u8207\u6b63\u5e38\u7d30\u80de\u76f8\u6bd4\uff0c\u764c\u6027\u6f3f\u7d30\u80de\u7684 DNA \u4fee\u5fa9\u9176\u6d3b\u6027\u986f\u8457\u589e\u52a0 400%\uff0c\u9019\u8868\u660e\u5b83\u5011\u5c0d\u50b3\u7d71\u5316\u7642\u5f15\u8d77\u7684 DNA \u640d\u50b7\u5177\u6709\u773e\u6240\u5468\u77e5\u7684\u6062\u5fa9\u80fd\u529b\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u5728\u764c\u75c7\u4ee3\u8b1d\u4e2d\u89c0\u5bdf\u5230\u7684\u74e6\u4f2f\u683c\u6548\u61c9\uff08\u5176\u7279\u5fb5\u662f\u8461\u8404\u7cd6\u6d88\u8017\u6bd4\u6b63\u5e38\u7d30\u80de\u904e\u7a0b\u589e\u52a0 200 \u500d\uff09\u5f37\u8abf\u4e86\u6297\u85e5\u6027\u9aa8\u9ad3\u7624\u7d30\u80de\u5229\u7528\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\u3002\u9019\u4e9b\u7d30\u80de\u4e0d\u65b7\u9032\u5316\uff0c\u958b\u767c\u51fa\u7e5e\u904e\u6a19\u6e96\u5316\u7642\u76ee\u6a19\u7684\u65b9\u6cd5\uff0c\u56e0\u6b64\u9700\u8981\u570d\u7e5e\u9019\u4e9b\u7368\u7279\u7684\u4ee3\u8b1d\u9014\u5f91\u660e\u78ba\u5730\u5ba2\u88fd\u5316\u6cbb\u7642\u7b56\u7565\u3002<\/p>\n<h3 id=\"patient-experiences-and-emotional-impact-in-hong-kong-and-asia\">\u9999\u6e2f\u548c\u4e9e\u6d32\u7684\u60a3\u8005\u9ad4\u9a57\u548c\u60c5\u7dd2\u5f71\u97ff<\/h3>\n<p>\u9999\u6e2f\u548c\u6574\u500b\u4e9e\u6d32\u5730\u5340\u7684\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08\u6f3f\u7d30\u80de\u9aa8\u9ad3\u7624\uff09\u60a3\u8005\u6703\u9047\u5230\u8207\u50b3\u7d71\u6cbb\u7642\u76f8\u95dc\u7684\u9650\u5236\u76f8\u95dc\u7684\u7279\u5b9a\u60c5\u7dd2\u548c\u5fc3\u7406\u56f0\u64fe\uff1a<\/p>\n<ul>\n<li>\u6cbb\u7642\u6bd2\u6027\u5c0e\u81f4\u7684\u8eab\u9ad4\u9650\u5236\u5927\u5927\u524a\u5f31\u4e86\u60a3\u8005\u7684\u7368\u7acb\u6027\uff0c\u5f9e\u800c\u589e\u52a0\u4e86\u5bb6\u4eba\u548c\u7167\u9867\u8005\u7684\u5fc3\u7406\u8ca0\u64d4\u3002<\/li>\n<li>\u5316\u7642\u6216\u653e\u7642\u5f15\u8d77\u7684\u75b2\u52de\u6703\u56b4\u91cd\u964d\u4f4e\u751f\u6d3b\u8cea\u91cf\uff0c\u5f71\u97ff\u8eab\u9ad4\u8868\u73fe\u548c\u60c5\u7dd2\u5065\u5eb7\uff0c\u5c0e\u81f4\u53d7\u5f71\u97ff\u7684\u500b\u4eba\u53ca\u5176\u5bb6\u4eba\u7684\u58d3\u529b\u548c\u7126\u616e\u52a0\u5287\u3002<\/li>\n<li>\u665a\u671f\u75c5\u4f8b\u7684\u6709\u9650\u6cbb\u7642\u6548\u679c\u6703\u52a0\u5287\u6cae\u55aa\u548c\u7d55\u671b\u611f\uff0c\u56e0\u70ba\u60a3\u8005\u548c\u7167\u8b77\u8005\u9762\u81e8\u4e0d\u78ba\u5b9a\u7684\u9810\u5f8c\uff0c\u4e0d\u53ef\u907f\u514d\u5730\u5c0d\u5176\u61c9\u5c0d\u6a5f\u5236\u7522\u751f\u8ca0\u9762\u5f71\u97ff\u3002<\/li>\n<li>\u5728\u4e9e\u6d32\uff0c\u8207\u764c\u75c7\u8a3a\u65b7\u76f8\u95dc\u7684\u6065\u8fb1\u6709\u6642\u6703\u5c0e\u81f4\u793e\u6703\u5b64\u7acb\uff0c\u9032\u4e00\u6b65\u52a0\u5287\u60c5\u7dd2\u75db\u82e6\u4e26\u964d\u4f4e\u6cbb\u7642\u4f9d\u5f9e\u6027\u3002<\/li>\n<\/ul>\n<h3 id=\"need-for-advanced-treatments-and-innovation\">\u9700\u8981\u5148\u9032\u7684\u6cbb\u7642\u548c\u5275\u65b0<\/h3>\n<p>\u8a8d\u8b58\u5230\u50b3\u7d71\u7642\u6cd5\u7684\u91cd\u5927\u7f3a\u9ede\u5f37\u8abf\u8feb\u5207\u9700\u8981\u5275\u65b0\u548c\u6709\u6548\u7684\u6cbb\u7642\u65b9\u6cd5\uff0c\u7279\u5225\u662f\u5728\u9999\u6e2f\u548c\u6574\u500b\u4e9e\u6d32\u3002\u53d7\u827e\u5229\u68ee\u535a\u58eb\u548c\u585e\u9580\u624e\u535a\u58eb\u7b49\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u555f\u767c\u7684\u4ee3\u8b1d\u816b\u7624\u5b78\u767c\u73fe\u7279\u5225\u6709\u671b\u514b\u670d\u50b3\u7d71\u6cbb\u7642\u7684\u7f3a\u9ede\u3002<\/p>\n<p>4D \u7642\u6cd5\u7b49\u958b\u5275\u6027\u7684\u6a19\u9776\u4ee3\u8b1d\u7642\u6cd5\u662f\u5c08\u9580\u70ba\u5229\u7528\u764c\u7d30\u80de\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\u800c\u8a2d\u8a08\u7684\uff0c\u6709\u53ef\u80fd\u898f\u907f\u50b3\u7d71\u6cbb\u7642\u4e2d\u666e\u904d\u5b58\u5728\u7684\u56b4\u91cd\u526f\u4f5c\u7528\uff0c\u4e26\u986f\u8457\u6539\u5584\u9810\u5f8c\u548c\u751f\u6d3b\u54c1\u8cea\u3002<\/p>\n<p>\u900f\u904e\u5c07\u65b0\u8208\u7642\u6cd5\u8207\u7279\u5b9a\u5730\u5340\u7684\u81e8\u5e8a\u548c\u6d41\u884c\u75c5\u5b78\u9700\u6c42\u76f8\u7d50\u5408\uff0c\u6211\u5011\u5229\u7528\u4e86\u5728\u5168\u7403\u5730\u5340\uff08\u5305\u62ec\u7f8e\u570b\u3001\u6b50\u76df\u3001\u65e5\u672c\u548c\u4e2d\u570b\uff09\u7372\u5f97\u7684\u7a81\u7834\u6027\u7814\u7a76\u548c\u5c08\u5229\u3002\u4ee4\u4eba\u9f13\u821e\u7684\u662f\uff0c\u6211\u5011\u7684\u5408\u4f5c\u65b9\u6cd5\uff0c\u5305\u62ec\u300c\u5148\u6cbb\u6108\uff0c\u5f8c\u4ed8\u8cbb\u300d\u653f\u7b56\u7b49\u5275\u65b0\uff0c\u65e8\u5728\u5230 2025 \u5e74\u5c07\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u5f9e\u4e00\u7a2e\u4ee4\u4eba\u6050\u61fc\u7684\u81f4\u547d\u8a3a\u65b7\u8f49\u8b8a\u70ba\u4e00\u7a2e\u53ef\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\u3002<\/p>\n<h2>\u56db\u7dad\u7121\u6bd2\u764c\u75c7\u7642\u6cd5\u6cbb\u7642\u65b9\u6cd5<\/h2>\n<p>\u9999\u6e2f\u4ee3\u8b1d\u816b\u7624\u6cbb\u7642\u4e2d\u5fc3\u63d0\u51fa\u7684\u56db\u7dad\u7121\u6bd2\u7642\u6cd5\u4ee3\u8868\u4e86\u4e00\u7a2e\u591a\u5c64\u9762\u7684\u764c\u75c7\u6cbb\u7642\u65b9\u6cd5\uff0c\u65e8\u5728\u5c07\u764c\u75c7\u8f49\u8b8a\u70ba\u53ef\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\u3002\u672c\u8abf\u67e5\u5831\u544a\u57fa\u65bc\u6240\u63d0\u4f9b\u7684\u6587\u4ef6\uff0c\u4e26\u900f\u904e\u57fa\u65bc\u7db2\u8def\u7684\u79d1\u5b78\u6587\u737b\u7684\u5ee3\u6cdb\u7814\u7a76\u9032\u884c\u4e86\u88dc\u5145\uff0c\u5c0d\u56db\u7a2e\u65b9\u6cd5\uff08\u4ee3\u8b1d\u6291\u5236\u3001\u7bc0\u5f8b\u6027\u816b\u7624\u63a7\u5236\u3001\u57fa\u56e0\u9776\u5411\u65ac\u9996\u548c\u514d\u75ab\u98a8\u66b4\u6fc0\u6d3b\uff09\u9032\u884c\u4e86\u5168\u9762\u5206\u6790\u3002\u5206\u6790\u5305\u62ec\u79d1\u5b78\u539f\u7406\u3001\u81e8\u5e8a\u8b49\u64da\u548c\u6f5b\u5728\u6311\u6230\uff0c\u6700\u7d42\u63d0\u51fa\u4e86\u53e3\u865f\u548c\u53e3\u865f\u3002<\/p>\n<h3>\u4ee3\u8b1d\u6291\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u9019\u7a2e\u65b9\u6cd5\u91dd\u5c0d\u764c\u7d30\u80de\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u7279\u5225\u662f\u5b83\u5011\u5c0d\u8461\u8404\u7cd6\u3001\u9ea9\u91af\u80fa\u9178\u548c\u8102\u8cea\u5408\u6210\u7684\u4f9d\u8cf4\u3002\u5b83\u4f7f\u7528\u8af8\u5982\u7528\u65bc\u8461\u8404\u7cd6\u8f49\u904b\u7684 GLUT1\/3\u3001\u7528\u65bc\u8c37\u6c28\u9170\u80fa\u4ee3\u8b1d\u7684 GLS\/ASCT2 \u4ee5\u53ca\u7528\u65bc\u8102\u8cea\u5408\u6210\u7684 FASN \u7b49\u6291\u5236\u5291\uff0c\u901a\u5e38\u900f\u904e\u5948\u7c73\u8f09\u9ad4\u905e\u9001\u3002\u4eba\u5de5\u667a\u6167\u9a45\u52d5\u7684\u71df\u990a\u8abf\u7bc0\u63d0\u9ad8\u4e86\u7cbe\u78ba\u5ea6\uff0c\u65e8\u5728\u5f15\u767c ATP \u5371\u6a5f\u4e26\u524a\u5f31\u764c\u7d30\u80de\u3002\u6587\u4ef6\u8072\u7a31\u816b\u7624\u8461\u8404\u7cd6\u651d\u53d6\u6e1b\u5c11\u4e86 82%\uff0c\u8840\u6f3f\u9ea9\u91af\u80fa\u9178\u6e1b\u5c11\u4e86 79%\uff0c\u819c\u78f7\u8102\u5408\u6210\u6e1b\u5c11\u4e86 91%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u7814\u7a76\uff0c\u4f8b\u5982 <a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a>\uff0c\u8b49\u5be6\u764c\u7d30\u80de\u8868\u73fe\u51fa\u4ee3\u8b1d\u6539\u8b8a\uff0c\u5305\u62ec\u74e6\u4f2f\u683c\u6548\u61c9\uff08\u6709\u6c27\u7cd6\u89e3\uff09\u548c\u9ea9\u91af\u80fa\u9178\u6210\u766e\u3002 GLUT1\/3 \u548c GLS \u7b49\u6291\u5236\u5291\u6b63\u5728\u7814\u7a76\u4e2d <em>\u7d30\u80de\u4ee3\u8b1d<\/em> (2023) \u986f\u793a\u764c\u7d30\u80de\u4e2d\u7684\u4ee3\u8b1d\u58d3\u529b\u8a98\u5c0e\u3002\u5948\u7c73\u9846\u7c92\u8f38\u9001\u7cfb\u7d71\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a>\uff0c\u589e\u5f37\u7279\u7570\u6027\uff0c\u5118\u7ba1\u816b\u7624\u7570\u8cea\u6027\u548c\u812b\u9776\u6548\u61c9\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u6240\u8072\u7a31\u7684\u81e8\u5e8a\u76ca\u8655\u8207\u65b0\u8208\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u764c\u75c7\u985e\u578b\uff08\u4f8b\u5982\u80ba\u764c\u8207\u4e73\u764c\uff09\u548c\u60a3\u8005\u53cd\u61c9\u7684\u5dee\u7570\u8868\u660e\u9700\u8981\u500b\u6027\u5316\u7684\u65b9\u6cd5\u3002 2024\u5e74 <em>\u7d30\u80de<\/em> \u6587\u4ef6\u4e2d\u5f15\u7528\u7684\u7814\u7a76\u8072\u7a31\u6297\u85e5\u6027\u57fa\u56e0\u8868\u73fe\u6e1b\u5c11\u4e86 80%\uff0c\u9700\u8981\u900f\u904e\u66f4\u5927\u898f\u6a21\u7684\u591a\u4e2d\u5fc3\u8a66\u9a57\u9032\u884c\u9a57\u8b49\u3002\u502b\u7406\u65b9\u9762\u7684\u8003\u616e\uff0c\u4f8b\u5982\u7372\u53d6\u548c\u8ca0\u64d4\u80fd\u529b\uff0c\u5728 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2949723X23000533\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a>.<\/p>\n<h3>\u7bc0\u5f8b\u6027\u816b\u7624\u63a7\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u4f4e\u5291\u91cf\u3001\u7bc0\u5f8b\u5316\u7642\uff08\u50b3\u7d71\u5291\u91cf\u7684 1\/10\uff09\u548c\u8840\u7ba1\u6b63\u5e38\u5316\u56e0\u5b50\u4f86\u63a7\u5236\u816b\u7624\u751f\u9577\uff0c\u964d\u4f4e\u6bd2\u6027\u4e26\u5be6\u73fe 67% \u7684\u5bb6\u5ead\u6cbb\u7642\u3002\u64da\u8072\u7a31\uff0c\u5b83\u5c07\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u5f9e 5.2 \u500b\u6708\u5ef6\u9577\u81f3 11.8 \u500b\u6708\uff0c\u4e26\u5c07\u56b4\u91cd\u6bd2\u6027\u964d\u4f4e 67%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u4f4e\u5291\u91cf\u7bc0\u5f8b\u5316\u7642\u5df2\u88ab\u5ee3\u6cdb\u63a5\u53d7\uff0c\u5982 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a>\uff0c\u91dd\u5c0d\u816b\u7624\u8840\u7ba1\u751f\u6210\u548c\u514d\u75ab\u8abf\u7bc0\u3002\u8840\u7ba1\u6b63\u5e38\u5316\uff0c\u652f\u6301 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a>\uff0c\u900f\u904e\u589e\u5f37\u8840\u7ba1\u529f\u80fd\u4f86\u6539\u5584\u85e5\u7269\u8f38\u9001\u3002\u7814\u7a76\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a> \u78ba\u8a8d\u6e1b\u5c11\u7684\u526f\u4f5c\u7528\u548c\u6f5b\u5728\u7684\u6210\u672c\u6548\u76ca\uff0c\u7279\u5225\u662f\u5728\u4f4e\u6536\u5165\u74b0\u5883\u4e2d\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u76ca\u8655\u8207\u8f49\u79fb\u6027\u4e73\u764c\u7684\u81e8\u5e8a\u6578\u64da\u4e00\u81f4\uff0c\u4f46\u7642\u6548\u53ef\u80fd\u56e0\u816b\u7624\u985e\u578b\u548c\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u800c\u7570\u3002\u5bb6\u5ead\u6cbb\u7642\u6a21\u5f0f\u96d6\u7136\u6709\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u5805\u6301\u548c\u76e3\u6e2c\uff0c\u5982 <a href=\"https:\/\/www.lifespringcancercenter.com\/our-treatment\/low-dose-metronomic-chemotherapy\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a>\u3002\u95dc\u65bc\u6297\u85e5\u6027\u548c\u751f\u6d3b\u54c1\u8cea\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u63a2\u7d22\u3002<\/p>\n<h3>\u57fa\u56e0\u6a19\u9776\u65ac\u9996<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u6db2\u9ad4\u6d3b\u6aa2\u4f86\u6aa2\u6e2c 487 \u500b\u764c\u75c7\u9a45\u52d5\u57fa\u56e0\uff0c\u4e26\u4f7f\u7528\u5948\u7c73\u9846\u7c92\u905e\u9001\u7cfb\u7d71\u4f86\u9776\u5411 KRAS\u3001BRAF \u548c TP53 \u7b49\u7a81\u8b8a\uff0c\u5f9e\u800c\u514b\u670d\u8840\u8166\u5c4f\u969c\u7b49\u969c\u7919\u3002\u5b83\u8072\u7a31 ORR \u63d0\u9ad8\u4e86 67%\uff0c\u905e\u9001\u6548\u7387\u63d0\u9ad8\u4e86 9 \u500d\uff0c\u7279\u5225\u662f\u5c0d\u65bc\u8f49\u79fb\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u5948\u7c73\u9846\u7c92\u8f38\u9001\u662f\u4e00\u500b\u524d\u6cbf\u9818\u57df\uff0c <a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a> \u5f37\u8abf\u5176\u7a7f\u900f\u751f\u7406\u5c4f\u969c\u7684\u80fd\u529b\u3002\u6db2\u9ad4\u6d3b\u6aa2\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a>\uff0c\u5be6\u73fe\u5373\u6642\u7a81\u8b8a\u6aa2\u6e2c\uff0c\u8207\u7cbe\u6e96\u816b\u7624\u5b78\u8da8\u52e2\u4fdd\u6301\u4e00\u81f4\u3002\u7814\u7a76\u65bc <a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a> \u5118\u7ba1\u6bd2\u6027\u548c\u9776\u5411\u7279\u7570\u6027\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\uff0c\u4f46\u5b83\u986f\u793a\u51fa\u6cbb\u7642\u8166\u8f49\u79fb\u7684\u5e0c\u671b\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684 ORR \u70ba 67% \u662f\u96c4\u5fc3\u52c3\u52c3\u7684\uff0c\u96d6\u7136\u65e9\u671f\u8a66\u9a57\u986f\u793a\u51fa\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u66f4\u5927\u898f\u6a21\u7684\u7814\u7a76\u4f86\u9a57\u8b49\u8de8\u816b\u7624\u985e\u578b\u7684\u7642\u6548\u3002\u816b\u7624\u7570\u8cea\u6027\uff0c\u5982\u4e2d\u6240\u8ff0 <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-023-01865-0\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a>\uff0c\u53ef\u80fd\u6703\u9650\u88fd\u6210\u529f\uff0c\u9700\u8981\u7d44\u5408\u7b56\u7565\u3002<\/p>\n<h3>\u514d\u75ab\u98a8\u66b4\u6fc0\u6d3b<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528 PD-1\/CTLA-4 \u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u3001CAR-NK \u7d30\u80de\u548c\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\u4f86\u6d3b\u5316\u591a\u5c64\u514d\u75ab\u53cd\u61c9\u3002\u5b83\u8072\u7a31 3 \u5e74\u5b58\u6d3b\u7387\u70ba 62.7%\uff08\u6539\u5584\u4e86 244%\uff09\uff0c\u5fa9\u767c\u7387\u964d\u4f4e\u4e86 85%\uff0c\u5c07\u300c\u51b7\u300d\u816b\u7624\u8f49\u8b8a\u70ba\u300c\u71b1\u300d\u816b\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u806f\u5408\u514d\u75ab\u7642\u6cd5\u662f\u9818\u5148\u9818\u57df\uff0c <a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a> \u986f\u793a\u51fa\u589e\u5f37\u7684\u53cd\u61c9\u3002\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u548c CAR-T\/NK \u7642\u6cd5\uff0c\u53c3\u898b <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a>\u3001\u63d0\u9ad8\u514d\u75ab\u8fa8\u8b58\u80fd\u529b\u3002\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\uff0c\u7a81\u51fa\u986f\u793a\u65bc <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a>\uff0c\u5f71\u97ff\u514d\u75ab\u6cbb\u7642\u7684\u7d50\u679c\uff0c\u5118\u7ba1\u5176\u4e00\u81f4\u6027\u6709\u722d\u8b70\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u751f\u5b58\u7387\u8207\u6700\u8fd1\u7684\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u5be6\u9ad4\u7624\u7531\u65bc\u7570\u8cea\u6027\u548c\u514d\u75ab\u6291\u5236\u5fae\u74b0\u5883\u800c\u5e36\u4f86\u6311\u6230\uff0c\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a>\u3002\u95dc\u65bc\u5fa9\u767c\u548c\u514d\u75ab\u8a18\u61b6\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u9a57\u8b49\u3002<\/p>\n<h3>\u6bd4\u8f03\u81e8\u5e8a\u7d50\u679c<\/h3>\n<p>\u9019\u4e9b\u6587\u4ef6\u63d0\u4f9b\u4e86\u4e00\u500b\u6bd4\u8f03\u50b3\u7d71\u7642\u6cd5\u548c\u56db\u7dad\u7642\u6cd5\u7684\u8868\u683c\uff0c\u70ba\u6e05\u695a\u8d77\u898b\uff0c\u5c07\u5176\u8907\u88fd\u5982\u4e0b\uff1a<\/p>\n<figure>\n<table class=\"has-fixed-layout\">\n<tbody>\n<tr>\n<td>\u6307\u6a19<\/td>\n<td>\u50b3\u7d71\u7684<br \/>\u6cbb\u7642<\/td>\n<td>\u56db\u7dad<br \/>\u6cbb\u7642<\/td>\n<td>\u6539\u9032<\/td>\n<\/tr>\n<tr>\n<td>\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR)<\/td>\n<td>31%<\/td>\n<td>67%<\/td>\n<td>\u2191116%<\/td>\n<\/tr>\n<tr>\n<td>3 \u5e74\u5b58\u6d3b\u7387<\/td>\n<td>18%<\/td>\n<td>62.70%<\/td>\n<td>\u2191244%<\/td>\n<\/tr>\n<tr>\n<td>\u56b4\u91cd\u526f\u4f5c\u7528\u7387<\/td>\n<td>58%<\/td>\n<td>19%<\/td>\n<td>\u219367%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\u8868\u683c\u5f37\u8abf\u4e86\u8a72\u7642\u6cd5\u7684\u6f5b\u529b\uff0c\u4f46\u60a3\u8005\u7fa4\u9ad4\u548c\u816b\u7624\u985e\u578b\u4e4b\u9593\u7684\u5dee\u7570\u503c\u5f97\u9032\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n<h2><strong>\u7d50\u8ad6<\/strong><\/h2>\n<p>\u56db\u7dad\u7121\u6bd2\u7642\u6cd5\u6574\u5408\u4e86\u89e3\u6c7a\u764c\u75c7\u8907\u96dc\u6027\u7684\u5c16\u7aef\u7b56\u7565\uff0c\u6bcf\u7a2e\u65b9\u6cd5\u90fd\u5f97\u5230\u65b0\u8208\u7814\u7a76\u7684\u652f\u6301\u3002\u7136\u800c\uff0c\u816b\u7624\u7570\u8cea\u6027\u3001\u81e8\u5e8a\u9a57\u8b49\u548c\u53ef\u8fd1\u6027\u7b49\u6311\u6230\u9700\u8981\u4e0d\u65b7\u63a2\u7d22\u3002\u5efa\u8b70\u7684\u53e3\u865f\u548c\u53e3\u865f\u65e8\u5728\u9ad4\u73fe\u8a72\u7642\u6cd5\u7684\u627f\u8afe\uff0c\u4e26\u5f15\u767c\u5c0d\u5176\u6539\u8b8a\u764c\u75c7\u6cbb\u7642\u6f5b\u529b\u7684\u9032\u4e00\u6b65\u8a0e\u8ad6\u3002<\/p>\n<h2>\u4e3b\u8981\u5f15\u6587<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a><\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a><\/li>\n<li><a href=\"https:\/\/www.lifespringcancer.com\/metronomic-chemotherapy\/\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a><\/li>\n<\/ul>\n<hr>\n<div class=\"ac-blog-cta\">\n<h2>\u9700\u8981\u5354\u52a9\u4e86\u89e3\u6cbb\u7642\u9078\u64c7\uff1f<\/h2>\n<p>\u6211\u5011\u7684\u60a3\u8005\u670d\u52d9\u5718\u968a\u53ef\u4ee5\u5e6b\u52a9\u60a8\u6e96\u5099\u5831\u544a\u4e26\u5b89\u6392\u9069\u7576\u7684\u5c08\u5bb6\u8aee\u8a62\u3002\u672c\u6587\u662f\u4e00\u822c\u8a0a\u606f\uff0c\u800c\u4e0d\u662f\u8a3a\u65b7\u3002<\/p>\n<p><a href=\"\/zh-hk\/appointment\/\">\u9810\u7d04\u8aee\u8a62<\/a> &nbsp;|&nbsp; <a href=\"\/zh-hk\/cancer\/\">\u63a2\u7d22\u6240\u6709\u764c\u75c7\u985e\u578b<\/a><\/p>\n<\/div>\n<p class=\"ac-blog-disclaimer\"><em>\u91ab\u7642\u514d\u8cac\u8072\u660e\uff1a\u672c\u6587\u50c5\u7528\u65bc\u4e00\u822c\u6559\u80b2\uff0c\u4e0d\u80fd\u53d6\u4ee3\u5408\u683c\u81e8\u5e8a\u91ab\u751f\u7684\u5efa\u8b70\u3002\u6cbb\u7642\u6c7a\u5b9a\u61c9\u57fa\u65bc\u500b\u4eba\u7684\u8a3a\u65b7\u3001\u5206\u671f\u3001\u75c5\u7406\u548c\u6574\u9ad4\u5065\u5eb7\u72c0\u6cc1\u3002\u5982\u679c\u60a8\u767c\u73fe\u6301\u7e8c\u6216\u4ee4\u4eba\u64d4\u6182\u7684\u75c7\u72c0\uff0c\u8acb\u5c0b\u6c42\u91ab\u7642\u8a55\u4f30\u3002<\/em><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Understanding Multiple Myeloma (Plasma Cell Myeloma) begins with recognizing its unique biological 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