{"id":379,"date":"2026-06-28T09:00:00","date_gmt":"2026-06-28T09:00:00","guid":{"rendered":"https:\/\/all-cancers.com\/cancer\/small-cell-lung-cancer-sclc-cancer\/"},"modified":"2026-10-29T13:38:07","modified_gmt":"2026-10-29T13:38:07","slug":"small-cell-lung-cancer-sclc-cancer","status":"publish","type":"cancer_type","link":"https:\/\/all-cancers.com\/zh-hk\/cancer\/small-cell-lung-cancer-sclc-cancer\/","title":{"rendered":"\u5c0f\u7d30\u80de\u80ba\u764c (SCLC)"},"content":{"rendered":"<div class=\"ac-blog-article\">\n<p class=\"ac-blog-lead\"><strong>\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u662f\u4e00\u7a2e\u4fb5\u8972\u6027\u80ba\u764c\uff0c\u5176\u7279\u5fb5\u662f\u816b\u7624\u7d30\u80de\u9ad4\u7a4d\u5c0f\u4e14\u589e\u6b96\u8fc5\u901f\u3002\u9019\u7a2e\u764c\u75c7\u4e3b\u8981\u8d77\u6e90\u65bc\u4e2d\u592e\u652f\u6c23\u7ba1\uff0c\u4e26\u8fc5\u901f\u64f4\u6563\u5230\u6dcb\u5df4\u7d50\u548c\u9060\u7aef\u5668\u5b98\uff0c\u4f7f\u5176\u6210\u70ba\u56b4\u91cd\u5f71\u97ff\u60a3\u8005\u751f\u5b58\u548c\u751f\u6d3b\u54c1\u8cea\u7684\u56b4\u91cd\u75be\u75c5\u3002<\/strong><\/p>\n<nav class=\"ac-blog-toc\" aria-label=\"\u672c\u6587\u5c0e\u89bd\">\n<p><strong>\u672c\u6587\u5c0e\u89bd<\/strong><\/p>\n<ul>\n<li><a href=\"#what-is-small-cell-lung-cancer-sclc\">\u4ec0\u9ebc\u662f\u5c0f\u7d30\u80de\u80ba\u764c (SCLC)\uff1f<\/a><\/li>\n<li><a href=\"#causes-and-risk-factors-of-small-cell-lung-cancer-sclc\">\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u7684\u539f\u56e0\u548c\u5371\u96aa\u56e0\u5b50<\/a><\/li>\n<li><a href=\"#symptoms-of-small-cell-lung-cancer-sclc\">\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u7684\u75c7\u72c0<\/a><\/li>\n<li><a href=\"#stages-of-small-cell-lung-cancer-sclc-and-survival-rates\">\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u7684\u5206\u671f\u548c\u5b58\u6d3b\u7387<\/a><\/li>\n<li><a href=\"#limitations-of-traditional-therapies-for-small-cell-lung-cancer-sclc\">\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u50b3\u7d71\u7642\u6cd5\u7684\u5c40\u9650\u6027<\/a><\/li>\n<\/ul>\n<\/nav>\n<h2 id=\"what-is-small-cell-lung-cancer-sclc\">\u4ec0\u9ebc\u662f\u5c0f\u7d30\u80de\u80ba\u764c (SCLC)\uff1f<\/h2>\n<h3 id=\"biological-basis-of-small-cell-lung-cancer-sclc\">\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u7684\u751f\u7269\u5b78\u57fa\u790e<\/h3>\n<p>\u5728\u751f\u7269\u5b78\u5c64\u9762\u4e0a\uff0c <strong>\u5c0f\u7d30\u80de\u80ba\u764c (SCLC)<\/strong> \u7d93\u5e38\u8868\u73fe\u51fa\u7368\u7279\u7684\u4ee3\u8b1d\u8b8a\u5316\uff0c\u7279\u5225\u662f\u74e6\u723e\u5821\u6548\u61c9\u3002\u9019\u7a2e\u73fe\u8c61\u63cf\u8ff0\u4e86\u764c\u7d30\u80de\u5373\u4f7f\u5728\u6709\u6c27\u7684\u60c5\u6cc1\u4e0b\u4e5f\u6703\u53ad\u6c27\u767c\u9175\u8461\u8404\u7cd6\uff0c\u6d88\u8017\u8461\u8404\u7cd6\u7684\u901f\u5ea6\u662f\u6b63\u5e38\u7d30\u80de\u7684\u8fd1200\u500d\uff0c\u5c0e\u81f4\u816b\u7624\u5feb\u901f\u751f\u9577\u548c\u589e\u6b96\u3002<\/p>\n<ul>\n<li>\u5feb\u901f\u8461\u8404\u7cd6\u4ee3\u8b1d\uff08\u74e6\u723e\u5821\u6548\u61c9\uff09<\/li>\n<li>\u9ad8\u5ea6\u4f9d\u8cf4\u7cd6\u89e3\u4f5c\u7528\u548c\u9ea9\u91af\u80fa\u9178\u4ee3\u8b1d<\/li>\n<li>\u764c\u7d30\u80de\u5feb\u901f\u589e\u6b96<\/li>\n<\/ul>\n<h3 id=\"prevalence-and-epidemiology\">\u76db\u884c\u7387\u548c\u6d41\u884c\u75c5\u5b78<\/h3>\n<p>\u6839\u64da\u4e16\u754c\u885b\u751f\u7d44\u7e54 2024 \u5e74\u7684\u6578\u64da\uff0c\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0c\u80ba\u764c\u6bcf\u5e74\u5f71\u97ff\u7d04 220 \u842c\u4eba\u3002\u5c0f\u7d30\u80de\u80ba\u764c\u7d04\u4f54\u6240\u6709\u80ba\u764c\u8a3a\u65b7\u7684 15%\uff0c\u4f46\u7531\u65bc\u5feb\u901f\u9032\u5c55\u548c\u65e9\u671f\u8f49\u79fb\uff0c\u767c\u751f\u7387\u5f88\u9ad8\u3002<\/p>\n<p>\u5728\u9999\u6e2f\u548c\u6771\u4e9e\uff0c\u7531\u65bc\u5340\u57df\u7279\u5b9a\u56e0\u7d20\uff0c\u7279\u5225\u662f\u9ad8\u83f8\u8349\u6d88\u8cbb\u7387\u3001\u7a7a\u6c23\u6c61\u67d3\u548c EGFR \u57fa\u56e0\u7a81\u8b8a\u7b49\u907a\u50b3\u50be\u5411\uff0c\u80ba\u764c\u76db\u884c\u7387\u4ecd\u7136\u5f88\u9ad8\u3002\u50b3\u7d71\u4e0a\uff0c55-70 \u6b72\u7684\u7537\u6027\u4e2d\u66f4\u5e38\u898b\uff0c\u4f46\u6700\u8fd1\u7684\u8da8\u52e2\u986f\u793a\uff0c\u5973\u6027\u548c\u5e74\u8f15\u4eba\u53e3\u7684\u767c\u75c5\u7387\u6709\u6240\u589e\u52a0\u3002<\/p>\n<ul>\n<li>\u9999\u6e2f\u6bcf\u5e74\u65b0\u589e\u500b\u6848\u8d85\u904e 5,000 \u4f8b (2024 \u5e74)<\/li>\n<li>\u8f49\u5411\u66f4\u5e74\u8f15\u7684\u5e74\u9f61\u7d44\u8a3a\u65b7<\/li>\n<li>\u7531\u65bc\u5438\u7159\u65b9\u5f0f\u7684\u8b8a\u5316\uff0c\u5973\u6027\u53d7\u5230\u7684\u5f71\u97ff\u8d8a\u4f86\u8d8a\u5927<\/li>\n<\/ul>\n<h3 id=\"impact-on-patients-emotional-and-physical-burden\">\u5c0d\u75c5\u4eba\u7684\u5f71\u97ff\uff1a\u60c5\u7dd2\u8207\u8eab\u9ad4\u8ca0\u64d4<\/h3>\n<p>\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u8a3a\u65b7\u6703\u5e36\u4f86\u5f37\u70c8\u7684\u60c5\u7dd2\u548c\u8eab\u9ad4\u8ca0\u64d4\u3002\u60a3\u8005\u901a\u5e38\u6703\u51fa\u73fe\u6301\u7e8c\u54b3\u55fd\u3001\u75f0\u4e2d\u5e36\u8840\u3001\u80f8\u75db\u3001\u75b2\u52de\u3001\u9ad4\u91cd\u6e1b\u8f15\u548c\u547c\u5438\u7a98\u8feb\u7b49\u75c7\u72c0\u3002 SCLC \u7684\u653b\u64ca\u6027\u6703\u52a0\u5287\u60c5\u7dd2\u56f0\u64fe\u3001\u7126\u616e\u548c\u5b64\u7acb\u611f\uff0c\u5f37\u8abf\u5bcc\u6709\u540c\u60c5\u5fc3\u548c\u53ca\u6642\u7167\u8b77\u7684\u91cd\u8981\u6027\u3002<\/p>\n<ul>\n<li>\u75bc\u75db\u548c\u547c\u5438\u56f0\u96e3<\/li>\n<li>\u9ad4\u91cd\u6e1b\u8f15\u548c\u75b2\u52de<\/li>\n<li>\u5fc3\u7406\u56f0\u64fe\u8207\u7126\u616e\u52a0\u5287<\/li>\n<\/ul>\n<h2 id=\"causes-and-risk-factors-of-small-cell-lung-cancer-sclc\">\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u7684\u539f\u56e0\u548c\u5371\u96aa\u56e0\u5b50<\/h2>\n<p>\u7406\u89e3 <strong>\u5c0f\u7d30\u80de\u80ba\u764c (SCLC)<\/strong> \u9700\u8981\u8a0e\u8ad6\u67d0\u4e9b\u95dc\u9375\u98a8\u96aa\u56e0\u7d20\u548c\u539f\u56e0\u3002\u9019\u4e9b\u56e0\u7d20\u5305\u62ec\u57fa\u56e0\u7a81\u8b8a\u3001\u751f\u6d3b\u7fd2\u6163\u3001\u74b0\u5883\u66b4\u9732\u548c\u764c\u7d30\u80de\u7368\u7279\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u9019\u4e9b\u90fd\u986f\u8457\u4fc3\u9032\u4e86\u75be\u75c5\u7684\u767c\u751f\u3002<\/p>\n<h3 id=\"genetic-and-molecular-factors\">\u907a\u50b3\u548c\u5206\u5b50\u56e0\u7d20<\/h3>\n<p>\u907a\u50b3\u6539\u8b8a\uff0c\u5c24\u5176\u662f TP53 \u548c RB1 \u7b49\u816b\u7624\u6291\u5236\u57fa\u56e0\u7684\u7a81\u8b8a\uff0c\u901a\u5e38\u8207\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u76f8\u95dc\u3002\u9019\u4e9b\u57fa\u56e0\u7578\u8b8a\u53cd\u6620\u4e86\u73fe\u4ee3\u6cbb\u7642\u65b9\u6cd5\u53ef\u80fd\u91dd\u5c0d\u7684\u8106\u5f31\u6027\u3002<\/p>\n<ul>\n<li>\u7d04 90% \u7684 SCLC \u60a3\u8005\u767c\u751f TP53 \u548c RB1 \u7a81\u8b8a<\/li>\n<li>\u90e8\u5206\u60a3\u8005\u4e5f\u6d89\u53ca PIK3CA\u3001PTEN \u548c EGFR \u7a81\u8b8a<\/li>\n<li>\u6301\u7e8c\u7814\u7a76\u9a45\u52d5\u7684\u500b\u4eba\u5316\u6cbb\u7642\u57fa\u56e0\u5206\u6790<\/li>\n<\/ul>\n<h3 id=\"lifestyle-factors-and-environmental-influences\">\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\u548c\u74b0\u5883\u5f71\u97ff<\/h3>\n<p>\u5438\u83f8\u4ecd\u7136\u662f\u4e3b\u8981\u7684\u5371\u96aa\u56e0\u7d20\uff0c\u5c0e\u81f4 80% \u4ee5\u4e0a\u7684\u5c0f\u7d30\u80de\u80ba\u764c\u75c5\u4f8b\u3002\u7a7a\u6c23\u6c61\u67d3\u7269\u3001\u77f3\u68c9\u3001\u8f3b\u5c04\u548c\u4e8c\u624b\u83f8\u7684\u74b0\u5883\u66b4\u9732\u4e5f\u662f\u91cd\u8981\u7684\u5f71\u97ff\u56e0\u7d20\uff0c\u7279\u5225\u662f\u5728\u9999\u6e2f\u7b49\u4eba\u53e3\u7a20\u5bc6\u7684\u57ce\u5e02\u4e2d\u5fc3\u3002<\/p>\n<ul>\n<li>\u5438\u7159\uff08\u5305\u62ec\u9999\u7159\u3001\u96ea\u8304\u3001\u7159\u9b25\u548c\u4e8c\u624b\u7159\uff09<\/li>\n<li>\u63a5\u89f8\u77f3\u68c9\u3001\u6c21\u6c23\u548c\u5de5\u696d\u6c61\u67d3\u7269<\/li>\n<li>\u9577\u671f\u66b4\u9732\u65bc\u56b4\u91cd\u7684\u57ce\u5e02\u7a7a\u6c23\u6c61\u67d3<\/li>\n<\/ul>\n<h3 id=\"metabolic-dependencies-in-cancer-cells\">\u764c\u7d30\u80de\u7684\u4ee3\u8b1d\u4f9d\u8cf4\u6027<\/h3>\n<p>\u764c\u7d30\u80de\u8868\u73fe\u51fa\u9ad8\u5ea6\u7684\u4ee3\u8b1d\u9748\u6d3b\u6027\uff0c\u4f46\u901a\u5e38\u4f9d\u8cf4\u7279\u5b9a\u7684\u4ee3\u8b1d\u9014\u5f91\uff0c\u4f8b\u5982\u8461\u8404\u7cd6\u548c\u9ea9\u91af\u80fa\u9178\u4ee3\u8b1d\u3002\u7d04 50% \u7684\u764c\u7d30\u80de\uff08\u5305\u62ec SCLC \u7d30\u80de\uff09\u5927\u91cf\u5229\u7528\u9ea9\u91af\u80fa\u9178\u9032\u884c\u6838\u82f7\u9178\u5408\u6210\u3001\u8a0a\u865f\u50b3\u5c0e\u8def\u5f91\u548c\u7dad\u6301\u589e\u6b96\u80fd\u529b\u3002<\/p>\n<ul>\n<li>\u9ad8\u5ea6\u4f9d\u8cf4\u8461\u8404\u7cd6\u767c\u9175\uff08\u74e6\u723e\u5821\u6548\u61c9\uff09<\/li>\n<li>\u7d30\u80de\u589e\u6b96\u548c\u5b58\u6d3b\u5c0d\u9ea9\u91af\u80fa\u9178\u7684\u4f9d\u8cf4<\/li>\n<li>\u4ee3\u8b1d\u6291\u5236\u5291\uff08\u4f8b\u5982 GLS \u6291\u5236\u5291\uff09\u7684\u6f5b\u5728\u6cbb\u7642\u6a19\u9776<\/li>\n<\/ul>\n<h3 id=\"specific-risks-in-hong-kong-and-asia\">\u9999\u6e2f\u548c\u4e9e\u6d32\u7684\u7279\u5b9a\u98a8\u96aa<\/h3>\n<p>\u5728\u4e9e\u6d32\uff0c\u7279\u5225\u662f\u9999\u6e2f\uff0c\u51fa\u73fe\u4e86\u7368\u7279\u7684\u5340\u57df\u98a8\u96aa\u6a21\u5f0f\u3002\u5438\u7159\u7387\u4e0a\u5347\u3001\u5ee3\u6cdb\u7684\u57ce\u5e02\u6c61\u67d3\u3001\u98f2\u98df\u751f\u6d3b\u65b9\u5f0f\u548c\u907a\u50b3\u6613\u611f\u6027\uff08\u4f8b\u5982\u6771\u4e9e\u4eba\u7fa4\u4e2d\u983b\u7e41\u51fa\u73fe\u7684 EGFR \u7a81\u8b8a\u6d41\u884c\uff09\u5275\u9020\u4e86\u4e00\u500b\u7368\u7279\u7684\u74b0\u5883\uff0c\u5c0e\u81f4\u8a72\u5730\u5340\u51fa\u73fe\u660e\u986f\u7684\u98a8\u96aa\u805a\u96c6\u3002<\/p>\n<ul>\n<li>EGFR \u7a81\u8b8a\u5728\u4e9e\u6d32\u4eba\u7fa4\u4e2d\u666e\u904d\u5b58\u5728\uff08\u7d04\u4f54\u60a3\u8005\u75c5\u4f8b\u7684 40-50%\uff09<\/li>\n<li>\u4eba\u53e3\u5bc6\u5ea6\u9ad8\u5c0e\u81f4\u57ce\u5e02\u6c61\u67d3\u52a0\u5287<\/li>\n<li>\u98f2\u98df\u5f71\u97ff\u548c\u751f\u6d3b\u65b9\u5f0f\u9a45\u52d5\u56e0\u7d20\uff08\u9ad8\u8102\u80aa\u98f2\u98df\u548c\u7f3a\u4e4f\u9ad4\u529b\u6d3b\u52d5\uff09<\/li>\n<\/ul>\n<h3 id=\"preventive-and-early-detection-measures\">\u9810\u9632\u548c\u65e9\u671f\u767c\u73fe\u63aa\u65bd<\/h3>\n<p>\u4fc3\u9032\u65e9\u671f\u7be9\u6aa2\uff0c\u4f8b\u5982\u5b9a\u671f\u9032\u884c\u80f8\u90e8 X \u5149\u6aa2\u67e5\u3001\u5c0d\u9ad8\u98a8\u96aa\u65cf\u7fa4\u9032\u884c\u4f4e\u5291\u91cf CT \u6383\u63cf\u4ee5\u53ca\u5c0d\u6613\u611f\u4eba\u7fa4\u9032\u884c\u907a\u50b3\u8aee\u8a62\uff0c\u53ef\u986f\u8457\u6539\u5584 SCLC \u60a3\u8005\u7684\u9810\u5f8c\u3002\u5c0d\u5927\u773e\u9032\u884c\u53ef\u6539\u8b8a\u7684\u98a8\u96aa\u56e0\u7d20\uff08\u4f8b\u5982\u6212\u83f8\u3001\u6539\u5584\u751f\u6d3b\u65b9\u5f0f\u548c\u74b0\u5883\u5e79\u9810\uff09\u7684\u6559\u80b2\u4ecd\u7136\u52e2\u5728\u5fc5\u884c\u3002<\/p>\n<ul>\n<li>\u5b9a\u671f\u7be9\u6aa2\u548c\u65e9\u671f\u8a3a\u65b7\u6e2c\u8a66<\/li>\n<li>\u6539\u8b8a\u751f\u6d3b\u65b9\u5f0f\uff08\u6212\u83f8\u3001\u66f4\u5065\u5eb7\u7684\u98f2\u98df\u7fd2\u6163\uff09<\/li>\n<li>\u7cbe\u6e96\u91ab\u7642\u548c\u500b\u4eba\u5316\u7ba1\u7406<\/li>\n<\/ul>\n<p><a href=\"\/zh-hk\/treatment-cancer\/\">\u4e86\u89e3 4D \u7642\u6cd5\u5982\u4f55\u6539\u8b8a\u5c0f\u7d30\u200b\u200b\u80de\u80ba\u764c (SCLC) \u6cbb\u7642<\/a><\/p>\n<p>\u63a2\u7d22\u5e0c\u671b\u548c\u5eb7\u5fa9\u7684\u6545\u4e8b\uff0c\u5305\u62ec <a href=\"\/zh-hk\/about\/\">\u7d04\u7ff0\u7684\u80ba\u764c\u900f\u904e 4D \u7642\u6cd5\u5f97\u5230\u7de9\u89e3<\/a>\uff0c\u6211\u5011\u7684\u76ee\u6a19\u662f\u5230 2025 \u5e74\u4f7f\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u6210\u70ba\u4e00\u7a2e\u6162\u6027\u4e14\u53ef\u63a7\u5236\u7684\u75be\u75c5\u3002<\/p>\n<h2 id=\"symptoms-of-small-cell-lung-cancer-sclc\">\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u7684\u75c7\u72c0<\/h2>\n<p>\u8a8d\u8b58\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u7684\u75c7\u72c0\u5c0d\u65bc\u65e9\u671f\u767c\u73fe\u3001\u6539\u5584\u9810\u5f8c\u548c\u53ca\u6642\u4ecb\u5165\u81f3\u95dc\u91cd\u8981\u3002\u75c7\u72c0\u5f80\u5f80\u56e0\u968e\u6bb5\u800c\u7570\uff0c\u4e26\u6703\u6975\u5927\u5730\u5f71\u97ff\u60a3\u8005\u7684\u751f\u6d3b\u54c1\u8cea\u3002\u719f\u6089\u9019\u4e9b\u6307\u6a19\u5c0d\u65bc\u65e9\u671f\u8a3a\u65b7\u662f\u5fc5\u8981\u7684\u3002<\/p>\n<h3 id=\"common-early-stage-symptoms-of-small-cell-lung-cancer-sclc\">\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u7684\u5e38\u898b\u65e9\u671f\u75c7\u72c0<\/h3>\n<ul>\n<li>\u6a19\u6e96\u611f\u5192\u6216\u6d41\u611f\u6cbb\u7642\u7121\u6cd5\u89e3\u6c7a\u7684\u6301\u7e8c\u54b3\u55fd<\/li>\n<li>\u8072\u97f3\u6c99\u555e\u6301\u7e8c\u5169\u9031\u4ee5\u4e0a<\/li>\n<li>\u80f8\u90e8\u4e0d\u9069\u6216\u920d\u75db<\/li>\n<li>\u54af\u8840\u767c\u4f5c\uff08\u54b3\u8840\uff09<\/li>\n<li>\u4e0d\u660e\u539f\u56e0\u7684\u75b2\u52de\u56b4\u91cd\u9650\u5236\u4e86\u65e5\u5e38\u6d3b\u52d5<\/li>\n<li>\u652f\u6c23\u7ba1\u708e\u6216\u80ba\u708e\u7b49\u80ba\u90e8\u611f\u67d3\u8d8a\u4f86\u8d8a\u5e38\u767c\u4f5c<\/li>\n<\/ul>\n<h3 id=\"symptoms-reflecting-tumor-biology\">\u53cd\u6620\u816b\u7624\u751f\u7269\u5b78\u7684\u75c7\u72c0<\/h3>\n<p>\u5c0f\u7d30\u80de\u80ba\u764c\uff08SCLC\uff09\u5177\u6709\u7531\u5feb\u901f\u589e\u6b96\u7684\u60e1\u6027\u7d30\u80de\u9a45\u52d5\u7684\u7368\u7279\u751f\u7269\u5b78\u7279\u6027\u3002\u4e86\u89e3\u816b\u7624\u751f\u7269\u5b78\u6709\u52a9\u65bc\u6211\u5011\u5c07\u75c7\u72c0\u8207\u7279\u5b9a\u7684\u75c5\u7406\u6a5f\u5236\u9023\u7d50\u8d77\u4f86\uff1a<\/p>\n<ul>\n<li>\u6301\u7e8c\u54b3\u55fd\u4e3b\u8981\u662f\u816b\u7624\u5f15\u8d77\u7684\u6c23\u9053\u523a\u6fc0\u548c\u963b\u585e\u3002<\/li>\n<li>\u7576\u816b\u7624\u4fb5\u5165\u652f\u6c23\u7ba1\u58c1\u5167\u7684\u8106\u5f31\u8840\u7ba1\u6642\uff0c\u5c31\u6703\u767c\u751f\u54b3\u8840\u3002<\/li>\n<li>\u8072\u97f3\u6c99\u555e\u8207\u5589\u8fd4\u795e\u7d93\u4fb5\u72af\u6709\u95dc\uff0c\u9019\u662f\u4e00\u500b\u9700\u8981\u7acb\u5373\u8a55\u4f30\u7684\u8de1\u8c61\u3002<\/li>\n<li>\u983b\u7e41\u7684\u80ba\u90e8\u611f\u67d3\u8868\u793a\u514d\u75ab\u53cd\u61c9\u53d7\u640d\u548c\u816b\u7624\u751f\u9577\u5c0e\u81f4\u6c23\u9053\u963b\u585e\u3002<\/li>\n<\/ul>\n<h3 id=\"advanced-stage-symptoms-of-small-cell-lung-cancer-sclc\">\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u7684\u665a\u671f\u75c7\u72c0<\/h3>\n<ul>\n<li>\u8f49\u79fb\u5f15\u8d77\u7684\u56b4\u91cd\u9aa8\u75db\uff0c\u5e38\u898b\u65bc\u75be\u75c5\u665a\u671f<\/li>\n<li>\u8166\u8f49\u79fb\u5f15\u8d77\u7684\u795e\u7d93\u7cfb\u7d71\u8868\u73fe\uff0c\u5982\u982d\u75db\u3001\u982d\u6688\u6216\u7672\u7647\u767c\u4f5c<\/li>\n<li>\u764c\u75c7\u5f15\u8d77\u7684\u4ee3\u8b1d\u8b8a\u5316\u5c0e\u81f4\u4e0d\u660e\u539f\u56e0\u7684\u9ad4\u91cd\u6e1b\u8f15\u548c\u53ad\u98df<\/li>\n<li>\u60e1\u6027\u80f8\u8154\u7a4d\u6c34\uff08\u80ba\u90e8\u5468\u570d\u7a4d\u6c34\uff09\u5c0e\u81f4\u75bc\u75db\u816b\u8139\u548c\u54b3\u55fd<\/li>\n<li>\u98df\u9053\u53d7\u58d3\u6216\u4fb5\u5165\u5c0e\u81f4\u541e\u56a5\u56f0\u96e3<\/li>\n<li>\u7121\u529b\u6216\u9ebb\u6728\u901a\u5e38\u662f\u7531\u810a\u9ad3\u53d7\u58d3\u5f15\u8d77\u7684\uff08\u8207\u810a\u67f1\u8f49\u79fb\u76f8\u95dc\uff09<\/li>\n<\/ul>\n<p>\u91ab\u5b78\u5c08\u5bb6\u7684\u65e9\u671f\u8a55\u4f30\u548c\u8a3a\u65b7\u53ef\u4ee5\u986f\u8457\u6539\u5584\u7d50\u679c\u3002\u5982\u679c\u60a8\u51fa\u73fe\u4efb\u4f55\u6301\u7e8c\u7684\u547c\u5438\u9053\u75c7\u72c0\uff0c\u8acb\u7acb\u5373\u8aee\u8a62\u91ab\u7642\u4fdd\u5065\u63d0\u4f9b\u8005\u4ee5\u9032\u884c\u9069\u7576\u7684\u8abf\u67e5\u548c\u500b\u4eba\u5316\u7684\u6cbb\u7642\u8a08\u5283\u3002<\/p>\n<h2 id=\"stages-of-small-cell-lung-cancer-sclc-and-survival-rates\">\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u7684\u5206\u671f\u548c\u5b58\u6d3b\u7387<\/h2>\n<p>\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u7684\u5206\u671f\u5728\u78ba\u5b9a\u9810\u5f8c\u548c\u9078\u64c7\u6700\u6709\u6548\u7684\u6cbb\u7642\u65b9\u6cd5\u65b9\u9762\u767c\u63ee\u95dc\u9375\u4f5c\u7528\u3002\u53ea\u6709\u6e96\u78ba\u7684\u5206\u671f\u5224\u65b7\uff0c\u60a3\u8005\u624d\u80fd\u9054\u5230\u6700\u4f73\u7684\u6cbb\u7642\u6548\u679c\u3002\u4e0d\u540c\u968e\u6bb5\u7684\u5b58\u6d3b\u7387\u5dee\u7570\u5f88\u5927\uff0c\u4e26\u76f4\u63a5\u5f71\u97ff\u6cbb\u7642\u7b56\u7565\u3002<\/p>\n<h3 id=\"stage-1-small-cell-lung-cancer-sclc\">\u7b2c\u4e00\u968e\u6bb5 \u2013 \u5c0f\u7d30\u80de\u80ba\u764c (SCLC)<\/h3>\n<p>\u7b2c\u4e00\u968e\u6bb5\u7684\u7279\u5fb5\u662f\u5c40\u90e8\u816b\u7624\u56b4\u683c\u5c40\u9650\u65bc\u4e00\u5074\u80ba\u5167\uff0c\u901a\u5e38\u5c0f\u65bc 3 \u5398\u7c73\uff0c\u6c92\u6709\u6dcb\u5df4\u7d50\u53d7\u7d2f\u3002\u5728\u9999\u6e2f\u548c\u4e9e\u6d32\uff0c\u5b83\u7d04\u4f54\u78ba\u8a3a SCLC \u7684 5-10%\u3002<\/p>\n<ul>\n<li><strong>\u6cbb\u7642\u65b9\u6848\uff1a<\/strong>\n<ul>\n<li>\u5c0d\u65bc\u7b26\u5408\u689d\u4ef6\u7684\u60a3\u8005\uff0c\u624b\u8853\u6709\u53ef\u80fd\u6cbb\u7652\u3002<\/li>\n<li>\u653e\u5c04\u6cbb\u7642\u53ef\u4ee5\u986f\u8457\u63d0\u9ad8\u624b\u8853\u6216\u7368\u7acb\u6cbb\u7642\u7684\u6548\u679c\u3002<\/li>\n<li>\u65e9\u671f\u5316\u7642\u65b9\u6848\u6709\u52a9\u65bc\u986f\u8457\u6e1b\u5c11\u5fa9\u767c\u3002<\/li>\n<\/ul>\n<\/li>\n<li><strong>\u5b58\u6d3b\u7387\uff1a<\/strong>\n<ul>\n<li>\u5728\u7b2c\u4e00\u968e\u6bb5\u8a3a\u65b7\u7684\u60a3\u8005\u900f\u904e\u7d9c\u5408\u6cbb\u7642\u5e79\u9810\uff0c\u4e94\u5e74\u5b58\u6d3b\u7387\u53ef\u671b\u9054\u5230 50-60%\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3 id=\"stage-2-small-cell-lung-cancer-sclc\">\u968e\u6bb5 2 \u2013 \u5c0f\u7d30\u80de\u80ba\u764c (SCLC)<\/h3>\n<p>2 \u671f\u8868\u793a\u539f\u767c\u816b\u7624\u64f4\u5927\u8d85\u904e 3 \u516c\u5206\u6216\u53d7\u5f71\u97ff\u80ba\u90e8\u9644\u8fd1\u5c40\u90e8\u6dcb\u5df4\u7d50\u53d7\u7d2f\u6709\u9650\u3002<\/p>\n<ul>\n<li><strong>\u6cbb\u7642\u65b9\u6848\uff1a<\/strong>\n<ul>\n<li>\u5408\u4f75\u5316\u7642\u548c\u653e\u7642\u662f\u4e3b\u8981\u7684\u6cbb\u7642\u652f\u67f1\u3002<\/li>\n<li>\u9078\u64c7\u6027\u5730\u8003\u616e\u624b\u8853\uff0c\u901a\u5e38\u8207\u8f14\u52a9\u5316\u7642\u76f8\u7d50\u5408\u3002<\/li>\n<li>\u8207\u55ae\u7368\u5316\u7642\u76f8\u6bd4\uff0c\u591a\u6a21\u5f0f\u7642\u6cd5\u53ef\u63d0\u9ad8\u5b58\u6d3b\u7387\u3002<\/li>\n<\/ul>\n<\/li>\n<li><strong>\u5b58\u6d3b\u7387\uff1a<\/strong>\n<ul>\n<li>\u5728\u5305\u62ec\u9999\u6e2f\u5728\u5167\u7684\u4e9e\u6d32\u4eba\u7fa4\u4e2d\uff0c\u900f\u904e\u7a4d\u6975\u7684\u591a\u6a21\u5f0f\u6cbb\u7642\uff0c2 \u671f\u60a3\u8005\u7684\u4e94\u5e74\u5b58\u6d3b\u7387\u7d04\u70ba 30-40%\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3 id=\"stage-3-small-cell-lung-cancer-sclc\">\u968e\u6bb5 3 \u2013 \u5c0f\u7d30\u80de\u80ba\u764c (SCLC)<\/h3>\n<p>\u5728\u7b2c\u4e09\u968e\u6bb5\uff0c\u764c\u75c7\u5ee3\u6cdb\u64f4\u6563\u5230\u80f8\u90e8\u5169\u5074\u7684\u6dcb\u5df4\u7d50\u6216\u4fb5\u5165\u80f8\u90e8\u7684\u9130\u8fd1\u7d50\u69cb\u3002\u9019\u7a2e\u5340\u57df\u6027\u665a\u671f\u764c\u75c7\u9700\u8981\u5168\u9762\u7684\u7cfb\u7d71\u6027\u6cbb\u7642\u65b9\u6cd5\u3002<\/p>\n<ul>\n<li><strong>\u6cbb\u7642\u65b9\u6848\uff1a<\/strong>\n<ul>\n<li>\u540c\u6b65\u5316\u7642\u548c\u653e\u7642\u662f\u4e00\u7a2e\u5b8c\u6574\u7684\u6cbb\u7642\u7b56\u7565\u3002<\/li>\n<li>\u7531\u5289\u570b\u9f8d\u6559\u6388\u7b49\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u4e3b\u5c0e\u7684\u65b0\u8208\u4ee3\u8b1d\u7642\u6cd5\u548c\u514d\u75ab\u7642\u6cd5\u7814\u7a76\u53ef\u671b\u986f\u8457\u63d0\u9ad8\u6574\u9ad4\u7de9\u89e3\u7387\u3002<\/li>\n<li>\u8003\u616e\u624b\u8853\u7684\u60c5\u6cc1\u5f88\u5c11\u898b\uff0c\u4f46\u5728\u6dcb\u5df4\u7d50\u53d7\u7d2f\u6709\u9650\u7684\u60c5\u6cc1\u4e0b\u662f\u53ef\u80fd\u7684\u3002<\/li>\n<\/ul>\n<\/li>\n<li><strong>\u5b58\u6d3b\u7387\uff1a<\/strong>\n<ul>\n<li>\u5728\u9999\u6e2f\u548c\u66f4\u5ee3\u6cdb\u7684\u4e9e\u6d32\u4eba\u53e3\u7d71\u8a08\u4e2d\uff0c\u5927\u7d04 15-25% \u7684\u60a3\u8005\u5728\u8a3a\u65b7\u5f8c\u5b58\u6d3b\u4e94\u5e74\uff0c\u9019\u8868\u660e\u65b0\u7a4e\u7684\u6cbb\u7642\u5275\u65b0\u986f\u8457\u6539\u5584\u4e86\u7d50\u679c\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3 id=\"stage-4-small-cell-lung-cancer-sclc\">\u7b2c\u56db\u968e\u6bb5 \u2013 \u5c0f\u7d30\u80de\u80ba\u764c (SCLC)<\/h3>\n<p>\u7b2c\u56db\u968e\u6bb5\u662f\u8f49\u79fb\u6027\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u7684\u7279\u5fb5\uff0c\u610f\u5473\u8457\u8a72\u75be\u75c5\u5df2\u5f9e\u80f8\u90e8\u7d50\u69cb\u64f4\u6563\u5230\u5927\u8166\u3001\u809d\u81df\u6216\u9aa8\u9abc\u7b49\u9060\u7aef\u5668\u5b98\u90e8\u4f4d\uff0c\u6a19\u8a8c\u8457\u75be\u75c5\u5df2\u9032\u5165\u665a\u671f\u3002<\/p>\n<ul>\n<li><strong>\u6cbb\u7642\u65b9\u6848\uff1a<\/strong>\n<ul>\n<li>\u5168\u8eab\u5316\u7642\u4ecd\u662f\u6cbb\u7642\u7684\u57fa\u77f3\u3002<\/li>\n<li>\u6709\u91dd\u5c0d\u6027\u7684\u4ee3\u8b1d\u5e79\u9810\u5229\u7528\u764c\u7d30\u80de\u7684\u7368\u7279\u5f31\u9ede\uff0c\u63d0\u4f9b\u4e86\u6709\u5e0c\u671b\u7684\u8f14\u52a9\u6cbb\u7642\u3002<\/li>\n<li>\u7d93\u7f8e\u570b FDA\u3001EMA \u6279\u51c6\u4e26\u901a\u904e\u5168\u7403\u79d1\u5b78\u5408\u4f5c\u8a8d\u8b49\u7684\u514d\u75ab\u7642\u6cd5\u548c\u5148\u9032\u4ee3\u8b1d\u7642\u6cd5\u9810\u8a08\u5c07\u7a69\u5b9a\u75be\u75c5\u4e26\u6539\u5584\u751f\u6d3b\u8cea\u91cf\uff0c\u65e8\u5728\u5be6\u73fe\u9577\u671f\u7ba1\u7406\u3002<\/li>\n<\/ul>\n<\/li>\n<li><strong>\u5b58\u6d3b\u7387\uff1a<\/strong>\n<ul>\n<li>\u50b3\u7d71\u4e0a\uff0c\u5927\u7d04 3-8% \u7684\u7b2c\u56db\u968e\u6bb5\u8a3a\u65b7\u60a3\u8005\u5b58\u6d3b\u6642\u9593\u8d85\u904e\u4e94\u5e74\uff1b\u9999\u6e2f\u548c\u4e9e\u6d32\u6cbb\u7642\u4e2d\u5fc3\u63a1\u7528\u7684\u65b0\u7642\u6cd5\u986f\u8457\u63d0\u9ad8\u4e86\u9019\u4e9b\u6bd4\u7387\uff0c\u900f\u904e\u7cbe\u5fc3\u7b56\u5283\u7684\u5275\u65b0\u7642\u6cd5\uff0c\u4e09\u5e74\u5b58\u6d3b\u7387\u53ef\u80fd\u9054\u5230 20-30%\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\u5f37\u8abf\u5148\u9032\u6cbb\u7642\u5e36\u4f86\u7684\u5e0c\u671b\u548c\u53ef\u884c\u7684\u53ef\u80fd\u6027\uff0c\u5305\u62ec\u8207\u6df1\u5733\u524d\u6d77\u6cf0\u5eb7\u548c MD \u5b89\u5fb7\u68ee\u5408\u4f5c\u958b\u5275\u7684\u5c16\u7aef 4D \u6cbb\u7642\u9805\u76ee\uff0c\u5f37\u8abf\u5373\u4f7f\u5728\u665a\u671f\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u4e2d\uff0c\u524d\u666f\u4e5f\u9010\u6f38\u5149\u660e\u3002<\/p>\n<h2 id=\"limitations-of-traditional-therapies-for-small-cell-lung-cancer-sclc\">\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u50b3\u7d71\u7642\u6cd5\u7684\u5c40\u9650\u6027<\/h2>\n<h3 id=\"toxicity-concerns-with-chemotherapy\">\u5316\u7642\u7684\u6bd2\u6027\u554f\u984c<\/h3>\n<p>\u5316\u7642\u4ecd\u7136\u662f\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u7684\u6a19\u6e96\u4e00\u7dda\u6cbb\u7642\u65b9\u6cd5\u3002\u5118\u7ba1\u5ee3\u6cdb\u4f7f\u7528\uff0c\u5316\u7642\u901a\u5e38\u6703\u5c0e\u81f4\u986f\u8457\u7684\u6bd2\u6027\uff0c\u5c0d\u60a3\u8005\u7684\u751f\u6d3b\u54c1\u8cea\u548c\u6574\u9ad4\u5fa9\u539f\u7522\u751f\u4e0d\u5229\u5f71\u97ff\u3002 JAMA Oncology (2023) \u7684\u6578\u64da\u5831\u544a\u7a31\uff0c\u63a5\u53d7 SCLC \u5316\u7642\u7684\u60a3\u8005\u4e2d\u8fd1 78% \u60a3\u6709\u9aa8\u9ad3\u6291\u5236\u3002\u9019\u7a2e\u60c5\u6cc1\u6703\u8fc5\u901f\u5347\u7d1a\uff0c\u5c0e\u81f4\u56b4\u91cd\u8ca7\u8840\u3001\u611f\u67d3\u98a8\u96aa\u589e\u52a0\u548c\u514d\u75ab\u53cd\u61c9\u53d7\u640d\u3002<\/p>\n<ul>\n<li>\u7d04 78% \u7684\u60a3\u8005\u6703\u51fa\u73fe\u9aa8\u9ad3\u6291\u5236\u3002<\/li>\n<li>23% \u51fa\u73fe\u5fc3\u81df\u6bd2\u6027\u75c7\u72c0\uff0c\u5305\u62ec\u5fc3\u808c\u75c5\u8b8a\u548c\u5fc3\u5f8b\u4e0d\u6574\u3002<\/li>\n<li>\u5316\u7642\u5f15\u8d77\u7684\u5468\u908a\u795e\u7d93\u75c5\u8b8a (CIPN) \u767c\u751f\u5728\u5927\u7d04 40% \u7684\u63a5\u53d7\u6cbb\u7642\u7684\u500b\u9ad4\u4e2d\uff0c\u901a\u5e38\u6703\u5c0e\u81f4\u7d42\u751f\u4e0d\u9069\u4e26\u9650\u5236\u60a3\u8005\u7684\u65e5\u5e38\u6d3b\u52d5\u3002<\/li>\n<li>\u80c3\u8178\u9053\u4e0d\u9069\uff08\u5c24\u5176\u662f\u5641\u5fc3\u548c\u5614\u5410\uff09\u7684\u767c\u751f\u7387\u5f88\u9ad8\uff0c\u5f71\u97ff\u4e86\u8fd1 60% \u60a3\u8005\u7684\u71df\u990a\u72c0\u6cc1\u3002<\/li>\n<\/ul>\n<p>\u6b64\u5916\uff0c\u5316\u7642\u6291\u5236\u6b63\u5e38\u5feb\u901f\u5206\u88c2\u7684\u7d30\u80de\uff0c\u9020\u6210\u5ee3\u6cdb\u7684\u9644\u5e36\u640d\u5bb3\u3002\u60a3\u8005\u7d93\u5e38\u9762\u81e8\u4ee4\u4eba\u8870\u5f31\u7684\u75b2\u52de\uff0c\u6975\u5927\u5730\u5f71\u97ff\u4e86\u4ed6\u5011\u7dad\u6301\u6b63\u5e38\u751f\u6d3b\u7684\u80fd\u529b\u2014\u2014\u4ed6\u5011\u7d93\u5e38\u5728\u5de5\u4f5c\u548c\u65e5\u5e38\u8cac\u4efb\u4e2d\u6399\u624e\u3002\u56e0\u6b64\uff0c\u5316\u7642\u7684\u7d2f\u7a4d\u6bd2\u6027\u6703\u9650\u5236\u6cbb\u7642\u7684\u9023\u7e8c\u6027\uff0c\u4e26\u964d\u4f4e\u6574\u9ad4\u6cbb\u7642\u7d50\u679c\u3002<\/p>\n<h3 id=\"radiation-therapy-and-associated-risks\">\u653e\u5c04\u6cbb\u7642\u53ca\u76f8\u95dc\u98a8\u96aa<\/h3>\n<p>\u653e\u5c04\u6cbb\u7642\u901a\u5e38\u8207\u5316\u7642\u4e00\u8d77\u4f7f\u7528\uff0c\u5728\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u7684\u6cbb\u7642\u4e2d\u767c\u63ee\u91cd\u8981\u4f5c\u7528\u3002\u5118\u7ba1\u5982\u6b64\uff0c\u5b83\u4e5f\u5177\u6709\u660e\u986f\u7684\u5c40\u9650\u6027\u548c\u9577\u671f\u98a8\u96aa\uff1a<\/p>\n<ul>\n<li>\u653e\u5c04\u6027\u80ba\u708e\uff1a\u5c0d\u9ad8\u9054 25% \u7684\u60a3\u8005\u7684\u80ba\u529f\u80fd\u7522\u751f\u4e0d\u5229\u5f71\u97ff\u3002<\/li>\n<li>\u7d44\u7e54\u7e96\u7dad\u5316\uff1a\u9577\u671f\u63a5\u53d7\u6cbb\u7642\u5f8c\uff0c\u7d04 15% \u7684\u60a3\u8005\u6703\u51fa\u73fe\u4e0d\u53ef\u9006\u7684\u7d44\u7e54\u75a4\u75d5\uff0c\u9032\u800c\u986f\u8457\u964d\u4f4e\u80ba\u529f\u80fd\u548c\u5bb9\u91cf\u3002<\/li>\n<li>\u7e7c\u767c\u6027\u60e1\u6027\u816b\u7624\uff1a\u9577\u671f\u653e\u5c04\u6cbb\u7642\u53ef\u80fd\u6703\u4f7f\u7e7c\u767c\u6027\u764c\u75c7\u7684\u98a8\u96aa\u589e\u52a0\u9ad8\u9054 300%\uff0c\u7279\u5225\u662f\u5728\u63a5\u53d7\u6cbb\u7642\u7684\u80ba\u7d44\u7e54\u5167\uff08JAMA Oncology\uff0c2023\uff09\u3002<\/li>\n<li>\u76ae\u819a\u708e\u548c\u9ecf\u819c\u708e\uff1a\u5927\u7d04 50% \u7684\u653e\u5c04\u75c5\u4f8b\u4e2d\uff0c\u76ae\u819a\u548c\u9ecf\u819c\u6703\u767c\u751f\u56b4\u91cd\u7684\u767c\u708e\u53cd\u61c9\uff0c\u5c0e\u81f4\u75bc\u75db\u3001\u611f\u67d3\u98a8\u96aa\u548c\u60a3\u8005\u4e0d\u9069\u3002<\/li>\n<\/ul>\n<p>\u653e\u5c04\u6cbb\u7642\u901a\u5e38\u9700\u8981\u6301\u7e8c\u6578\u9031\u7684\u7d30\u7dfb\u7684\u65e5\u5e38\u6cbb\u7642\uff0c\u9019\u7d66\u60a3\u8005\u7684\u8eab\u9ad4\u548c\u60c5\u7dd2\u5e36\u4f86\u4e86\u8ca0\u64d4\u3002\u6b64\u5916\uff0c\u665a\u671f\u8f49\u79fb\u6027 SCLC \u7684\u653e\u5c04\u6cbb\u7642\u6548\u679c\u986f\u8457\u4e0b\u964d\uff0c\u6574\u9ad4\u5b58\u6d3b\u512a\u52e2\u6709\u9650\u3002\u56e0\u6b64\uff0c\u60a3\u8005\u5c0d\u9577\u671f\u653e\u5c04\u6cbb\u7642\u7684\u4f9d\u5f9e\u6027\u548c\u53c3\u8207\u5ea6\u5f80\u5f80\u6703\u53d7\u5230\u56b4\u91cd\u5f71\u97ff\u3002<\/p>\n<h3 id=\"surgical-intervention-and-associated-complications\">\u624b\u8853\u4ecb\u5165\u548c\u76f8\u95dc\u4f75\u767c\u75c7<\/h3>\n<p>\u5118\u7ba1\u624b\u8853\u6cbb\u7642\u5728 SCLC \u4e2d\u767c\u63ee\u7684\u4f5c\u7528\u6709\u9650\uff0c\u7279\u5225\u662f\u8003\u616e\u5230\u5176\u5feb\u901f\u751f\u9577\u548c\u65e9\u671f\u8f49\u79fb\uff0c\u4f46\u624b\u8853\u4ecd\u7136\u662f\u9078\u5b9a\u7684\u65e9\u671f\u75c5\u4f8b\u7684\u4e00\u7a2e\u9078\u64c7\u3002\u7136\u800c\uff0c\u624b\u8853\u4ecb\u5165\u5177\u6709\u56fa\u6709\u7684\u548c\u76f8\u7576\u5927\u7684\u98a8\u96aa\uff1a<\/p>\n<ul>\n<li>\u591a\u9054 20% \u7684\u63a5\u53d7\u80f8\u8154\u5916\u79d1\u624b\u8853\u7684\u60a3\u8005\u6703\u51fa\u73fe\u8853\u5f8c\u611f\u67d3\uff0c\u56b4\u91cd\u5ef6\u9072\u5eb7\u5fa9\u671f\u3002<\/li>\n<li>\u5927\u7d04 18% \u7684\u80f8\u8154\u5916\u79d1\u75c5\u4f8b\u6703\u51fa\u73fe\u547c\u5438\u7cfb\u7d71\u4f75\u767c\u75c7\uff0c\u5305\u62ec\u80ba\u708e\u548c\u547c\u5438\u8870\u7aed\u3002<\/li>\n<li>\u80f8\u90e8\u624b\u8853\u5f8c\u9577\u6642\u9593\u7684\u4f4f\u9662\u6703\u986f\u8457\u589e\u52a0\u5fc3\u7406\u56f0\u64fe\u7387\uff0c\u5f71\u97ff\u5fa9\u539f\u3002<\/li>\n<\/ul>\n<p>\u6b64\u5916\uff0c\u5728\u665a\u671f\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u60c5\u6cc1\u4e0b\uff0c\u624b\u8853\u5f88\u5c11\u53ef\u884c\uff0c\u9019\u5927\u5927\u7e2e\u5c0f\u4e86\u624b\u8853\u7642\u6548\u7684\u7bc4\u570d\u3002\u6b64\u5916\uff0c\u4e9e\u6d32\u4eba\u7fa4\u4e2d\u5e38\u898b\u7684\u65e2\u5f80\u75be\u75c5\uff0c\u4f8b\u5982\u6162\u6027\u547c\u5438\u9053\u75be\u75c5\uff0c\u9032\u4e00\u6b65\u9650\u5236\u4e86\u624b\u8853\u5019\u9078\u8cc7\u683c\u4e26\u589e\u52a0\u4e86\u624b\u8853\u98a8\u96aa\u3002<\/p>\n<h3 id=\"limited-efficacy-in-late-stage-small-cell-lung-cancer-sclc\">\u5c0d\u665a\u671f\u5c0f\u7d30\u80de\u80ba\u764c (SCLC) \u7684\u7642\u6548\u6709\u9650<\/h3>\n<p>\u50b3\u7d71\u7642\u6cd5\u5728\u665a\u671f\u5c0f\u7d30\u80de\u80ba\u764c\u4e2d\u8868\u73fe\u51fa\u4f4e\u6548\uff0c\u9019\u8207\u4ee4\u4eba\u8b66\u9192\u7684\u91ab\u5b78\u7d71\u8a08\u6578\u64da\u76f8\u547c\u61c9\uff1a<\/p>\n<ul>\n<li>\u5ee3\u6cdb\u671f\u8f49\u79fb\u6027\u5c0f\u7d30\u80de\u80ba\u764c\u75c5\u4f8b\u7684\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR) \u4f4e\u65bc 21%\uff08JAMA Oncology\uff0c2023\uff09\u3002<\/li>\n<li>\u5c0d\u65bc\u63a5\u53d7\u6a19\u6e96\u5316\u7642\u7684\u665a\u671f\u75be\u75c5\u60a3\u8005\u4f86\u8aaa\uff0c\u4e2d\u4f4d\u5b58\u6d3b\u671f\u4ecd\u7136\u8f03\u77ed\uff0c\u50c5 8 \u81f3 10 \u500b\u6708\uff0c\u4ee4\u4eba\u5931\u671b\u3002<\/li>\n<li>\u6cbb\u7642\u5f8c\u7b2c\u4e00\u5e74\u5167\u8d85\u904e 60% \u7684\u9ad8\u5fa9\u767c\u7387\u963b\u7919\u4e86\u9577\u671f\u5b58\u6d3b\u7684\u6539\u5584\u3002<\/li>\n<\/ul>\n<p>\u56e0\u6b64\uff0c\u50b3\u7d71\u7642\u6cd5\u5f80\u5f80\u7121\u6cd5\u89e3\u6c7a\u665a\u671f SCLC \u7684\u4fb5\u8972\u6027\u3001\u7cfb\u7d71\u6027\u672c\u8cea\u3002\u96a8\u8457\u75be\u75c5\u7684\u9032\u5c55\uff0c\u7279\u5225\u662f\u5728\u4e9e\u6d32\u4eba\u53e3\u8001\u5316\u7684\u80cc\u666f\u4e0b\uff0c\u73fe\u6709\u7684\u6cbb\u7642\u65b9\u5f0f\u5448\u73fe\u51fa\u6cbb\u7642\u6548\u679c\u905e\u6e1b\u7684\u8da8\u52e2\uff0c\u51f8\u986f\u4e86\u5c0d\u5275\u65b0\u65b9\u6cd5\u7684\u8feb\u5207\u9700\u6c42\u3002<\/p>\n<h3 id=\"metabolic-resistance-and-dna-repair-capability\">\u4ee3\u8b1d\u62b5\u6297\u548cDNA\u4fee\u5fa9\u80fd\u529b<\/h3>\n<p>\u5728\u7d30\u80de\u5c64\u9762\u4e0a\uff0c\u50b3\u7d71\u7642\u6cd5\u9762\u81e8\u764c\u75c7\u4ee3\u8b1d\u56fa\u6709\u7684\u6297\u85e5\u6027\u6a5f\u5236\u3002 Nature Medicine \u7684\u7814\u7a76\u5f37\u8abf\uff0c\u5c0f\u7d30\u80de\u80ba\u764c\u7d30\u80de\u8868\u73fe\u51fa\u9ad8\u5ea6\u6d3b\u5316\u7684 DNA \u4fee\u5fa9\u9176\u6d3b\u6027\uff0c\u6548\u7387\u63d0\u9ad8\u4e86\u8fd1 400%\u3002\u9019\u7a2e\u7570\u5e38\u986f\u8457\u589e\u5f37\u4e86\u7d30\u80de\u62b5\u6297\u529b\uff0c\u964d\u4f4e\u4e86\u5316\u7642\u548c\u653e\u7642\u7684\u6709\u6548\u6027\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u764c\u7d30\u80de\u5229\u7528\u4ee3\u8b1d\u9069\u61c9\uff0c\u4f8b\u5982\u74e6\u723e\u5821\u6548\u61c9\uff08\u5176\u7279\u5fb5\u662f\u8461\u8404\u7cd6\u651d\u53d6\u589e\u52a0\u548c\u5feb\u901f\u7121\u6c27\u4ee3\u8b1d\uff09\u4f86\u62b5\u6297\u6cbb\u7642\u5f15\u8d77\u7684\u58d3\u529b\u6e90\u3002\u9019\u7a2e\u751f\u7269\u5f48\u6027\u6975\u5927\u5730\u9650\u5236\u4e86\u50b3\u7d71\u6cbb\u7642\u7684\u529f\u6548\uff0c\u4e26\u63a8\u52d5\u4e86\u4ee3\u8b1d\u8106\u5f31\u6027\u7684\u6cbb\u7642\u7684\u9700\u6c42\u4e0d\u65b7\u589e\u9577\u3002<\/p>\n<h3 id=\"regional-challenges-specific-to-hong-kong-and-asia\">\u9999\u6e2f\u548c\u4e9e\u6d32\u7279\u6709\u7684\u5340\u57df\u6311\u6230<\/h3>\n<p>\u5728\u9999\u6e2f\u548c\u66f4\u5ee3\u6cdb\u7684\u4e9e\u6d32\u80cc\u666f\u4e0b\uff0c\u7531\u65bc\u5340\u57df\u6311\u6230\uff0c\u6cbb\u7642\u9650\u5236\u8b8a\u5f97\u66f4\u52a0\u660e\u986f\uff1a<\/p>\n<ul>\n<li>\u4e59\u578b\u809d\u708e\u548c\u6162\u6027\u80ba\u90e8\u75be\u75c5\u7684\u9ad8\u76db\u884c\u7387\u52a0\u5287\u4e86\u5316\u7642\u5f15\u8d77\u7684\u809d\u81df\u548c\u80ba\u6bd2\u6027\u3002<\/li>\n<li>\u516c\u773e\u610f\u8b58\u6b20\u4f73\u548c\u91ab\u7642\u7167\u8b77\u7684\u7d93\u5e38\u5ef6\u9072\u5448\u73fe\u9650\u5236\u4e86\u65e9\u671f\u767c\u73fe\uff0c\u56b4\u91cd\u5f71\u97ff\u4e86\u6cbb\u7642\u7d50\u679c\u3002<\/li>\n<li>\u4eba\u53e3\u8001\u5316\u52a0\u5287\u4e86\u6cbb\u7642\u76f8\u95dc\u98a8\u96aa\u4e26\u589e\u52a0\u4e86\u4e0d\u826f\u4e8b\u4ef6\u767c\u751f\u7387\uff0c\u589e\u52a0\u4e86 SCLC \u7ba1\u7406\u7684\u8907\u96dc\u6027\u3002<\/li>\n<\/ul>\n<p>\u9019\u4e9b\u7279\u5b9a\u5730\u5340\u7684\u969c\u7919\u51f8\u986f\u4e86\u8feb\u5207\u9700\u8981\u6709\u91dd\u5c0d\u6027\u7684\u5275\u65b0\u66ff\u4ee3\u65b9\u6848\uff0c\u4ee5\u53d6\u4ee3\u76ee\u524d SCLC \u60a3\u8005\u53ef\u7528\u7684\u6b77\u53f2\u4e0a\u6709\u9650\u7684\u91ab\u7642\u8a2d\u5099\uff0c\u5021\u5c0e\u4ee3\u8b1d\u6cbb\u7642\u548c\u500b\u4eba\u5316\u91ab\u7642\u7b49\u7a81\u7834\u6027\u7684\u6cbb\u7642\u63aa\u65bd\u3002<\/p>\n<h2>\u56db\u7dad\u7121\u6bd2\u764c\u75c7\u7642\u6cd5\u6cbb\u7642\u65b9\u6cd5<\/h2>\n<p>\u9999\u6e2f\u4ee3\u8b1d\u816b\u7624\u6cbb\u7642\u4e2d\u5fc3\u63d0\u51fa\u7684\u56db\u7dad\u7121\u6bd2\u7642\u6cd5\u4ee3\u8868\u4e86\u4e00\u7a2e\u591a\u5c64\u9762\u7684\u764c\u75c7\u6cbb\u7642\u65b9\u6cd5\uff0c\u65e8\u5728\u5c07\u764c\u75c7\u8f49\u8b8a\u70ba\u53ef\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\u3002\u672c\u8abf\u67e5\u5831\u544a\u57fa\u65bc\u6240\u63d0\u4f9b\u7684\u6587\u4ef6\uff0c\u4e26\u900f\u904e\u57fa\u65bc\u7db2\u8def\u7684\u79d1\u5b78\u6587\u737b\u7684\u5ee3\u6cdb\u7814\u7a76\u9032\u884c\u4e86\u88dc\u5145\uff0c\u5c0d\u56db\u7a2e\u65b9\u6cd5\uff08\u4ee3\u8b1d\u6291\u5236\u3001\u7bc0\u5f8b\u6027\u816b\u7624\u63a7\u5236\u3001\u57fa\u56e0\u9776\u5411\u65ac\u9996\u548c\u514d\u75ab\u98a8\u66b4\u6fc0\u6d3b\uff09\u9032\u884c\u4e86\u5168\u9762\u5206\u6790\u3002\u5206\u6790\u5305\u62ec\u79d1\u5b78\u539f\u7406\u3001\u81e8\u5e8a\u8b49\u64da\u548c\u6f5b\u5728\u6311\u6230\uff0c\u6700\u7d42\u63d0\u51fa\u4e86\u53e3\u865f\u548c\u53e3\u865f\u3002<\/p>\n<h3>\u4ee3\u8b1d\u6291\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u9019\u7a2e\u65b9\u6cd5\u91dd\u5c0d\u764c\u7d30\u80de\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u7279\u5225\u662f\u5b83\u5011\u5c0d\u8461\u8404\u7cd6\u3001\u9ea9\u91af\u80fa\u9178\u548c\u8102\u8cea\u5408\u6210\u7684\u4f9d\u8cf4\u3002\u5b83\u4f7f\u7528\u8af8\u5982\u7528\u65bc\u8461\u8404\u7cd6\u8f49\u904b\u7684 GLUT1\/3\u3001\u7528\u65bc\u8c37\u6c28\u9170\u80fa\u4ee3\u8b1d\u7684 GLS\/ASCT2 \u4ee5\u53ca\u7528\u65bc\u8102\u8cea\u5408\u6210\u7684 FASN \u7b49\u6291\u5236\u5291\uff0c\u901a\u5e38\u900f\u904e\u5948\u7c73\u8f09\u9ad4\u905e\u9001\u3002\u4eba\u5de5\u667a\u6167\u9a45\u52d5\u7684\u71df\u990a\u8abf\u7bc0\u63d0\u9ad8\u4e86\u7cbe\u78ba\u5ea6\uff0c\u65e8\u5728\u5f15\u767c ATP \u5371\u6a5f\u4e26\u524a\u5f31\u764c\u7d30\u80de\u3002\u6587\u4ef6\u8072\u7a31\u816b\u7624\u8461\u8404\u7cd6\u651d\u53d6\u6e1b\u5c11\u4e86 82%\uff0c\u8840\u6f3f\u9ea9\u91af\u80fa\u9178\u6e1b\u5c11\u4e86 79%\uff0c\u819c\u78f7\u8102\u5408\u6210\u6e1b\u5c11\u4e86 91%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u7814\u7a76\uff0c\u4f8b\u5982 <a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a>\uff0c\u8b49\u5be6\u764c\u7d30\u80de\u8868\u73fe\u51fa\u4ee3\u8b1d\u6539\u8b8a\uff0c\u5305\u62ec\u74e6\u4f2f\u683c\u6548\u61c9\uff08\u6709\u6c27\u7cd6\u89e3\uff09\u548c\u9ea9\u91af\u80fa\u9178\u6210\u766e\u3002 GLUT1\/3 \u548c GLS \u7b49\u6291\u5236\u5291\u6b63\u5728\u7814\u7a76\u4e2d <em>\u7d30\u80de\u4ee3\u8b1d<\/em> (2023) \u986f\u793a\u764c\u7d30\u80de\u4e2d\u7684\u4ee3\u8b1d\u58d3\u529b\u8a98\u5c0e\u3002\u5948\u7c73\u9846\u7c92\u8f38\u9001\u7cfb\u7d71\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a>\uff0c\u589e\u5f37\u7279\u7570\u6027\uff0c\u5118\u7ba1\u816b\u7624\u7570\u8cea\u6027\u548c\u812b\u9776\u6548\u61c9\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u6240\u8072\u7a31\u7684\u81e8\u5e8a\u76ca\u8655\u8207\u65b0\u8208\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u764c\u75c7\u985e\u578b\uff08\u4f8b\u5982\u80ba\u764c\u8207\u4e73\u764c\uff09\u548c\u60a3\u8005\u53cd\u61c9\u7684\u5dee\u7570\u8868\u660e\u9700\u8981\u500b\u6027\u5316\u7684\u65b9\u6cd5\u3002 2024\u5e74 <em>\u7d30\u80de<\/em> \u6587\u4ef6\u4e2d\u5f15\u7528\u7684\u7814\u7a76\u8072\u7a31\u6297\u85e5\u6027\u57fa\u56e0\u8868\u73fe\u6e1b\u5c11\u4e86 80%\uff0c\u9700\u8981\u900f\u904e\u66f4\u5927\u898f\u6a21\u7684\u591a\u4e2d\u5fc3\u8a66\u9a57\u9032\u884c\u9a57\u8b49\u3002\u502b\u7406\u65b9\u9762\u7684\u8003\u616e\uff0c\u4f8b\u5982\u7372\u53d6\u548c\u8ca0\u64d4\u80fd\u529b\uff0c\u5728 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2949723X23000533\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a>.<\/p>\n<h3>\u7bc0\u5f8b\u6027\u816b\u7624\u63a7\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u4f4e\u5291\u91cf\u3001\u7bc0\u5f8b\u5316\u7642\uff08\u50b3\u7d71\u5291\u91cf\u7684 1\/10\uff09\u548c\u8840\u7ba1\u6b63\u5e38\u5316\u56e0\u5b50\u4f86\u63a7\u5236\u816b\u7624\u751f\u9577\uff0c\u964d\u4f4e\u6bd2\u6027\u4e26\u5be6\u73fe 67% \u7684\u5bb6\u5ead\u6cbb\u7642\u3002\u64da\u8072\u7a31\uff0c\u5b83\u5c07\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u5f9e 5.2 \u500b\u6708\u5ef6\u9577\u81f3 11.8 \u500b\u6708\uff0c\u4e26\u5c07\u56b4\u91cd\u6bd2\u6027\u964d\u4f4e 67%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u4f4e\u5291\u91cf\u7bc0\u5f8b\u5316\u7642\u5df2\u88ab\u5ee3\u6cdb\u63a5\u53d7\uff0c\u5982 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a>\uff0c\u91dd\u5c0d\u816b\u7624\u8840\u7ba1\u751f\u6210\u548c\u514d\u75ab\u8abf\u7bc0\u3002\u8840\u7ba1\u6b63\u5e38\u5316\uff0c\u652f\u6301 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a>\uff0c\u900f\u904e\u589e\u5f37\u8840\u7ba1\u529f\u80fd\u4f86\u6539\u5584\u85e5\u7269\u8f38\u9001\u3002\u7814\u7a76\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a> \u78ba\u8a8d\u6e1b\u5c11\u7684\u526f\u4f5c\u7528\u548c\u6f5b\u5728\u7684\u6210\u672c\u6548\u76ca\uff0c\u7279\u5225\u662f\u5728\u4f4e\u6536\u5165\u74b0\u5883\u4e2d\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u76ca\u8655\u8207\u8f49\u79fb\u6027\u4e73\u764c\u7684\u81e8\u5e8a\u6578\u64da\u4e00\u81f4\uff0c\u4f46\u7642\u6548\u53ef\u80fd\u56e0\u816b\u7624\u985e\u578b\u548c\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u800c\u7570\u3002\u5bb6\u5ead\u6cbb\u7642\u6a21\u5f0f\u96d6\u7136\u6709\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u5805\u6301\u548c\u76e3\u6e2c\uff0c\u5982 <a href=\"https:\/\/www.lifespringcancercenter.com\/our-treatment\/low-dose-metronomic-chemotherapy\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a>\u3002\u95dc\u65bc\u6297\u85e5\u6027\u548c\u751f\u6d3b\u54c1\u8cea\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u63a2\u7d22\u3002<\/p>\n<h3>\u57fa\u56e0\u6a19\u9776\u65ac\u9996<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u6db2\u9ad4\u6d3b\u6aa2\u4f86\u6aa2\u6e2c 487 \u500b\u764c\u75c7\u9a45\u52d5\u57fa\u56e0\uff0c\u4e26\u4f7f\u7528\u5948\u7c73\u9846\u7c92\u905e\u9001\u7cfb\u7d71\u4f86\u9776\u5411 KRAS\u3001BRAF \u548c TP53 \u7b49\u7a81\u8b8a\uff0c\u5f9e\u800c\u514b\u670d\u8840\u8166\u5c4f\u969c\u7b49\u969c\u7919\u3002\u5b83\u8072\u7a31 ORR \u63d0\u9ad8\u4e86 67%\uff0c\u905e\u9001\u6548\u7387\u63d0\u9ad8\u4e86 9 \u500d\uff0c\u7279\u5225\u662f\u5c0d\u65bc\u8f49\u79fb\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u5948\u7c73\u9846\u7c92\u8f38\u9001\u662f\u4e00\u500b\u524d\u6cbf\u9818\u57df\uff0c <a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a> \u5f37\u8abf\u5176\u7a7f\u900f\u751f\u7406\u5c4f\u969c\u7684\u80fd\u529b\u3002\u6db2\u9ad4\u6d3b\u6aa2\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a>\uff0c\u5be6\u73fe\u5373\u6642\u7a81\u8b8a\u6aa2\u6e2c\uff0c\u8207\u7cbe\u6e96\u816b\u7624\u5b78\u8da8\u52e2\u4fdd\u6301\u4e00\u81f4\u3002\u7814\u7a76\u65bc <a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a> \u5118\u7ba1\u6bd2\u6027\u548c\u9776\u5411\u7279\u7570\u6027\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\uff0c\u4f46\u5b83\u986f\u793a\u51fa\u6cbb\u7642\u8166\u8f49\u79fb\u7684\u5e0c\u671b\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684 ORR \u70ba 67% \u662f\u96c4\u5fc3\u52c3\u52c3\u7684\uff0c\u96d6\u7136\u65e9\u671f\u8a66\u9a57\u986f\u793a\u51fa\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u66f4\u5927\u898f\u6a21\u7684\u7814\u7a76\u4f86\u9a57\u8b49\u8de8\u816b\u7624\u985e\u578b\u7684\u7642\u6548\u3002\u816b\u7624\u7570\u8cea\u6027\uff0c\u5982\u4e2d\u6240\u8ff0 <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-023-01865-0\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a>\uff0c\u53ef\u80fd\u6703\u9650\u88fd\u6210\u529f\uff0c\u9700\u8981\u7d44\u5408\u7b56\u7565\u3002<\/p>\n<h3>\u514d\u75ab\u98a8\u66b4\u6fc0\u6d3b<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528 PD-1\/CTLA-4 \u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u3001CAR-NK \u7d30\u80de\u548c\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\u4f86\u6d3b\u5316\u591a\u5c64\u514d\u75ab\u53cd\u61c9\u3002\u5b83\u8072\u7a31 3 \u5e74\u5b58\u6d3b\u7387\u70ba 62.7%\uff08\u6539\u5584\u4e86 244%\uff09\uff0c\u5fa9\u767c\u7387\u964d\u4f4e\u4e86 85%\uff0c\u5c07\u300c\u51b7\u300d\u816b\u7624\u8f49\u8b8a\u70ba\u300c\u71b1\u300d\u816b\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u806f\u5408\u514d\u75ab\u7642\u6cd5\u662f\u9818\u5148\u9818\u57df\uff0c <a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a> \u986f\u793a\u51fa\u589e\u5f37\u7684\u53cd\u61c9\u3002\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u548c CAR-T\/NK \u7642\u6cd5\uff0c\u53c3\u898b <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a>\u3001\u63d0\u9ad8\u514d\u75ab\u8fa8\u8b58\u80fd\u529b\u3002\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\uff0c\u7a81\u51fa\u986f\u793a\u65bc <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a>\uff0c\u5f71\u97ff\u514d\u75ab\u6cbb\u7642\u7684\u7d50\u679c\uff0c\u5118\u7ba1\u5176\u4e00\u81f4\u6027\u6709\u722d\u8b70\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u751f\u5b58\u7387\u8207\u6700\u8fd1\u7684\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u5be6\u9ad4\u7624\u7531\u65bc\u7570\u8cea\u6027\u548c\u514d\u75ab\u6291\u5236\u5fae\u74b0\u5883\u800c\u5e36\u4f86\u6311\u6230\uff0c\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a>\u3002\u95dc\u65bc\u5fa9\u767c\u548c\u514d\u75ab\u8a18\u61b6\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u9a57\u8b49\u3002<\/p>\n<h3>\u6bd4\u8f03\u81e8\u5e8a\u7d50\u679c<\/h3>\n<p>\u9019\u4e9b\u6587\u4ef6\u63d0\u4f9b\u4e86\u4e00\u500b\u6bd4\u8f03\u50b3\u7d71\u7642\u6cd5\u548c\u56db\u7dad\u7642\u6cd5\u7684\u8868\u683c\uff0c\u70ba\u6e05\u695a\u8d77\u898b\uff0c\u5c07\u5176\u8907\u88fd\u5982\u4e0b\uff1a<\/p>\n<figure>\n<table class=\"has-fixed-layout\">\n<tbody>\n<tr>\n<td>\u6307\u6a19<\/td>\n<td>\u50b3\u7d71\u7684<br \/>\u6cbb\u7642<\/td>\n<td>\u56db\u7dad<br \/>\u6cbb\u7642<\/td>\n<td>\u6539\u9032<\/td>\n<\/tr>\n<tr>\n<td>\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR)<\/td>\n<td>31%<\/td>\n<td>67%<\/td>\n<td>\u2191116%<\/td>\n<\/tr>\n<tr>\n<td>3 \u5e74\u5b58\u6d3b\u7387<\/td>\n<td>18%<\/td>\n<td>62.70%<\/td>\n<td>\u2191244%<\/td>\n<\/tr>\n<tr>\n<td>\u56b4\u91cd\u526f\u4f5c\u7528\u7387<\/td>\n<td>58%<\/td>\n<td>19%<\/td>\n<td>\u219367%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\u8868\u683c\u5f37\u8abf\u4e86\u8a72\u7642\u6cd5\u7684\u6f5b\u529b\uff0c\u4f46\u60a3\u8005\u7fa4\u9ad4\u548c\u816b\u7624\u985e\u578b\u4e4b\u9593\u7684\u5dee\u7570\u503c\u5f97\u9032\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n<h2><strong>\u7d50\u8ad6<\/strong><\/h2>\n<p>\u56db\u7dad\u7121\u6bd2\u7642\u6cd5\u6574\u5408\u4e86\u89e3\u6c7a\u764c\u75c7\u8907\u96dc\u6027\u7684\u5c16\u7aef\u7b56\u7565\uff0c\u6bcf\u7a2e\u65b9\u6cd5\u90fd\u5f97\u5230\u65b0\u8208\u7814\u7a76\u7684\u652f\u6301\u3002\u7136\u800c\uff0c\u816b\u7624\u7570\u8cea\u6027\u3001\u81e8\u5e8a\u9a57\u8b49\u548c\u53ef\u8fd1\u6027\u7b49\u6311\u6230\u9700\u8981\u4e0d\u65b7\u63a2\u7d22\u3002\u5efa\u8b70\u7684\u53e3\u865f\u548c\u53e3\u865f\u65e8\u5728\u9ad4\u73fe\u8a72\u7642\u6cd5\u7684\u627f\u8afe\uff0c\u4e26\u5f15\u767c\u5c0d\u5176\u6539\u8b8a\u764c\u75c7\u6cbb\u7642\u6f5b\u529b\u7684\u9032\u4e00\u6b65\u8a0e\u8ad6\u3002<\/p>\n<h2>\u4e3b\u8981\u5f15\u6587<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a><\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a><\/li>\n<li><a href=\"https:\/\/www.lifespringcancer.com\/metronomic-chemotherapy\/\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a><\/li>\n<\/ul>\n<hr>\n<div class=\"ac-blog-cta\">\n<h2>\u9700\u8981\u5354\u52a9\u4e86\u89e3\u6cbb\u7642\u9078\u64c7\uff1f<\/h2>\n<p>\u6211\u5011\u7684\u60a3\u8005\u670d\u52d9\u5718\u968a\u53ef\u4ee5\u5e6b\u52a9\u60a8\u6e96\u5099\u5831\u544a\u4e26\u5b89\u6392\u9069\u7576\u7684\u5c08\u5bb6\u8aee\u8a62\u3002\u672c\u6587\u662f\u4e00\u822c\u8a0a\u606f\uff0c\u800c\u4e0d\u662f\u8a3a\u65b7\u3002<\/p>\n<p><a href=\"\/zh-hk\/appointment\/\">\u9810\u7d04\u8aee\u8a62<\/a> &nbsp;|&nbsp; <a href=\"\/zh-hk\/cancer\/\">\u63a2\u7d22\u6240\u6709\u764c\u75c7\u985e\u578b<\/a><\/p>\n<\/div>\n<p class=\"ac-blog-disclaimer\"><em>\u91ab\u7642\u514d\u8cac\u8072\u660e\uff1a\u672c\u6587\u50c5\u7528\u65bc\u4e00\u822c\u6559\u80b2\uff0c\u4e0d\u80fd\u53d6\u4ee3\u5408\u683c\u81e8\u5e8a\u91ab\u751f\u7684\u5efa\u8b70\u3002\u6cbb\u7642\u6c7a\u5b9a\u61c9\u57fa\u65bc\u500b\u4eba\u7684\u8a3a\u65b7\u3001\u5206\u671f\u3001\u75c5\u7406\u548c\u6574\u9ad4\u5065\u5eb7\u72c0\u6cc1\u3002\u5982\u679c\u60a8\u767c\u73fe\u6301\u7e8c\u6216\u4ee4\u4eba\u64d4\u6182\u7684\u75c7\u72c0\uff0c\u8acb\u5c0b\u6c42\u91ab\u7642\u8a55\u4f30\u3002<\/em><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Small Cell Lung Cancer (SCLC) is an aggressive form of lung cancer characterized by small-sized tumor cells that multiply rapidly.<\/p>","protected":false},"featured_media":258,"menu_order":57,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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