{"id":383,"date":"2026-06-20T09:00:00","date_gmt":"2026-06-20T09:00:00","guid":{"rendered":"https:\/\/all-cancers.com\/cancer\/primary-peritoneal-cancer-primary-peritoneal-carcinoma-cacner\/"},"modified":"2026-10-29T13:38:07","modified_gmt":"2026-10-29T13:38:07","slug":"primary-peritoneal-cancer-primary-peritoneal-carcinoma-cacner","status":"publish","type":"cancer_type","link":"https:\/\/all-cancers.com\/zh-hk\/cancer\/primary-peritoneal-cancer-primary-peritoneal-carcinoma-cacner\/","title":{"rendered":"\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09"},"content":{"rendered":"<div class=\"ac-blog-article\">\n<p class=\"ac-blog-lead\"><strong>\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09\u662f\u4e00\u7a2e\u8d77\u6e90\u65bc\u8179\u819c\uff08\u8986\u84cb\u8179\u90e8\u5668\u5b98\u7684\u8584\u5c64\uff09\u7684\u7f55\u898b\u60e1\u6027\u816b\u7624\u3002\u9019\u7a2e\u764c\u75c7\u5728\u751f\u7269\u5b78\u4e0a\u8207\u5375\u5de2\u764c\u76f8\u4f3c\uff0c\u4e3b\u8981\u5f71\u97ff\u5973\u6027\uff0c\u4f46\u4e5f\u5f88\u5c11\u5f71\u97ff\u7537\u6027\u3002\u8207\u5176\u4ed6\u60e1\u6027\u816b\u7624\u4e00\u6a23\uff0c\u539f\u767c\u6027\u8179\u819c\u764c\u8868\u73fe\u51fa\u5c0d\u7279\u5b9a\u4ee3\u8b1d\u9014\u5f91\u7684\u9ad8\u5ea6\u4f9d\u8cf4\u6027\uff0c\u5c24\u5176\u662f\u8461\u8404\u7cd6\u4ee3\u8b1d\uff08\u7a31\u70ba\u74e6\u4f2f\u683c\u6548\u61c9\uff09\uff0c\u764c\u7d30\u80de\u6d88\u8017\u8461\u8404\u7cd6\u7684\u901f\u5ea6\u7d04\u70ba\u5178\u578b\u901f\u7387\u7684 200 \u500d\uff0c\u5f9e\u800c\u4fc3\u9032\u7d30\u80de\u5feb\u901f\u589e\u6b96\u3002<\/strong><\/p>\n<nav class=\"ac-blog-toc\" aria-label=\"\u672c\u6587\u5c0e\u89bd\">\n<p><strong>\u672c\u6587\u5c0e\u89bd<\/strong><\/p>\n<ul>\n<li><a href=\"#what-is-primary-peritoneal-cancer-primary-peritoneal-carcinoma\">\u4ec0\u9ebc\u662f\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09\uff1f<\/a><\/li>\n<li><a href=\"#causes-and-risk-factors-of-primary-peritoneal-cancer-primary-peritoneal-carcinom\">\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09\u7684\u75c5\u56e0\u8207\u5371\u96aa\u56e0\u5b50<\/a><\/li>\n<li><a href=\"#symptoms-of-primary-peritoneal-cancer-primary-peritoneal-carcinoma\">\u539f\u767c\u6027\u8179\u819c\u764c\u7684\u75c7\u72c0\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09<\/a><\/li>\n<li><a href=\"#stages-of-primary-peritoneal-cancer-primary-peritoneal-carcinoma-and-survival-ra\">\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09\u7684\u5206\u671f\u8207\u5b58\u6d3b\u7387<\/a><\/li>\n<li><a href=\"#limitations-of-traditional-therapies-for-primary-peritoneal-cancer-primary-perit\">\u539f\u767c\u6027\u8179\u819c\u764c\u50b3\u7d71\u7642\u6cd5\u7684\u9650\u5236\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09<\/a><\/li>\n<\/ul>\n<\/nav>\n<h2 id=\"what-is-primary-peritoneal-cancer-primary-peritoneal-carcinoma\">\u4ec0\u9ebc\u662f <strong>\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09<\/strong>?<\/h2>\n<p>\u56e0\u6b64\uff0c\u4e86\u89e3\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09\u6d89\u53ca\u6aa2\u67e5\u9019\u7a2e\u4ee3\u8b1d\u7570\u5e38\uff0c\u5f9e\u800c\u5be6\u73fe\u65e8\u5728\u7834\u58de\u816b\u7624\u6709\u6548\u8461\u8404\u7cd6\u651d\u53d6\u548c\u7121\u6c27\u7cd6\u9175\u89e3\u7684\u6a19\u9776\u4ee3\u8b1d\u7642\u6cd5\u3002\u6b64\u5916\uff0c\u8a79\u59c6\u65af\u00b7\u827e\u5229\u68ee\u535a\u58eb\u548c\u683c\u96f7\u683c\u00b7\u585e\u9580\u624e\u535a\u58eb\u7b49\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u9032\u884c\u7684\u7814\u7a76\u5f37\u8abf\u4e86\u91dd\u5c0d\u4ee3\u8b1d\u8106\u5f31\u6027\u4ee5\u63d0\u9ad8\u764c\u75c7\u6cbb\u7642\u6548\u679c\u7684\u91cd\u8981\u6027\u3002<\/p>\n<p>\u6839\u64da\u4e16\u754c\u885b\u751f\u7d44\u7e54 (WHO, 2024) \u7684\u6578\u64da\uff0c\u539f\u767c\u6027\u8179\u819c\u764c\u96d6\u7136\u5728\u5168\u7403\u7bc4\u570d\u5167\u5f88\u5c11\u898b\uff0c\u4f46\u6bcf\u5e74\u6bcf 10 \u842c\u540d\u5973\u6027\u4e2d\u7d04\u6709 4 \u540d\u60a3\u8005\u53d7\u5230\u539f\u767c\u6027\u8179\u819c\u764c\u7684\u5f71\u97ff\u3002\u5728\u4e9e\u6d32\u5730\u5340\uff0c\u5305\u62ec\u9999\u6e2f\u7b49\u5730\u5340\uff0c\u8179\u819c\u764c\u7684\u767c\u751f\u7387\u5448\u4e0a\u5347\u8da8\u52e2\uff0c\u90e8\u5206\u539f\u56e0\u8207\u4eba\u53e3\u8001\u5316\u548c\u751f\u6d3b\u65b9\u5f0f\u7684\u6539\u8b8a\u6709\u95dc\u3002<\/p>\n<p>\u539f\u767c\u6027\u8179\u819c\u764c\u986f\u8457\u5f71\u97ff\u751f\u6d3b\u8cea\u91cf\uff0c\u7d93\u5e38\u5f15\u8d77\u8eab\u9ad4\u75bc\u75db\u3001\u8179\u8139\u3001\u8179\u90e8\u816b\u8139\u548c\u75b2\u52de\uff0c\u540c\u6642\u7d66\u60a3\u8005\u5e36\u4f86\u58d3\u529b\u3001\u7126\u616e\u548c\u6182\u9b31\u7684\u60c5\u7dd2\u8ca0\u64d4\u3002\u65e9\u671f\u8a3a\u65b7\u548c\u4ecb\u5165\u53ef\u4ee5\u6975\u5927\u5730\u5f71\u97ff\u9810\u5f8c\uff0c\u5f37\u8abf\u4e86\u89e3\u65e9\u671f\u75c7\u72c0\u4e26\u53ca\u6642\u5230 AllCancer \u7b49\u5c08\u696d\u6a5f\u69cb\u5c0b\u6c42\u91ab\u7642\u8aee\u8a62\u7684\u91cd\u8981\u6027\u3002<\/p>\n<ul>\n<li>\u75c7\u72c0\u5305\u62ec\u8179\u75db\u548c\u8179\u8139<\/li>\n<li>\u98df\u617e\u4e0d\u632f\u548c\u5641\u5fc3<\/li>\n<li>\u7121\u6cd5\u89e3\u91cb\u7684\u9ad4\u91cd\u8b8a\u5316\u548c\u75b2\u52de<\/li>\n<li>\u6d88\u5316\u4e0d\u826f\u4e0d\u9069<\/li>\n<\/ul>\n<p>\u4e86\u89e3\u6709\u95dc AllCancer \u63d0\u4f9b\u7684\u5148\u9032\u764c\u75c7\u8a3a\u65b7\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u4ee5\u53ca\u65e9\u671f\u6aa2\u6e2c\u5982\u4f55\u986f\u8457\u63d0\u9ad8\u6709\u6548\u7ba1\u7406\u3002<\/p>\n<h3 id=\"understanding-primary-peritoneal-cancer-metabolic-vulnerabilities\">\u4e86\u89e3\u539f\u767c\u6027\u8179\u819c\u764c\u548c\u4ee3\u8b1d\u8106\u5f31\u6027<\/h3>\n<p>\u5373\u4f7f\u5728\u5bcc\u6c27\u689d\u4ef6\u4e0b\uff0c\u8868\u73fe\u51fa\u74e6\u723e\u5821\u6548\u61c9\u7684\u764c\u7d30\u80de\u4e5f\u6703\u512a\u5148\u900f\u904e\u7cd6\u89e3\u4f5c\u7528\u5229\u7528\u8461\u8404\u7cd6\uff0c\u9019\u8207\u6b63\u5e38\u7684\u7d30\u80de\u4ee3\u8b1d\u622a\u7136\u4e0d\u540c\u3002\u9019\u7a2e\u4e0d\u5c0b\u5e38\u7684\u504f\u597d\u4f7f\u764c\u7d30\u80de\u80fd\u5920\u5feb\u901f\u589e\u6b96\uff0c\u652f\u6301\u5b83\u5011\u7684\u9ad8\u80fd\u91cf\u9700\u6c42\u4e26\u63d0\u4f9b\u8207\u764c\u75c7\u767c\u751f\u5bc6\u5207\u76f8\u95dc\u7684\u95dc\u9375\u751f\u7269\u5408\u6210\u524d\u9ad4\u3002<\/p>\n<p>\u9664\u4e86\u8461\u8404\u7cd6\u4e4b\u5916\uff0c\u764c\u7d30\u80de\u9084\u8868\u73fe\u51fa\u5c0d\u8c37\u6c28\u9170\u80fa\u4ee3\u8b1d\u7684\u660e\u986f\u4f9d\u8cf4\u6027\uff0c\u9019\u7a2e\u6c28\u57fa\u9178\u4e3b\u8981\u7528\u65bc\u5408\u6210\u6838\u82f7\u9178\u548c\u7dad\u6301\u7d30\u80de\u6c27\u5316\u9084\u539f\u5e73\u8861\u3002\u5927\u7d04 50% \u7684\u764c\u7d30\u80de\uff0c\u5305\u62ec\u539f\u767c\u6027\u8179\u819c\u764c\u7d30\u80de\uff0c\u8868\u73fe\u51fa\u8f03\u9ad8\u7684\u9ea9\u91af\u80fa\u9178\u4f9d\u8cf4\u6027\uff0c\u7a81\u986f\u4e86\u6cbb\u7642\u4e0a\u53ef\u5229\u7528\u7684\u8106\u5f31\u6027\u3002<\/p>\n<p>\u674e\u570b\u83ef\u535a\u58eb\u548c\u5289\u570b\u9f8d\u6559\u6388\u7684\u958b\u5275\u6027\u7814\u7a76\u5fb9\u5e95\u6539\u8b8a\u4e86\u5168\u7403\u4ee3\u8b1d\u764c\u75c7\u6cbb\u7642\u65b9\u6cd5\uff0c\u5f37\u8abf\u4e86\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d\u4ee5\u7372\u5f97\u6cbb\u7642\u6548\u679c\u7684\u81e8\u5e8a\u610f\u7fa9\u3002 AllCancer \u64c1\u62b1\u9019\u4e9b\u7814\u7a76\u898b\u89e3\uff0c\u63d0\u4f9b\u5275\u65b0\u7684\u4ee3\u8b1d\u816b\u7624\u7642\u6cd5\uff0c\u53ef\u986f\u8457\u63d0\u9ad8\u5b58\u6d3b\u7d50\u679c\u3002<\/p>\n<p>\u4e86\u89e3 AllCancer \u958b\u767c\u7684\u4ee3\u8b1d\u7642\u6cd5\u5982\u4f55\u6539\u5584\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u3002\u5982\u9700\u8a73\u7d30\u8aee\u8a62\u548c\u5c08\u5bb6\u5efa\u8b70\uff0c\u8acb\u7acb\u5373\u806f\u7d61\u6211\u5011\u7684\u81e8\u5e8a\u91ab\u751f\u3002<\/p>\n<h2 id=\"causes-and-risk-factors-of-primary-peritoneal-cancer-primary-peritoneal-carcinom\">\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09\u7684\u75c5\u56e0\u8207\u5371\u96aa\u56e0\u5b50<\/h2>\n<p>\u4e86\u89e3\u539f\u767c\u6027\u8179\u819c\u764c\u7684\u5371\u96aa\u56e0\u5b50\u5c0d\u65bc\u4fc3\u9032\u65e9\u671f\u767c\u73fe\u548c\u53ca\u6642\u4ecb\u5165\u81f3\u95dc\u91cd\u8981\u3002\u96d6\u7136\u78ba\u5207\u539f\u56e0\u5c1a\u4e0d\u6e05\u695a\uff0c\u4f46\u5e7e\u500b\u5bc6\u5207\u76f8\u95dc\u7684\u98a8\u96aa\u56e0\u7d20\u63d0\u4f9b\u4e86\u6709\u50f9\u503c\u7684\u9810\u9632\u898b\u89e3\u3002<\/p>\n<h3 id=\"genetic-factors\">\u907a\u50b3\u56e0\u7d20<\/h3>\n<p>BRCA1 \u548c BRCA2 \u7684\u907a\u50b3\u6027\u57fa\u56e0\u7a81\u8b8a\u6703\u986f\u8457\u589e\u52a0\u5973\u6027\u7f79\u60a3\u8179\u819c\u764c\u548c\u5375\u5de2\u764c\u7684\u98a8\u96aa\u3002\u7d71\u8a08\u6578\u64da\u8868\u660e\uff0c\u8207\u4e00\u822c\u4eba\u7fa4\u76f8\u6bd4\uff0cBRCA \u7a81\u8b8a\u651c\u5e36\u8005\u4e00\u751f\u4e2d\u60a3\u539f\u767c\u6027\u8179\u819c\u764c\u7684\u98a8\u96aa\u9ad8\u9054 40-60%\u3002<\/p>\n<ul>\n<li>BRCA1\u7a81\u8b8a<br \/>\n\uff0855-65% \u7d42\u751f\u5375\u5de2\/\u8179\u819c\u98a8\u96aa\uff09<\/li>\n<li>BRCA2\u7a81\u8b8a<br \/>\n\uff0810-25% \u7d42\u751f\u5375\u5de2\/\u8179\u819c\u98a8\u96aa\uff09<\/li>\n<\/ul>\n<p>\u6b64\u5916\uff0c\u5176\u4ed6\u5375\u5de2\u764c\u76f8\u95dc\u57fa\u56e0\uff08\u5982 RAD51C\/RAD51D\u3001PALB2 \u548c\u6797\u5947\u75c7\u5019\u7fa4\u76f8\u95dc\u7684 MLH1 \u6216 MSH2\uff09\u7684\u7a81\u8b8a\u9032\u4e00\u6b65\u589e\u52a0\u764c\u75c7\u6613\u611f\u6027\uff0c\u5f37\u8abf\u65e9\u671f\u57fa\u56e0\u7be9\u6aa2\u7684\u7dca\u8feb\u6027\u3002<\/p>\n<h3 id=\"environmental-factors\">\u74b0\u5883\u56e0\u7d20<\/h3>\n<p>\u63a5\u89f8\u74b0\u5883\u81f4\u764c\u7269\u548c\u67d0\u4e9b\u91ab\u5b78\u6cbb\u7642\uff08\u5316\u7642\u548c\u653e\u5c04\u6cbb\u7642\uff09\u6703\u52a0\u5287\u7d30\u80de\u8b8a\u5316\uff0c\u5f9e\u800c\u63d0\u9ad8\u8179\u819c\u764c\u7684\u98a8\u96aa\u3002\u5118\u7ba1\u8207\u5176\u4ed6\u764c\u75c7\u76f8\u6bd4\uff0c\u5176\u5b9a\u7fa9\u8f03\u5c11\uff0c\u4f46\u6b64\u985e\u74b0\u5883\u66b4\u9732\u9700\u8981\u63d0\u9ad8\u610f\u8b58\u548c\u8b66\u89ba\u6027\u3002<\/p>\n<h3 id=\"lifestyle-and-metabolic-risk-factors\">\u751f\u6d3b\u65b9\u5f0f\u548c\u4ee3\u8b1d\u98a8\u96aa\u56e0\u7d20<\/h3>\n<p>\u80a5\u80d6\u5728\u5305\u62ec\u9999\u6e2f\u5728\u5167\u7684\u4e9e\u6d32\u65e5\u76ca\u6d41\u884c\uff0c\u5b83\u6703\u4fc3\u9032\u6162\u6027\u767c\u708e\u548c\u8377\u723e\u8499\u7d0a\u4e82\uff0c\u5f9e\u800c\u986f\u8457\u589e\u52a0\u764c\u75c7\u98a8\u96aa\u3002\u7814\u7a76\u5c07\u80a5\u80d6\u8207\u80f0\u5cf6\u7d20\u963b\u6297\u52a0\u5287\u548c\u985e\u80f0\u5cf6\u7d20\u751f\u9577\u56e0\u5b50\u6c34\u5e73\u5347\u9ad8\u806f\u7e6b\u8d77\u4f86\uff0c\u5169\u8005\u90fd\u6709\u5229\u65bc\u764c\u7d30\u80de\u589e\u6b96\u3002<\/p>\n<ul>\n<li>\u80a5\u80d6\u5f15\u8d77\u7684\u6162\u6027\u767c\u708e\u548c\u8377\u723e\u8499\u5931\u8861<\/li>\n<li>\u4e45\u5750\u7684\u751f\u6d3b\u65b9\u5f0f\u6703\u589e\u52a0\u4ee3\u8b1d\u75c7\u5019\u7fa4\u7684\u98a8\u96aa<\/li>\n<li>\u9ad8\u8102\u80aa\u548c\u9ad8\u7cd6\u98f2\u98df\u6703\u52a0\u5287\u4ee3\u8b1d\u5931\u8861<\/li>\n<\/ul>\n<p>\u89e3\u6c7a\u4ee3\u8b1d\u8106\u5f31\u6027\u662f AllCancer \u5275\u65b0\u6cbb\u7642\u7684\u91cd\u9ede\uff0c\u5176\u4e2d\u5c08\u9580\u7684\u4ee3\u8b1d\u7642\u6cd5\u5c08\u9580\u7834\u58de\u8207\u764c\u75c7\u76f8\u95dc\u7684\u4ee3\u8b1d\u9014\u5f91\uff0c\u76f4\u63a5\u91dd\u5c0d\u8461\u8404\u7cd6\u548c\u8c37\u6c28\u9170\u80fa\u4ee3\u8b1d\u3002<\/p>\n<h3 id=\"asian-specific-risks\">\u4e9e\u6d32\u7279\u6709\u7684\u98a8\u96aa<\/h3>\n<p>\u9999\u6e2f\u548c\u6574\u500b\u4e9e\u6d32\u5730\u5340\u7684\u7279\u5b9a\u98a8\u96aa\u5305\u62ec\u907a\u50b3\u50be\u5411\u548c\u98f2\u98df\u7fd2\u6163\uff0c\u4f8b\u5982\u5927\u91cf\u98df\u7528\u52a0\u5de5\u98df\u54c1\uff0c\u5c0e\u81f4\u8207\u80a5\u80d6\u76f8\u95dc\u7684\u764c\u75c7\uff08\u5305\u62ec\u539f\u767c\u6027\u8179\u819c\u764c\uff09\u7684\u767c\u75c5\u7387\u5347\u9ad8\u3002<\/p>\n<p>\u65e9\u671f\u7be9\u6aa2\uff0c\u7279\u5225\u662f\u5728\u907a\u50b3\u6613\u611f\u4eba\u7fa4\u4e2d\u548c\u7a4d\u6975\u6539\u8b8a\u751f\u6d3b\u65b9\u5f0f\uff0c\u53ef\u4ee5\u5927\u5927\u964d\u4f4e\u8179\u819c\u764c\u7684\u98a8\u96aa\u3002 AllCancer\u5f37\u8abf\u5168\u9762\u7684\u57fa\u56e0\u7be9\u6aa2\u548c\u751f\u6d3b\u65b9\u5f0f\u8a55\u4f30\uff0c\u4ee5\u5728\u65e9\u671f\u767c\u73fe\u5371\u96aa\u56e0\u7d20\uff0c\u900f\u904e\u53ca\u6642\u7684\u9810\u9632\u5e72\u9810\u63aa\u65bd\u6539\u5584\u9810\u5f8c\u3002<\/p>\n<p>\u63a7\u5236\u60a8\u7684\u764c\u75c7\u98a8\u96aa\u3002\u7acb\u5373\u900f\u904e AllCancer \u5b89\u6392\u60a8\u7684\u57fa\u56e0\u7be9\u6aa2\u548c\u751f\u6d3b\u578b\u614b\u98a8\u96aa\u8a55\u4f30\u3002<\/p>\n<h2 id=\"symptoms-of-primary-peritoneal-cancer-primary-peritoneal-carcinoma\">\u539f\u767c\u6027\u8179\u819c\u764c\u7684\u75c7\u72c0\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09<\/h2>\n<p>\u53ca\u65e9\u8b58\u5225\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09\u53ef\u5927\u5e45\u6539\u5584\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u548c\u751f\u6d3b\u54c1\u8cea\u3002\u75c7\u72c0\u6700\u521d\u53ef\u80fd\u5f88\u5fae\u5999\u4e14\u975e\u7279\u7570\u6027\uff0c\u56e0\u6b64\u65e9\u671f\u8b58\u5225\u81f3\u95dc\u91cd\u8981\u3002\u4ee5\u4e0b\u662f\u60a3\u8005\u7d93\u5e38\u7d93\u6b77\u7684\u5e38\u898b\u548c\u7279\u5b9a\u968e\u6bb5\u7684\u75c7\u72c0\uff1a<\/p>\n<h3 id=\"common-symptoms-of-primary-peritoneal-cancer-primary-peritoneal-carcinoma\">\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09\u7684\u5e38\u898b\u75c7\u72c0<\/h3>\n<ul>\n<li>\u8179\u8139\u548c\u8179\u90e8\u4e0d\u9069\u5e38\u88ab\u8aa4\u8a8d\u70ba\u662f\u6d88\u5316\u7cfb\u7d71\u75be\u75c5<\/li>\n<li>\u8179\u570d\u589e\u52a0\u6216\u8179\u6c34\u816b\u8139\uff08\u7a4d\u6db2\uff09<\/li>\n<li>\u6392\u4fbf\u7fd2\u6163\u6539\u8b8a\uff0c\u4f8b\u5982\u6301\u7e8c\u6027\u4fbf\u79d8\u6216\u8179\u7009<\/li>\n<li>\u65e9\u98fd\u6216\u98ef\u5f8c\u5f88\u5feb\u5c31\u611f\u5230\u98fd<\/li>\n<li>\u6a21\u7cca\u7684\u9aa8\u76c6\u6216\u8179\u90e8\u75bc\u75db<\/li>\n<li>\u5118\u7ba1\u98df\u617e\u7dad\u6301\u6b63\u5e38\uff0c\u4f46\u9ad4\u91cd\u537b\u51fa\u73fe\u4e0d\u660e\u539f\u56e0\u7684\u6e1b\u8f15<\/li>\n<li>\u6162\u6027\u75b2\u52de\u548c\u865b\u5f31\u53ef\u80fd\u8207\u816b\u7624\u4ee3\u8b1d\u9700\u6c42\u6709\u95dc<\/li>\n<li>\u5641\u5fc3\u3001\u5076\u723e\u5614\u5410\u548c\u6d88\u5316\u554f\u984c<\/li>\n<li>\u96a8\u8457\u6642\u9593\u7684\u63a8\u79fb\uff0c\u98df\u617e\u4e0d\u632f\u6703\u5f71\u97ff\u71df\u990a\u72c0\u6cc1<\/li>\n<\/ul>\n<p>\u75c7\u72c0\u56e0\u816b\u7624\u5927\u5c0f\u548c\u4f4d\u7f6e\u800c\u7570\uff0c\u53cd\u6620\u4e86\u75be\u75c5\u4e0d\u65b7\u8b8a\u5316\u7684\u751f\u7269\u5b78\u7279\u6027\u3002\u816b\u7624\u76f8\u95dc\u7684\u58d3\u529b\u548c\u6db2\u9ad4\u901a\u9053\uff08\u6dcb\u5df4\u7ba1\u3001\u975c\u8108\uff09\u7684\u963b\u585e\u5c0e\u81f4\u6db2\u9ad4\u7a4d\u805a\u548c\u96a8\u5f8c\u7684\u75c7\u72c0\u3002\u764c\u7d30\u80de\u9ad8\u7cd6\u4ee3\u8b1d\uff08\u74e6\u723e\u5821\u6548\u61c9\uff09\u4e5f\u6703\u5c0e\u81f4\u5168\u8eab\u75b2\u52de\u548c\u865b\u5f31\u3002<\/p>\n<h3 id=\"stage-related-symptom-variations\">\u968e\u6bb5\u76f8\u95dc\u75c7\u72c0\u8b8a\u7570<\/h3>\n<ul>\n<li><strong>\u65e9\u671f\u968e\u6bb5<\/strong>\n<ul>\n<li>\u8f15\u5ea6\u8179\u8139\u6216\u4e0d\u9069\u5e38\u8207\u6d88\u5316\u7cfb\u7d71\u75be\u75c5\u6df7\u6dc6<\/li>\n<li>\u9593\u6b47\u6027\u6d88\u5316\u554f\u984c\u548c\u975e\u7279\u7570\u6027\u9aa8\u76c6\u4e0d\u9069<\/li>\n<\/ul>\n<\/li>\n<li><strong>\u5f8c\u671f\uff08III\/IV \u671f\uff09<\/strong>\n<ul>\n<li>\u7531\u65bc\u5927\u91cf\u8179\u6c34\u800c\u5c0e\u81f4\u8179\u90e8\u56b4\u91cd\u4e14\u660e\u986f\u816b\u8139<\/li>\n<li>\u7531\u65bc\u5ee3\u6cdb\u7684\u8179\u819c\u53d7\u7d2f\u548c\u5668\u5b98\u53d7\u58d3\u800c\u5c0e\u81f4\u5c40\u90e8\u5287\u70c8\u75bc\u75db<\/li>\n<li>\u5168\u8eab\u75c7\u72c0\uff0c\u5982\u4e0d\u660e\u539f\u56e0\u7684\u9ad4\u91cd\u6e1b\u8f15\u3001\u75b2\u52de\u548c\u53ad\u98df\uff0c\u56e0\u764c\u75c7\u5728\u8179\u90e8\u548c\u9aa8\u76c6\u7684\u64f4\u6563\u800c\u52a0\u5287<\/li>\n<li>\u8179\u6c34\u5f15\u8d77\u7684\u5916\u5728\u6a6b\u8188\u819c\u58d3\u529b\u5c0e\u81f4\u547c\u5438\u7a98\u8feb\u52a0\u5287<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\u6839\u64da\u5289\u570b\u9f8d\u6559\u6388\u7b49\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u548c\u5c0a\u656c\u7684\u540c\u4e8b\u7684\u5c08\u5bb6\u5efa\u8b70\uff0c\u65e9\u671f\u8b58\u5225\u3001\u91ab\u5b78\u8a55\u4f30\u548c\u6a19\u9776\u4ee3\u8b1d\u6cbb\u7642\u8a3a\u65b7\u5c0d\u65bc\u6539\u5584\u9810\u5f8c\u548c\u6cbb\u7642\u6548\u679c\u81f3\u95dc\u91cd\u8981\u3002\u65e9\u671f\u75c7\u72c0\u8b58\u5225\u8207\u63d0\u9ad8\u5b58\u6d3b\u7387\u4ee5\u53ca\u5c0d\u6df1\u5733\u524d\u6d77\u6cf0\u5eb7\u548c MD \u5b89\u5fb7\u68ee\u7b49\u5408\u4f5c\u4e2d\u5fc3\u7684 4D \u7642\u6cd5\u7b49\u6cbb\u7642\u7684\u53cd\u61c9\u986f\u8457\u76f8\u95dc\u3002<\/p>\n<h2 id=\"stages-of-primary-peritoneal-cancer-primary-peritoneal-carcinoma-and-survival-ra\">\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09\u7684\u5206\u671f\u8207\u5b58\u6d3b\u7387<\/h2>\n<p>\u4e86\u89e3\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09\u7684\u4e0d\u540c\u968e\u6bb5\u6709\u52a9\u65bc\u53ca\u6642\u4ecb\u5165\u548c\u500b\u4eba\u5316\u6cbb\u7642\u65b9\u6cd5\u3002\u5728\u9019\u88e1\uff0c\u6211\u5011\u56de\u9867\u6bcf\u500b\u968e\u6bb5\u3001\u76f8\u61c9\u7684\u7279\u5fb5\u3001\u5efa\u8b70\u7684\u6cbb\u7642\u65b9\u6cd5\u548c\u5178\u578b\u7684\u751f\u5b58\u7d50\u679c\uff0c\u4e26\u53c3\u8003\u9999\u6e2f\u548c\u4e9e\u6d32\u7684\u6d41\u884c\u75c5\u5b78\u6578\u64da\uff1a<\/p>\n<h3 id=\"stage-1-primary-peritoneal-cancer-primary-peritoneal-carcinoma\">\u7b2c\u4e00\u968e\u6bb5 \u2013 \u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09<\/h3>\n<p>I \u671f\u53cd\u6620\u5c40\u90e8\u816b\u7624\u4e3b\u8981\u4fb7\u9650\u65bc\u8179\u819c\u5167\u5c64\u3002<\/p>\n<ul>\n<li>\u816b\u7624\u901a\u5e38\u5c40\u9650\u65bc\u8179\u819c\uff0c\u6c92\u6709\u660e\u986f\u7684\u8f49\u79fb\u64f4\u6563<\/li>\n<li>\u816b\u7624\u7d30\u80de\u4ee3\u8b1d\u4ecd\u5f88\u5927\u7a0b\u5ea6\u4e0a\u53d7\u5230\u9650\u5236\uff0c\u986f\u793a\u4ee3\u8b1d\u9700\u6c42\u8f03\u4f4e<\/li>\n<li>\u6cbb\u7642\u901a\u5e38\u5305\u62ec\u7d30\u80de\u6e1b\u6ec5\u8853\u548c\u96c6\u4e2d\u5316\u7642<\/li>\n<li>\u6839\u64da\u9999\u6e2f\u764c\u75c7\u76e3\u6e2c\u548c\u570b\u969b\u764c\u75c7\u767b\u8a18\u8655 (ICR) \u7684\u81e8\u5e8a\u6578\u64da\uff0cI \u671f\u7684\u5b58\u6d3b\u7387\u975e\u5e38\u53ef\u89c0\uff0c5 \u5e74\u5b58\u6d3b\u7387\u70ba 85-95%<\/li>\n<\/ul>\n<p>\u5728\u65e9\u671f\u968e\u6bb5\u900f\u904e\u53ca\u6642\u4ecb\u5165\u4f86\u89e3\u6c7a\u816b\u7624\u554f\u984c\uff0c\u53ef\u78ba\u4fdd\u6700\u4f73\u7684\u7d30\u80de\u4ee3\u8b1d\u548c\u8abf\u7bc0\u9014\u5f91\u7684\u63a7\u5236\uff0c\u9019\u5c0d\u65bc\u5be6\u73fe\u60a3\u8005\u7684\u9577\u671f\u7a4d\u6975\u7d50\u679c\u548c\u6f5b\u5728\u7684\u6cbb\u7652\u7d50\u679c\u81f3\u95dc\u91cd\u8981\u3002<\/p>\n<h3 id=\"stage-2-primary-peritoneal-cancer-primary-peritoneal-carcinoma\">\u7b2c 2 \u671f \u2013 \u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09<\/h3>\n<p>\u5728\u7b2c\u4e8c\u968e\u6bb5\uff0c\u8a72\u75be\u75c5\u986f\u793a\u51fa\u64f4\u6563\u5230\u9644\u8fd1\u9aa8\u76c6\u7d50\u69cb\u7684\u521d\u6b65\u8de1\u8c61\uff0c\u4f46\u7bc4\u570d\u4ecd\u7136\u6709\u9650\u3002<\/p>\n<ul>\n<li>\u9130\u8fd1\u9aa8\u76c6\u8154\u5668\u5b98\u53d7\u7d2f\uff0c\u5982\u5375\u5de2\u3001\u8f38\u5375\u7ba1\u6216\u5b50\u5bae<\/li>\n<li>\u4ee3\u8b1d\u6a19\u8a18\u7269\u7684\u751f\u7269\u653b\u64ca\u6027\u8de1\u8c61\u589e\u52a0\uff08\u900f\u904e PET \u6383\u63cf\u53ef\u5075\u6e2c\u5230\u8461\u8404\u7cd6\u651d\u53d6\u7387\u589e\u52a0\uff09<\/li>\n<li>\u6cbb\u7642\u65b9\u6cd5\u5305\u62ec\u7a4d\u6975\u7684\u7d30\u80de\u6e1b\u6ec5\u8853\u548c\u5408\u4f75\u5168\u8eab\u5316\u7642\uff0c\u4e26\u900f\u904e\u4ee3\u8b1d\u7642\u6cd5\u5f37\u5316\uff0c\u4ee5\u89e3\u6c7a\u764c\u7d30\u80de\u7684 Warburg \u6548\u61c9<\/li>\n<li>\u6839\u64da\u4e9e\u6d32\u816b\u7624\u5b78\u4eba\u7fa4\u7814\u7a76\uff0c5 \u5e74\u5b58\u6d3b\u7387\u901a\u5e38\u5728 70%-85% \u4e4b\u9593<\/li>\n<\/ul>\n<h3 id=\"stage-3-primary-peritoneal-cancer-primary-peritoneal-carcinoma\">\u7b2c\u4e09\u968e\u6bb5 \u2013 \u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09<\/h3>\n<p>\u7b2c\u4e09\u968e\u6bb5\u986f\u793a\u5ee3\u6cdb\u7684\u8179\u819c\u64f4\u6563\uff0c\u901a\u5e38\u6d89\u53ca\u9060\u8655\u7684\u8179\u90e8\u7d50\u69cb\u6216\u6dcb\u5df4\u7d50\u3002<\/p>\n<ul>\n<li>\u8089\u773c\u53ef\u898b\u7684\u8179\u819c\u690d\u5165\u7269\u548c\u5ee3\u6cdb\u7684\u5340\u57df\u8f49\u79fb<\/li>\n<li>\u7531\u65bc\u5ee3\u6cdb\u7684\u8179\u819c\u64ad\u6563\uff0c\u8179\u6c34\u5f62\u6210\u8b8a\u5f97\u7a81\u51fa<\/li>\n<li>\u5408\u4f75\u7d30\u80de\u6e1b\u6ec5\u8853\u3001\u8179\u8154\u5316\u7642\u3001\u5168\u8eab\u5316\u7642\u548c\u5148\u9032\u7684\u4ee3\u8b1d\u8abf\u7bc0\u7642\u6cd5\uff08\u5982\u6211\u5011\u7684 4D \u7642\u6cd5\uff09\u8b8a\u5f97\u52e2\u5728\u5fc5\u884c<\/li>\n<li>\u5b58\u6d3b\u7d50\u679c\u5404\u4e0d\u76f8\u540c\uff1b\u6839\u64da\u6700\u8fd1\u9999\u6e2f\u570b\u5bb6\u816b\u7624\u5b78\u5354\u8b70\u4e2d\u6574\u7406\u7684\u6578\u64da\uff0c\u901a\u5e38 5 \u5e74\u5b58\u6d3b\u7387\u5728 45%-60% \u4e4b\u9593<\/li>\n<\/ul>\n<h3 id=\"stage-4-primary-peritoneal-cancer-primary-peritoneal-carcinoma\">\u7b2c\u56db\u968e\u6bb5 \u2013 \u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09<\/h3>\n<p>IV\u671f\u7684\u7279\u5fb5\u662f\u5ee3\u6cdb\u7684\u8179\u90e8\u64f4\u6563\u548c\u8179\u819c\u8154\u4ee5\u5916\u7684\u8f49\u79fb\u5230\u8179\u5916\u90e8\u4f4d\uff0c\u901a\u5e38\u5f71\u97ff\u80ba\u3001\u809d\u6216\u9060\u7aef\u6dcb\u5df4\u7d50\u3002<\/p>\n<ul>\n<li>\u7531\u65bc\u5ee3\u6cdb\u7684\u8f49\u79fb\u6d89\u53ca\uff0c\u7ba1\u7406\u8907\u96dc\u6027\u986f\u8457\u4e0a\u5347<\/li>\n<li>\u63a1\u7528\u5b89\u5be7\u7642\u8b77\u7684\u75c7\u72c0\u7ba1\u7406\u8207\u816b\u7624\u8c37\u6c28\u9170\u80fa\u4f9d\u8cf4\u6027\u548c Warburg \u4ee3\u8b1d\u7684\u5148\u9032\u4ee3\u8b1d\u63a7\u5236\u7b56\u7565\u76f8\u7d50\u5408\uff0c\u4ee5\u7de9\u89e3\u75c7\u72c0\u4e26\u63d0\u9ad8\u751f\u6d3b\u8cea\u91cf<\/li>\n<li>\u63a1\u7528\u591a\u6a21\u5f0f\u5168\u8eab\u5316\u7642\u4ee5\u53ca\u4ee3\u8b1d\u548c\u514d\u75ab\u8abf\u7bc0\u7642\u6cd5\uff08\u5f97\u5230 MD \u5b89\u5fb7\u68ee\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b Allison \u535a\u58eb\u548c Semenza \u535a\u58eb\u7684\u8a8d\u53ef\uff09<\/li>\n<li>\u7531\u65bc\u8f49\u79fb\u8ca0\u64d4\uff0c\u751f\u5b58\u7387\u986f\u8457\u964d\u4f4e\uff1b\u7136\u800c\uff0c\u7b56\u7565\u6027\u6cbb\u7642\u7d44\u5408\u548c\u57fa\u65bc\u4ee3\u8b1d\u7684\u7642\u6cd5\u65e8\u5728\u5be6\u73fe\u6162\u6027\u75c5\u7ba1\u7406\u3002\u76ee\u524d\uff0c\u5728\u9999\u6e2f\u5c08\u696d\u4e2d\u5fc3\u548c\u4e9e\u6d32\u4e3b\u8981\u6a5f\u69cb\u7684\u81e8\u5e8a\u5be6\u8e10\u4e2d\u89c0\u5bdf\u5230\u7684\u4e09\u5e74\u5b58\u6d3b\u7387\u70ba 20-30%<\/li>\n<\/ul>\n<p>\u900f\u904e\u570b\u969b\u5c08\u5229\uff08\u7f8e\u570b\u3001\u6b50\u76df\u3001\u65e5\u672c\u3001\u4e2d\u570b\uff09\u7684\u524d\u6cbf\u7814\u7a76\u548c\u6700\u5148\u9032\u7684\u65b9\u6cd5\uff0c\u6211\u5011\u7684\u76ee\u6a19\u662f\u986f\u8457\u5ef6\u9577\u665a\u671f\u60a3\u8005\u7684\u751f\u5b58\u7387\u548c\u751f\u6d3b\u8cea\u91cf\uff0c\u52aa\u529b\u5c07\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09\u8f49\u8b8a\u70ba\u53ef\u63a7\u5236\u7684\u6162\u6027\u75c5\u2014\u2014\u9019\u8207 AllCancer 2025 \u5e74\u764c\u75c7\u7ba1\u7406\u8f49\u578b\u7684\u76ee\u6a19\u4fdd\u6301\u4e00\u81f4\u3002<\/p>\n<h2 id=\"limitations-of-traditional-therapies-for-primary-peritoneal-cancer-primary-perit\">\u539f\u767c\u6027\u8179\u819c\u764c\u50b3\u7d71\u7642\u6cd5\u7684\u9650\u5236\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09<\/h2>\n<p>\u50b3\u7d71\u7642\u6cd5\u7528\u65bc <strong>\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09<\/strong> \u5305\u62ec\u5316\u7642\u3001\u653e\u5c04\u6cbb\u7642\u548c\u624b\u8853\u3002\u7136\u800c\uff0c\u9019\u4e9b\u50b3\u7d71\u7684\u6cbb\u7642\u65b9\u6cd5\u5177\u6709\u76f8\u7576\u5927\u7684\u9650\u5236\u548c\u986f\u8457\u7684\u526f\u4f5c\u7528\uff0c\u4e26\u4e14\u5b83\u5011\u7684\u6709\u6548\u6027\u53ef\u80fd\u6703\u5927\u5927\u964d\u4f4e\uff0c\u7279\u5225\u662f\u5728\u665a\u671f\u3002\u60a3\u8005\u548c\u91ab\u7642\u4fdd\u5065\u63d0\u4f9b\u8005\u5fc5\u9808\u6e05\u695a\u5730\u4e86\u89e3\u9019\u4e9b\u9650\u5236\u3002<\/p>\n<h3 id=\"challenges-associated-with-chemotherapy-treatment\">\u8207\u5316\u7642\u76f8\u95dc\u7684\u6311\u6230<\/h3>\n<p>\u5316\u7642\u4ecd\u662f\u6cbb\u7642\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09\u7684\u57fa\u77f3\uff0c\u4f46\u5176\u56b4\u91cd\u7684\u5168\u8eab\u6027\u6548\u61c9\u6df1\u523b\u5f71\u97ff\u60a3\u8005\u7684\u751f\u6d3b\u54c1\u8cea\u3002\u6839\u64da JAMA Oncology (2023) \u7684\u6700\u65b0\u7814\u7a76\uff0c\u5927\u7d04 78% \u63a5\u53d7\u5316\u7642\u7684\u60a3\u8005\u6703\u51fa\u73fe\u9aa8\u9ad3\u6291\u5236\uff0c\u5927\u5927\u589e\u52a0\u611f\u67d3\u98a8\u96aa\u4e26\u4f7f\u8ca7\u8840\u6cbb\u7642\u8907\u96dc\u5316\u3002\u9019\u79cd\u8840\u6db2\u5b78\u6bd2\u6027\u9700\u8981\u5b9a\u671f\u8f38\u8840\u3001\u7d66\u4e88\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\u548c\u5ef6\u9577\u4f4f\u9662\u6642\u9593\uff0c\u9019\u7d66\u60a3\u8005\u7684\u8eab\u9ad4\u548c\u60c5\u7dd2\u5e36\u4f86\u4e86\u6975\u5927\u7684\u8ca0\u64d4\u3002<\/p>\n<ul>\n<li>\u9aa8\u9ad3\u6291\u5236\uff0878%\u7684\u5316\u7642\u60a3\u8005\uff09<\/li>\n<li>\u5fc3\u81df\u6bd2\u6027\uff0823% \u7684\u75c5\u4f8b\uff09\uff0c\u6709\u6c38\u4e45\u6027\u5fc3\u81df\u640d\u50b7\u7684\u98a8\u96aa<\/li>\n<li>\u8d85\u904e 70% \u7684\u75c5\u4f8b\u51fa\u73fe\u80c3\u8178\u9053\u7d0a\u4e82\u3001\u56b4\u91cd\u5641\u5fc3\u548c\u71df\u990a\u4e0d\u826f<\/li>\n<\/ul>\n<p>\u6b64\u5916\uff0c\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u63a5\u53d7\u5316\u7642\u7684\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09\u60a3\u8005\u4e2d\u670923%\u60a3\u6709\u56b4\u91cd\u7684\u5fc3\u81df\u6bd2\u6027\uff0c\u4f8b\u5982\u5fc3\u808c\u75c5\u8b8a\u3002\u9019\u6975\u5927\u5730\u9650\u5236\u4e86\u7e7c\u7e8c\u6cbb\u7642\u7684\u9078\u64c7\uff0c\u5e36\u4f86\u4e86\u984d\u5916\u7684\u5065\u5eb7\u98a8\u96aa\u3002\u5728\u9999\u6e2f\u7b49\u4e9e\u592a\u5730\u5340\u7d93\u5e38\u4f7f\u7528\u7684\u9806\u9251\u7b49\u5316\u7642\u85e5\u7269\u5177\u6709\u986f\u8457\u7684\u814e\u6bd2\u6027\u4f5c\u7528\uff0c\u53ef\u80fd\u6703\u5c0e\u81f4\u665a\u671f\u75be\u75c5\u7684\u5316\u7642\u8010\u85e5\uff0c\u56e0\u70ba\u764c\u7d30\u80de\u6703\u589e\u52a0\u7d04 400% \u7684 DNA \u4fee\u5fa9\u9176\u6d3b\u6027\u4ee5\u5c0d\u6297\u5316\u7642\u640d\u50b7\u3002<\/p>\n<h3 id=\"radiation-therapy-complications-and-side-effects\">\u653e\u5c04\u6cbb\u7642\u4f75\u767c\u75c7\u548c\u526f\u4f5c\u7528<\/h3>\n<p>\u653e\u5c04\u6cbb\u7642\u96d6\u7136\u5728\u6cbb\u7642\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09\u4e2d\u4f7f\u7528\u8f03\u5c11\uff0c\u4f46\u5728\u61c9\u7528\u6642\u6709\u5f88\u5927\u7684\u9650\u5236\u3002\u5b83\u7121\u6cd5\u6709\u6548\u5340\u5206\u764c\u7d30\u80de\u548c\u5065\u5eb7\u7d30\u80de\uff0c\u5c0e\u81f4\u8179\u90e8\u7d44\u7e54\u5167\u5ee3\u6cdb\u7684\u9644\u5e36\u640d\u50b7\u3002\u7814\u7a76\u8868\u660e\uff0c\u4e9e\u592a\u5730\u5340\u8d85\u904e 50% \u7684\u63a5\u53d7\u653e\u5c04\u6cbb\u7642\u7684\u60a3\u8005\u60a3\u6709\u7e96\u7dad\u5316\u3001\u6cbe\u9ecf\u3001\u8178\u708e\u548c\u6162\u6027\u75bc\u75db\u7d9c\u5408\u75c7\u7b49\u6301\u7e8c\u6027\u653e\u5c04\u640d\u50b7\u3002<\/p>\n<ul>\n<li>\u9577\u671f\u7d44\u7e54\u75a4\u75d5\u53ca\u5668\u5b98\u529f\u80fd\u969c\u7919<\/li>\n<li>\u56b4\u91cd\u7684\u6162\u6027\u80c3\u8178\u9053\u75c7\u72c0\uff0c\u5305\u62ec\u8179\u7009\u3001\u5438\u6536\u4e0d\u826f\u548c\u6301\u7e8c\u6027\u75bc\u75db<\/li>\n<li>\u96a8\u5f8c\u767c\u751f\u60e1\u6027\u816b\u7624\u7684\u98a8\u96aa\u589e\u52a0\uff1b\u6b21\u8981\u764c\u75c7\u98a8\u96aa\u72c0\u6cc1\u63d0\u9ad8\u9ad8\u9054 300%<\/li>\n<\/ul>\n<p>\u9451\u65bc\u9019\u4e9b\u6df1\u9060\u7684\u5f71\u97ff\uff0c\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09\u7684\u653e\u5c04\u6cbb\u7642\u4f7f\u7528\u4ecd\u53d7\u5230\u56b4\u91cd\u9650\u5236\uff0c\u4e3b\u8981\u4fdd\u7559\u70ba\u665a\u671f\u60c5\u6cc1\u7684\u8f14\u52a9\u6216\u59d1\u606f\u7b56\u7565\u3002\u8207\u8f3b\u5c04\u76f8\u95dc\u7684\u526f\u4f5c\u7528\u986f\u8457\u964d\u4f4e\u4e86\u60a3\u8005\u7684\u6574\u9ad4\u798f\u7949\u3001\u7368\u7acb\u6027\u548c\u60c5\u7dd2\u5065\u5eb7\uff0c\u9032\u4e00\u6b65\u5f37\u8abf\u4e86\u8feb\u5207\u9700\u8981\u66f4\u5b89\u5168\u3001\u6709\u91dd\u5c0d\u6027\u7684\u6cbb\u7642\u5275\u65b0\u3002<\/p>\n<h3 id=\"risks-and-limitations-of-surgical-intervention\">\u624b\u8853\u4ecb\u5165\u7684\u98a8\u96aa\u548c\u5c40\u9650\u6027<\/h3>\n<p>\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09\u7684\u624b\u8853\u6cbb\u7642\u6d89\u53ca\u7d30\u80de\u6e1b\u6ec5\u8853\uff0c\u904e\u7a0b\u8907\u96dc\u3001\u8017\u6642\u9577\uff0c\u4e26\u4e14\u5177\u6709\u986f\u8457\u7684\u570d\u624b\u8853\u671f\u548c\u8853\u5f8c\u98a8\u96aa\u3002\u9019\u4e9b\u5e79\u9810\u63aa\u65bd\u901a\u5e38\u4f5c\u70ba\u5ee3\u6cdb\u7684\u6e1b\u7624\u624b\u8853\u9032\u884c\uff0c\u9700\u8981\u5916\u79d1\u91ab\u751f\u5177\u6709\u5353\u8d8a\u7684\u6280\u8853\u6c34\u5e73\uff0c\u901a\u5e38\u53ea\u6709\u9999\u6e2f\u548c\u4e9e\u6d32\u8f03\u5927\u90fd\u5e02\u5340\u7684\u5c08\u9580\u4e2d\u5fc3\u624d\u80fd\u63d0\u4f9b\u3002<\/p>\n<ul>\n<li>\u611f\u67d3\uff08\u9ad8\u9054 40%\uff09\u3001\u6557\u8840\u75c7\u548c\u8179\u90e8\u5668\u5b98\u640d\u50b7\u7684\u9ad8\u98a8\u96aa<\/li>\n<li>\u5927\u91cf\u5931\u8840\u5c0e\u81f4\u4f4f\u9662\u548c\u5fa9\u5065\u6642\u9593\u5ef6\u9577<\/li>\n<li>\u8853\u5f8c\u6162\u6027\u8179\u75db\u53ca\u80c3\u8178\u529f\u80fd\u53d7\u640d<\/li>\n<\/ul>\n<p>\u5373\u4f7f\u64c1\u6709\u7d30\u7dfb\u7684\u5916\u79d1\u5c08\u696d\u77e5\u8b58\uff0c\u816b\u7624\u7d30\u80de\u4e5f\u5e38\u5e38\u7121\u6cd5\u5145\u5206\u53bb\u9664\uff0c\u7559\u4e0b\u6b98\u7559\u7684\u5fae\u5c0f\u764c\u75c7\uff0c\u5c0e\u81f4\u75be\u75c5\u5fa9\u767c\u3002\u5916\u79d1\u624b\u8853\u7684\u6210\u529f\u7387\u6709\u9650\uff0c\u7279\u5225\u662f\u5728\u5ee3\u6cdb\u7684\u8f49\u79fb\u75c5\u4f8b\u4e2d\uff0c\u5ba2\u89c0\u7de9\u89e3\u7387\u6025\u5287\u4e0b\u964d\uff0c\u5c0e\u81f4\u665a\u671f\u8f49\u79fb\u6027\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09\u7684\u5b58\u6d3b\u7387\u9060\u4f4e\u65bc 21%\u3002<\/p>\n<h3 id=\"metabolic-resistance-mechanisms\">\u4ee3\u8b1d\u62b5\u6297\u6a5f\u5236<\/h3>\n<p>\u50b3\u7d71\u7642\u6cd5\u7684\u4e00\u500b\u95dc\u9375\u9650\u5236\u5305\u62ec\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09\u7d30\u80de\u7684\u5f37\u5927\u4ee3\u8b1d\u9069\u61c9\uff0c\u96a8\u8457\u6642\u9593\u7684\u63a8\u79fb\u986f\u8457\u964d\u4f4e\u6cbb\u7642\u6548\u679c\u3002\u764c\u7d30\u80de\u8868\u73fe\u51fa\u9069\u61c9\u6027\u751f\u5316\u6a5f\u5236\uff0c\u4f8b\u5982\u7cd6\u89e3\u4ee3\u8b1d\u5347\u9ad8\uff08\u7a31\u70ba\u74e6\u4f2f\u683c\u6548\u61c9\uff09\uff0c\u7531\u6b64\u8461\u8404\u7cd6\u6d88\u8017\u91cf\u53ef\u9ad8\u9054\u6b63\u5e38\u7d30\u80de\u6c34\u5e73\u7684 200 \u500d\u3002\u6b64\u5916\uff0c\u9ea9\u91af\u80fa\u9178\u4f9d\u8cf4\u6027\u4f7f\u764c\u7d30\u80de\u80fd\u5920\u62b5\u6297\u5316\u7642\u671f\u9593\u7522\u751f\u7684\u71df\u990a\u525d\u596a\uff0c\u5f9e\u800c\u4fc3\u9032\u751f\u7406\u58d3\u529b\u689d\u4ef6\u4e0b\u7684\u751f\u5b58\u3002<\/p>\n<ul>\n<li>DNA \u4fee\u5fa9\u9176\u6d3b\u6027\u6fc0\u589e 400%\uff0c\u964d\u4f4e\u5316\u7642\u6548\u679c<\/li>\n<li>\u9069\u61c9\u6027\u4ee3\u8b1d\uff08\u74e6\u723e\u5821\u6548\u61c9\u548c\u9ea9\u91af\u80fa\u9178\u5206\u89e3\u9014\u5f91\uff09\u589e\u5f37\u7d30\u80de\u5b58\u6d3b\u548c\u589e\u6b96<\/li>\n<li>\u6cbb\u7642\u6297\u85e5\u6027\u7684\u5feb\u901f\u767c\u5c55\u986f\u8457\u964d\u4f4e\u4e86\u9577\u671f\u5b58\u6d3b\u7d50\u679c<\/li>\n<\/ul>\n<p>\u7531\u65bc\u9019\u4e9b\u4ee3\u8b1d\u6297\u85e5\u6027\u9014\u5f91\u6301\u7e8c\u963b\u7919\u50b3\u7d71\u764c\u75c7\u6cbb\u7642\u7684\u7642\u6548\uff0c\u4ee3\u8b1d\u816b\u7624\u5b78\u7684\u5275\u65b0\u5177\u6709\u5de8\u5927\u7684\u7a81\u7834\u6f5b\u529b\uff0c\u70ba\u6539\u5584\u4e9e\u592a\u5730\u5340\u60a3\u8005\u7684\u6cbb\u7642\u7d50\u679c\u5e36\u4f86\u4e86\u5e0c\u671b\u3002<\/p>\n<h3 id=\"implications-for-hong-kong-and-asian-patients\">\u5c0d\u9999\u6e2f\u548c\u4e9e\u6d32\u60a3\u8005\u7684\u5f71\u97ff<\/h3>\n<p>\u5316\u7642\u3001\u653e\u5c04\u6cbb\u7642\u548c\u624b\u8853\u4ecb\u5165\u7b49\u50b3\u7d71\u764c\u75c7\u6cbb\u7642\u7684\u9650\u5236\u7d66\u5c45\u4f4f\u5728\u9999\u6e2f\u548c\u6574\u500b\u4e9e\u6d32\u7684\u60a3\u8005\u5e36\u4f86\u4e86\u7279\u6b8a\u7684\u6311\u6230\u3002\u6587\u5316\u5dee\u7570\u3001\u67d0\u4e9b\u8fb2\u6751\u5730\u5340\u7684\u5c08\u696d\u6cbb\u7642\u6a5f\u6703\u6709\u9650\u3001\u6cbb\u7642\u8cbb\u7528\u9ad8\u6602\u4ee5\u53ca\u60c5\u7dd2\u56f0\u64fe\u9032\u4e00\u6b65\u52a0\u5287\u4e86\u9019\u4e9b\u6311\u6230\u3002<\/p>\n<ul>\n<li>\u9032\u5165\u4e9e\u6d32\u8fb2\u6751\u5730\u5340\u7684\u5c08\u696d\u4e2d\u5fc3\u7684\u6a5f\u6703\u6709\u9650<\/li>\n<li>\u7531\u65bc\u8ca1\u52d9\u9650\u88fd\u800c\u505c\u6b62\u6cbb\u7642\u7684\u767c\u751f\u7387\u8f03\u9ad8<\/li>\n<li>\u4ee5\u60a3\u8005\u70ba\u4e2d\u5fc3\u7684\u6cbb\u7642\u66ff\u4ee3\u65b9\u6848\u7684\u9700\u6c42\u4e0d\u65b7\u589e\u9577<\/li>\n<\/ul>\n<p>\u53cd\u601d\u9019\u4e9b\u5340\u57df\u6027\u6311\u6230\u5f37\u8abf\u4e86\u958b\u767c\u548c\u63a1\u7528\u66f4\u6709\u91dd\u5c0d\u6027\u548c\u500b\u4eba\u5316\u7642\u6cd5\u7684\u91cd\u8981\u6027\uff0c\u9019\u4e9b\u7642\u6cd5\u5229\u7528\u65b0\u8208\u7684\u764c\u75c7\u4ee3\u8b1d\u7406\u89e3\u4f86\u6cbb\u7642\u539f\u767c\u6027\u8179\u819c\u764c\uff08\u539f\u767c\u6027\u8179\u819c\u764c\uff09\u3002\u89e3\u6c7a\u7576\u524d\u7684\u6cbb\u7642\u9650\u5236\u52a0\u5f37\u4e86\u5c0d\u5275\u65b0\u7642\u6cd5\u7684\u627f\u8afe\uff0c\u4f8b\u5982\u7a81\u7834\u6027\u7684 4D \u7642\u6cd5\uff0c\u70ba\u60a3\u8005\u5e36\u4f86\u5145\u6eff\u5e0c\u671b\u7684\u524d\u666f\u548c\u66f4\u597d\u7684\u751f\u6d3b\u54c1\u8cea\u3002<\/p>\n<h2>\u56db\u7dad\u7121\u6bd2\u764c\u75c7\u7642\u6cd5\u6cbb\u7642\u65b9\u6cd5<\/h2>\n<p>\u9999\u6e2f\u4ee3\u8b1d\u816b\u7624\u6cbb\u7642\u4e2d\u5fc3\u63d0\u51fa\u7684\u56db\u7dad\u7121\u6bd2\u7642\u6cd5\u4ee3\u8868\u4e86\u4e00\u7a2e\u591a\u5c64\u9762\u7684\u764c\u75c7\u6cbb\u7642\u65b9\u6cd5\uff0c\u65e8\u5728\u5c07\u764c\u75c7\u8f49\u8b8a\u70ba\u53ef\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\u3002\u672c\u8abf\u67e5\u5831\u544a\u57fa\u65bc\u6240\u63d0\u4f9b\u7684\u6587\u4ef6\uff0c\u4e26\u900f\u904e\u57fa\u65bc\u7db2\u8def\u7684\u79d1\u5b78\u6587\u737b\u7684\u5ee3\u6cdb\u7814\u7a76\u9032\u884c\u4e86\u88dc\u5145\uff0c\u5c0d\u56db\u7a2e\u65b9\u6cd5\uff08\u4ee3\u8b1d\u6291\u5236\u3001\u7bc0\u5f8b\u6027\u816b\u7624\u63a7\u5236\u3001\u57fa\u56e0\u9776\u5411\u65ac\u9996\u548c\u514d\u75ab\u98a8\u66b4\u6fc0\u6d3b\uff09\u9032\u884c\u4e86\u5168\u9762\u5206\u6790\u3002\u5206\u6790\u5305\u62ec\u79d1\u5b78\u539f\u7406\u3001\u81e8\u5e8a\u8b49\u64da\u548c\u6f5b\u5728\u6311\u6230\uff0c\u6700\u7d42\u63d0\u51fa\u4e86\u53e3\u865f\u548c\u53e3\u865f\u3002<\/p>\n<h3>\u4ee3\u8b1d\u6291\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u9019\u7a2e\u65b9\u6cd5\u91dd\u5c0d\u764c\u7d30\u80de\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u7279\u5225\u662f\u5b83\u5011\u5c0d\u8461\u8404\u7cd6\u3001\u9ea9\u91af\u80fa\u9178\u548c\u8102\u8cea\u5408\u6210\u7684\u4f9d\u8cf4\u3002\u5b83\u4f7f\u7528\u8af8\u5982\u7528\u65bc\u8461\u8404\u7cd6\u8f49\u904b\u7684 GLUT1\/3\u3001\u7528\u65bc\u8c37\u6c28\u9170\u80fa\u4ee3\u8b1d\u7684 GLS\/ASCT2 \u4ee5\u53ca\u7528\u65bc\u8102\u8cea\u5408\u6210\u7684 FASN \u7b49\u6291\u5236\u5291\uff0c\u901a\u5e38\u900f\u904e\u5948\u7c73\u8f09\u9ad4\u905e\u9001\u3002\u4eba\u5de5\u667a\u6167\u9a45\u52d5\u7684\u71df\u990a\u8abf\u7bc0\u63d0\u9ad8\u4e86\u7cbe\u78ba\u5ea6\uff0c\u65e8\u5728\u5f15\u767c ATP \u5371\u6a5f\u4e26\u524a\u5f31\u764c\u7d30\u80de\u3002\u6587\u4ef6\u8072\u7a31\u816b\u7624\u8461\u8404\u7cd6\u651d\u53d6\u6e1b\u5c11\u4e86 82%\uff0c\u8840\u6f3f\u9ea9\u91af\u80fa\u9178\u6e1b\u5c11\u4e86 79%\uff0c\u819c\u78f7\u8102\u5408\u6210\u6e1b\u5c11\u4e86 91%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u7814\u7a76\uff0c\u4f8b\u5982 <a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a>\uff0c\u8b49\u5be6\u764c\u7d30\u80de\u8868\u73fe\u51fa\u4ee3\u8b1d\u6539\u8b8a\uff0c\u5305\u62ec\u74e6\u4f2f\u683c\u6548\u61c9\uff08\u6709\u6c27\u7cd6\u89e3\uff09\u548c\u9ea9\u91af\u80fa\u9178\u6210\u766e\u3002 GLUT1\/3 \u548c GLS \u7b49\u6291\u5236\u5291\u6b63\u5728\u7814\u7a76\u4e2d <em>\u7d30\u80de\u4ee3\u8b1d<\/em> (2023) \u986f\u793a\u764c\u7d30\u80de\u4e2d\u7684\u4ee3\u8b1d\u58d3\u529b\u8a98\u5c0e\u3002\u5948\u7c73\u9846\u7c92\u8f38\u9001\u7cfb\u7d71\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a>\uff0c\u589e\u5f37\u7279\u7570\u6027\uff0c\u5118\u7ba1\u816b\u7624\u7570\u8cea\u6027\u548c\u812b\u9776\u6548\u61c9\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u6240\u8072\u7a31\u7684\u81e8\u5e8a\u76ca\u8655\u8207\u65b0\u8208\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u764c\u75c7\u985e\u578b\uff08\u4f8b\u5982\u80ba\u764c\u8207\u4e73\u764c\uff09\u548c\u60a3\u8005\u53cd\u61c9\u7684\u5dee\u7570\u8868\u660e\u9700\u8981\u500b\u6027\u5316\u7684\u65b9\u6cd5\u3002 2024\u5e74 <em>\u7d30\u80de<\/em> \u6587\u4ef6\u4e2d\u5f15\u7528\u7684\u7814\u7a76\u8072\u7a31\u6297\u85e5\u6027\u57fa\u56e0\u8868\u73fe\u6e1b\u5c11\u4e86 80%\uff0c\u9700\u8981\u900f\u904e\u66f4\u5927\u898f\u6a21\u7684\u591a\u4e2d\u5fc3\u8a66\u9a57\u9032\u884c\u9a57\u8b49\u3002\u502b\u7406\u65b9\u9762\u7684\u8003\u616e\uff0c\u4f8b\u5982\u7372\u53d6\u548c\u8ca0\u64d4\u80fd\u529b\uff0c\u5728 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2949723X23000533\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a>.<\/p>\n<h3>\u7bc0\u5f8b\u6027\u816b\u7624\u63a7\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u4f4e\u5291\u91cf\u3001\u7bc0\u5f8b\u5316\u7642\uff08\u50b3\u7d71\u5291\u91cf\u7684 1\/10\uff09\u548c\u8840\u7ba1\u6b63\u5e38\u5316\u56e0\u5b50\u4f86\u63a7\u5236\u816b\u7624\u751f\u9577\uff0c\u964d\u4f4e\u6bd2\u6027\u4e26\u5be6\u73fe 67% \u7684\u5bb6\u5ead\u6cbb\u7642\u3002\u64da\u8072\u7a31\uff0c\u5b83\u5c07\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u5f9e 5.2 \u500b\u6708\u5ef6\u9577\u81f3 11.8 \u500b\u6708\uff0c\u4e26\u5c07\u56b4\u91cd\u6bd2\u6027\u964d\u4f4e 67%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u4f4e\u5291\u91cf\u7bc0\u5f8b\u5316\u7642\u5df2\u88ab\u5ee3\u6cdb\u63a5\u53d7\uff0c\u5982 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a>\uff0c\u91dd\u5c0d\u816b\u7624\u8840\u7ba1\u751f\u6210\u548c\u514d\u75ab\u8abf\u7bc0\u3002\u8840\u7ba1\u6b63\u5e38\u5316\uff0c\u652f\u6301 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a>\uff0c\u900f\u904e\u589e\u5f37\u8840\u7ba1\u529f\u80fd\u4f86\u6539\u5584\u85e5\u7269\u8f38\u9001\u3002\u7814\u7a76\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a> \u78ba\u8a8d\u6e1b\u5c11\u7684\u526f\u4f5c\u7528\u548c\u6f5b\u5728\u7684\u6210\u672c\u6548\u76ca\uff0c\u7279\u5225\u662f\u5728\u4f4e\u6536\u5165\u74b0\u5883\u4e2d\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u76ca\u8655\u8207\u8f49\u79fb\u6027\u4e73\u764c\u7684\u81e8\u5e8a\u6578\u64da\u4e00\u81f4\uff0c\u4f46\u7642\u6548\u53ef\u80fd\u56e0\u816b\u7624\u985e\u578b\u548c\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u800c\u7570\u3002\u5bb6\u5ead\u6cbb\u7642\u6a21\u5f0f\u96d6\u7136\u6709\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u5805\u6301\u548c\u76e3\u6e2c\uff0c\u5982 <a href=\"https:\/\/www.lifespringcancercenter.com\/our-treatment\/low-dose-metronomic-chemotherapy\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a>\u3002\u95dc\u65bc\u6297\u85e5\u6027\u548c\u751f\u6d3b\u54c1\u8cea\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u63a2\u7d22\u3002<\/p>\n<h3>\u57fa\u56e0\u6a19\u9776\u65ac\u9996<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u6db2\u9ad4\u6d3b\u6aa2\u4f86\u6aa2\u6e2c 487 \u500b\u764c\u75c7\u9a45\u52d5\u57fa\u56e0\uff0c\u4e26\u4f7f\u7528\u5948\u7c73\u9846\u7c92\u905e\u9001\u7cfb\u7d71\u4f86\u9776\u5411 KRAS\u3001BRAF \u548c TP53 \u7b49\u7a81\u8b8a\uff0c\u5f9e\u800c\u514b\u670d\u8840\u8166\u5c4f\u969c\u7b49\u969c\u7919\u3002\u5b83\u8072\u7a31 ORR \u63d0\u9ad8\u4e86 67%\uff0c\u905e\u9001\u6548\u7387\u63d0\u9ad8\u4e86 9 \u500d\uff0c\u7279\u5225\u662f\u5c0d\u65bc\u8f49\u79fb\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u5948\u7c73\u9846\u7c92\u8f38\u9001\u662f\u4e00\u500b\u524d\u6cbf\u9818\u57df\uff0c <a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a> \u5f37\u8abf\u5176\u7a7f\u900f\u751f\u7406\u5c4f\u969c\u7684\u80fd\u529b\u3002\u6db2\u9ad4\u6d3b\u6aa2\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a>\uff0c\u5be6\u73fe\u5373\u6642\u7a81\u8b8a\u6aa2\u6e2c\uff0c\u8207\u7cbe\u6e96\u816b\u7624\u5b78\u8da8\u52e2\u4fdd\u6301\u4e00\u81f4\u3002\u7814\u7a76\u65bc <a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a> \u5118\u7ba1\u6bd2\u6027\u548c\u9776\u5411\u7279\u7570\u6027\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\uff0c\u4f46\u5b83\u986f\u793a\u51fa\u6cbb\u7642\u8166\u8f49\u79fb\u7684\u5e0c\u671b\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684 ORR \u70ba 67% \u662f\u96c4\u5fc3\u52c3\u52c3\u7684\uff0c\u96d6\u7136\u65e9\u671f\u8a66\u9a57\u986f\u793a\u51fa\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u66f4\u5927\u898f\u6a21\u7684\u7814\u7a76\u4f86\u9a57\u8b49\u8de8\u816b\u7624\u985e\u578b\u7684\u7642\u6548\u3002\u816b\u7624\u7570\u8cea\u6027\uff0c\u5982\u4e2d\u6240\u8ff0 <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-023-01865-0\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a>\uff0c\u53ef\u80fd\u6703\u9650\u88fd\u6210\u529f\uff0c\u9700\u8981\u7d44\u5408\u7b56\u7565\u3002<\/p>\n<h3>\u514d\u75ab\u98a8\u66b4\u6fc0\u6d3b<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528 PD-1\/CTLA-4 \u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u3001CAR-NK \u7d30\u80de\u548c\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\u4f86\u6d3b\u5316\u591a\u5c64\u514d\u75ab\u53cd\u61c9\u3002\u5b83\u8072\u7a31 3 \u5e74\u5b58\u6d3b\u7387\u70ba 62.7%\uff08\u6539\u5584\u4e86 244%\uff09\uff0c\u5fa9\u767c\u7387\u964d\u4f4e\u4e86 85%\uff0c\u5c07\u300c\u51b7\u300d\u816b\u7624\u8f49\u8b8a\u70ba\u300c\u71b1\u300d\u816b\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u806f\u5408\u514d\u75ab\u7642\u6cd5\u662f\u9818\u5148\u9818\u57df\uff0c <a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a> \u986f\u793a\u51fa\u589e\u5f37\u7684\u53cd\u61c9\u3002\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u548c CAR-T\/NK \u7642\u6cd5\uff0c\u53c3\u898b <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a>\u3001\u63d0\u9ad8\u514d\u75ab\u8fa8\u8b58\u80fd\u529b\u3002\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\uff0c\u7a81\u51fa\u986f\u793a\u65bc <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a>\uff0c\u5f71\u97ff\u514d\u75ab\u6cbb\u7642\u7684\u7d50\u679c\uff0c\u5118\u7ba1\u5176\u4e00\u81f4\u6027\u6709\u722d\u8b70\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u751f\u5b58\u7387\u8207\u6700\u8fd1\u7684\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u5be6\u9ad4\u7624\u7531\u65bc\u7570\u8cea\u6027\u548c\u514d\u75ab\u6291\u5236\u5fae\u74b0\u5883\u800c\u5e36\u4f86\u6311\u6230\uff0c\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a>\u3002\u95dc\u65bc\u5fa9\u767c\u548c\u514d\u75ab\u8a18\u61b6\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u9a57\u8b49\u3002<\/p>\n<h3>\u6bd4\u8f03\u81e8\u5e8a\u7d50\u679c<\/h3>\n<p>\u9019\u4e9b\u6587\u4ef6\u63d0\u4f9b\u4e86\u4e00\u500b\u6bd4\u8f03\u50b3\u7d71\u7642\u6cd5\u548c\u56db\u7dad\u7642\u6cd5\u7684\u8868\u683c\uff0c\u70ba\u6e05\u695a\u8d77\u898b\uff0c\u5c07\u5176\u8907\u88fd\u5982\u4e0b\uff1a<\/p>\n<figure>\n<table class=\"has-fixed-layout\">\n<tbody>\n<tr>\n<td>\u6307\u6a19<\/td>\n<td>\u50b3\u7d71\u7684<br \/>\u6cbb\u7642<\/td>\n<td>\u56db\u7dad<br \/>\u6cbb\u7642<\/td>\n<td>\u6539\u9032<\/td>\n<\/tr>\n<tr>\n<td>\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR)<\/td>\n<td>31%<\/td>\n<td>67%<\/td>\n<td>\u2191116%<\/td>\n<\/tr>\n<tr>\n<td>3 \u5e74\u5b58\u6d3b\u7387<\/td>\n<td>18%<\/td>\n<td>62.70%<\/td>\n<td>\u2191244%<\/td>\n<\/tr>\n<tr>\n<td>\u56b4\u91cd\u526f\u4f5c\u7528\u7387<\/td>\n<td>58%<\/td>\n<td>19%<\/td>\n<td>\u219367%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\u8868\u683c\u5f37\u8abf\u4e86\u8a72\u7642\u6cd5\u7684\u6f5b\u529b\uff0c\u4f46\u60a3\u8005\u7fa4\u9ad4\u548c\u816b\u7624\u985e\u578b\u4e4b\u9593\u7684\u5dee\u7570\u503c\u5f97\u9032\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n<h2><strong>\u7d50\u8ad6<\/strong><\/h2>\n<p>\u56db\u7dad\u7121\u6bd2\u7642\u6cd5\u6574\u5408\u4e86\u89e3\u6c7a\u764c\u75c7\u8907\u96dc\u6027\u7684\u5c16\u7aef\u7b56\u7565\uff0c\u6bcf\u7a2e\u65b9\u6cd5\u90fd\u5f97\u5230\u65b0\u8208\u7814\u7a76\u7684\u652f\u6301\u3002\u7136\u800c\uff0c\u816b\u7624\u7570\u8cea\u6027\u3001\u81e8\u5e8a\u9a57\u8b49\u548c\u53ef\u8fd1\u6027\u7b49\u6311\u6230\u9700\u8981\u4e0d\u65b7\u63a2\u7d22\u3002\u5efa\u8b70\u7684\u53e3\u865f\u548c\u53e3\u865f\u65e8\u5728\u9ad4\u73fe\u8a72\u7642\u6cd5\u7684\u627f\u8afe\uff0c\u4e26\u5f15\u767c\u5c0d\u5176\u6539\u8b8a\u764c\u75c7\u6cbb\u7642\u6f5b\u529b\u7684\u9032\u4e00\u6b65\u8a0e\u8ad6\u3002<\/p>\n<h2>\u4e3b\u8981\u5f15\u6587<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a><\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a><\/li>\n<li><a href=\"https:\/\/www.lifespringcancer.com\/metronomic-chemotherapy\/\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a><\/li>\n<\/ul>\n<hr>\n<div class=\"ac-blog-cta\">\n<h2>\u9700\u8981\u5354\u52a9\u4e86\u89e3\u6cbb\u7642\u9078\u64c7\uff1f<\/h2>\n<p>\u6211\u5011\u7684\u60a3\u8005\u670d\u52d9\u5718\u968a\u53ef\u4ee5\u5e6b\u52a9\u60a8\u6e96\u5099\u5831\u544a\u4e26\u5b89\u6392\u9069\u7576\u7684\u5c08\u5bb6\u8aee\u8a62\u3002\u672c\u6587\u662f\u4e00\u822c\u8a0a\u606f\uff0c\u800c\u4e0d\u662f\u8a3a\u65b7\u3002<\/p>\n<p><a href=\"\/zh-hk\/appointment\/\">\u9810\u7d04\u8aee\u8a62<\/a> &nbsp;|&nbsp; <a href=\"\/zh-hk\/cancer\/\">\u63a2\u7d22\u6240\u6709\u764c\u75c7\u985e\u578b<\/a><\/p>\n<\/div>\n<p class=\"ac-blog-disclaimer\"><em>\u91ab\u7642\u514d\u8cac\u8072\u660e\uff1a\u672c\u6587\u50c5\u7528\u65bc\u4e00\u822c\u6559\u80b2\uff0c\u4e0d\u80fd\u53d6\u4ee3\u5408\u683c\u81e8\u5e8a\u91ab\u751f\u7684\u5efa\u8b70\u3002\u6cbb\u7642\u6c7a\u5b9a\u61c9\u57fa\u65bc\u500b\u4eba\u7684\u8a3a\u65b7\u3001\u5206\u671f\u3001\u75c5\u7406\u548c\u6574\u9ad4\u5065\u5eb7\u72c0\u6cc1\u3002\u5982\u679c\u60a8\u767c\u73fe\u6301\u7e8c\u6216\u4ee4\u4eba\u64d4\u6182\u7684\u75c7\u72c0\uff0c\u8acb\u5c0b\u6c42\u91ab\u7642\u8a55\u4f30\u3002<\/em><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Primary Peritoneal Cancer (Primary Peritoneal Carcinoma) is a rare malignancy originating from the peritoneum\u2014a thin lining that covers abdominal 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